Chronic UVB exposure enhances in vitro percutaneous penetration of 5‐aminulevulinic acid in hairless mouse skin

Akker, Johanna T. H. M.; Holroyd, J. Andrew; Vernon, David I.; Sterenborg, Henricus J. C. M.; Brown, Stanley B.

doi:10.1002/lsm.20004

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…In contrast to the previous finding that basal TEWL in photo-aged skin is similar to that in non-photoaged subjects aged 80-97 years [29] , the present studies demonstrate that daily sun exposure does induce dosedependent changes in basal TEWL, which is in agreement with previous findings [40] . The different results may be due to the subjects' ages.…”

Section: Discussioncontrasting

confidence: 57%

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Liu

Fluhr

Shu-min

et al. 2010

Skin Pharmacol Physiol

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Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18–50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

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Section: Discussioncontrasting

confidence: 57%

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Liu

Fluhr

Shu-min

et al. 2010

Skin Pharmacol Physiol

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“…In consistence with our previous work, MAL-induced PpIX fluorescence was higher in UV-exposed skin compared with non-UV-exposed skin (6). We consider this is most probably explained by increased MAL penetration in chronically UV-exposed skin due to altered stratum corneum barrier (7). However, epidermal hyperplasia may also contribute to enhanced PpIX formation, as it is well known that UV exposure induces epidermal hyperplasia (8).…”

Section: Funding Supportsupporting

confidence: 86%

Calcipotriol pretreatment enhances methyl aminolevulinate‐induced protoporphyrin IX: an in vivo study in hairless mice

Bay

Lerche

Togsverd‐Bo

et al. 2014

Photoderm Photoimm Photomed

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“…Van den Akker et al . () found that chronic UVB‐exposure induced changes in the mouse skin that resulted in a 10‐fold increase of percutaneous penetration for 5‐aminolevulinic acid compared with normal mouse skin. This increase is still less than through tape‐stripped skin.…”

Section: Ultraviolet Irradiationmentioning

confidence: 97%

“…However, tape stripping did not increase ALAHE‐induced PpIX fluorescence outside the application area (van den Akker et al ., ). In an in vitro study van den Akker also showed that penetration of ALA and the ALA esters was higher, 100‐ and 200‐fold respectively, through tape‐stripped rather than through normal mouse skin (van den Akker et al ., ).…”

Section: Mechnical Damage: Tape Stripping Abrasionmentioning

confidence: 99%

Percutaneous absorption in diseased skin: an overview

Chiang¹,

Tudela²,

Maibach³

2012

J of Applied Toxicology

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The stratum corneum's (SC) functions include protection from external hazardous environments, prevention of water loss and regulation of body temperature. While intact skin absorption studies are abundant, studies on compromised skin permeability are less common, although products are often used to treat affected skin. We reviewed literature on percutaneous absorption through abnormal skin models. Tape stripping is used to disrupt water barrier function. Studies demonstrated that physicochemical properties influence the stripping effect: water-soluble drugs are more affected. Abrasion did not affect absorption as much. Freezing is commonly used to preserve skin. It does not seem to modify water absorption, but still increases the penetration of compounds. Comparatively, heating the skin consistently increased percutaneous absorption. Removing SC lipids may increase percutaneous absorption of drugs. Many organic solvents are employed to delipidize. Delipidization with chloroform-methanol increased hydrophilic compound permeability, but not lipophilic. Acetone pre-treatment enhanced hydrophilic compound penetration. More data is needed to determine influence on highly lipophilic compound penetration. Sodium lauryl sulfate (SLS) induces irritant dermatitis and is frequently used as a model. Studies revealed that SLS increases hydrophilic compound absorption, but not lipophilic. However, skin irritation with other chemicals increases lipophilic penetration as much as hydrophilic. Animal studies show that UV exposure increases percutaneous absorption whereas human studies do not. Human studies show increased penetration in psoriatic and atopic dermatitis skin. The data summarized here begin to characterize flux alteration associated with damaged skin. Understanding the degree of alteration requires interpretation of involved conditions and the enlarging of our database to a more complete physicochemical spectrum.

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Chronic UVB exposure enhances in vitro percutaneous penetration of 5‐aminulevulinic acid in hairless mouse skin

Cited by 14 publications

References 27 publications

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Calcipotriol pretreatment enhances methyl aminolevulinate‐induced protoporphyrin IX: an in vivo study in hairless mice

Percutaneous absorption in diseased skin: an overview

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