Chronic Venous Disease

Bergan, John J.; Schmid‐Schönbein, Geert W.; Smith, Philip; Nicolaides, Andrew; Boisseau, M. R.; Eklöf, Bo

doi:10.1056/nejmra055289

Cited by 837 publications

(725 citation statements)

References 86 publications

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“…Signs such as varicose veins, edema, trophic skin changes and ulcers and symptoms such as pain, cramps, itching, heavy legs, burning and throbbing are often associated with limitations in activities of daily living and functional performance, along with psychological changes and changes to the perception of the health condition 5,[7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

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Correlação entre classificação clínica ceap e qualidade de vida na doença venosa crônica

Moura¹,

Gonçalves²,

Navarro³

et al. 2010

Rev. bras. fisioter.

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Objectives: To evaluate the quality of life (QOL) of patients with chronic venous disease (CVD) and to analyze the relationship between QOL and disease severity. Methods: This was a cross-sectional study with a convenience sample of 50 participants with a diagnosis of CVD. The participants were classified according to disease severity using the CEAP clinical classification (Clinical manifestations, Etiological factors, Anatomical distribution of disease, Pathophysiological findings). They were then divided into two groups: CEAP 1, 2 and 3 (less clinically compromised) and CEAP 4, 5 and 6 (more clinically compromised). QOL was evaluated using the SF-36 questionnaire. The Mann-Whitney U test was used to compare the SF-36 scores between the groups. The Spearman correlation was used to evaluate the association between QOL and the CEAP. Differences were considered statistically significant with p < 0.05. The SPSS statistical software version 16.0 was used for the analyses. Results: Seventy-four percent of the sample was female. The mean age was significantly higher (p<0.001) among participants classified as CEAP 4, 5 and 6 (56.6±10.3) than among those classified as Key words: quality of life; venous insufficiency; physical therapy. ResumoObjetivos: Avaliar a qualidade de vida (QV) na doença venosa crônica (DVC) e analisar a relação entre QV e severidade da doença. Resultados: 74% da amostra eram mulheres e a média de idade foi significativamente maior (p<0,001) entre os indivíduos CEAP 4, 5, 6 (56,6±10,3) do que entre os CEAP 1, 2, 3 (40,6±10,7). Todos os domínios do Componente Saúde Física (CSF) do SF-36 apresentaram escores significativamente menores no grupo CEAP 4, 5, 6 (p<0,05), representando maior comprometimento físico e funcional. Apenas os domínios do CSF apresentaram correlação negativa e estatisticamente significativa com a CEAP. Conclusões: Os aspectos físicos e funcionais foram mais comprometidos, sobretudo nas formas mais graves da DVC. Estes achados podem contribuir para melhor compreensão dos efeitos da DVC na QV e melhor direcionamento das intervenções terapêuticas nessa população.Palavras-chave: qualidade de vida; insuficiência venosa; fisioterapia.

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Section: Introductionmentioning

confidence: 99%

“…Depression and social isolation have also been reported as manifestations due to CVD, especially in more advanced stage of the disease, characterized by the presence of unhealed varicose ulcers 7,18 .…”

Section: Introductionmentioning

confidence: 99%

Correlação entre classificação clínica ceap e qualidade de vida na doença venosa crônica

Moura¹,

Gonçalves²,

Navarro³

et al. 2010

Rev. bras. fisioter.

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“…Significant obstacles to the main venous outflow collectors, with overload of collaterals and associated refluxes, have been described at the level of the iliac veins in obstructive CVD, and also in the inferior vena cava in primary Budd-Chiari syndrome (Bergan et al, 2006;Raju et al, 2006;Lee et al, 2006). Figure 3 Physiology of cerebral venous return.…”

Section: Role Of Venous Collateral Circulation and The Concept Of Vicmentioning

confidence: 99%

“…Conversely, where there occurs a disturbance or, especially, a reversal of flow direction, one or both factors may promote an inflammatory reaction, and particularly the expression of surface adhesion molecules (Bergan et al, 2006;Sorescu et al, 2004). Therefore, the oscillatory flow assessed in the cerebral venous system can be considered a proinflammatory stimulus, potentially contributing to MS multifactorial etiopathogenesis (Zamboni et al, 2007).…”

Section: Peculiarity Of Anomalous Cerebral Venous Blood Flow In Multimentioning

confidence: 99%

Anomalous Venous Blood Flow and Iron Deposition in Multiple Sclerosis

Singh

Zamboni

2009

J Cereb Blood Flow Metab

180

155

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Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.

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“…C hronic venous disease (CVD) is a common disorder with a significant impact on quality of life and health care costs in western countries (1,2). Occurrence of symptoms, which are variously described as pain, heaviness, tension, ache and cramp, and itching, tingling or swelling sensations, is high, occurring in close to 95% of CVD-affected patients (3).…”

mentioning

confidence: 99%