Cica-care gel sheeting in the management of hypertrophic scarring

Carney, Shirley A.; Cason, C.G.; Gowar, John P; Stevenson, J.H.; McNee, Janice; Groves, A.R.; Thomas, Steven; Hart, Nicholas; Auclair, Paul L.

doi:10.1016/s0305-4179(06)80016-1

Cited by 113 publications

(61 citation statements)

References 10 publications

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“…Since these early studies, 1,30,31 the subject of scar therapy has advanced dramatically along with clinical evidence, commercial engagement, and consumer interest. [32][33][34][35][36] This progression has been driven by the ongoing clinical support which continues to raise interest and awareness of the efficacy of SGS in scar management in comparison to the alternatives. 32,37,38 In fact, it is proposed that topical SGS and intralesional steroids are the only evidence-based recommendable forms of treatment to control the quality of a scar.…”

Section: Advantages Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

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Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring. SCOPE AND SIGNIFICANCESilicone gel sheeting (SGS) has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed. As such, topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. This article aims to review a breadth of literature to gain an insight not only into how, but also why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance as a comparison. TRANSLATIONAL RELEVANCESilicone has been used for more than 30 years in the treatment of cutaneous scars.1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.

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Section: Advantages Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

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“…The experimental data obtained also showed the need for continuous contact between the dressing and skin to cause prolonged hydration of the stratum corneum. One would expect, as has been reported [17], patient compliance to be essential for effective treatment. The novel infrared ATR method for penetration depth analysis is applicable to other analytes and substrates which have well-separated characteristic absorption bands.…”

Section: Discussionmentioning

confidence: 89%

Use of Infrared Attenuated Total Reflectance Spectroscopy for the in vivo Measurement of Hydration Level and Silicone Distribution in the Stratum corneum following Skin Coverage by Polymeric Dressings

Branagan

Chenery

Nicholson³

2000

Skin Pharmacol Physiol

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The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing.

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“…47,48 Silicone-based treatments have been shown to improve the volume, elasticity, color, and firmness in hypertrophic scars and keloids. 4,5,[48][49][50] When used prophylactically on surgical incisions, it can prevent the development of pathologic scars. [51][52][53] Silicone gel sheets were the mainstay of siliconebased treatments until relatively recently.…”

Section: Mechanical Therapymentioning

confidence: 99%

Emerging Therapies for Scar Prevention

Block

Gosain

2015

Advances in Wound Care

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Significance: There are *12 million traumatic lacerations treated in the United States emergency rooms each year, 250 million surgical incisions created worldwide every year, and 11 million burns severe enough to warrant medical treatment worldwide. In the United States, over $20 billion dollars per year are spent on the treatment and management of scars. Recent Advances: Investigations into the management of scar therapies over the last decade have advanced our understanding related to the care of cutaneous scars. Scar treatment methods are presented including topical, intralesional, and mechanical therapies in addition to cryotherapy, radiotherapy, and laser therapy. Critical Issues: Current treatment options for scars have significant limitations. This review presents the current and emerging therapies available for scar management and the scientific evidence for scar management is discussed. Future Directions: Based upon our new understanding of scar formation, innovative scar therapies are being developed. Additional research on the basic science of scar formation will lead to additional advances and novel therapies for the treatment of cutaneous scars.

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Cica-care gel sheeting in the management of hypertrophic scarring

Cited by 113 publications

References 10 publications

The Use of Silicone Adhesives for Scar Reduction

The Use of Silicone Adhesives for Scar Reduction

Use of Infrared Attenuated Total Reflectance Spectroscopy for the in vivo Measurement of Hydration Level and Silicone Distribution in the Stratum corneum following Skin Coverage by Polymeric Dressings

Emerging Therapies for Scar Prevention

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