Ciclosporin A Cationic Emulsion 0.1% for the Management of Dry Eye Disease: Facts That Matter for Eye-Care Providers

Labétoulle, Marc; Leonardi, Andrea; Pisella, Pierre‐Jean; Baudouin, Christophe

doi:10.1080/09273948.2022.2088566

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…[ 108 ] More recently, a newer formulation of Cyclosporin A Cationic Emulsion 0.1% has shown promising results in moderate to severe dry eye patients with improvement in clinical signs evident as early as 4 weeks, though, up to 12 months of treatment is recommended for more sustained effects. [ 109 ] Further studies are required to assess its efficacy in postrefractive surgery dry eye patients.…”

Section: Managementmentioning

confidence: 99%

Refractive surgery and dry eye - An update

Nair

Kaur

Sharma

et al. 2023

Indian Journal of Ophthalmology

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Dry eye disease is the most common complication and a frequent cause of patient dissatisfaction after corneal laser refractive surgery, which includes laser-assisted in situ keratomileusis (LASIK), small-incision lenticule extraction (SMILE), and photorefractive keratectomy (PRK). It has a complex, multifactorial etiology and is characterized by a highly variable clinical presentation. A detailed preoperative screening and optimization of the ocular surface prior to refractive surgery are the key to minimizing the incidence and severity of postoperative dry eye. Diagnosis of postrefractive surgery dry eye remains a challenge as no single symptom or clinical parameter is confirmative of the condition, and the symptoms and signs may not correlate well in many cases. A thorough understanding of the pathomechanism of the disease and its manifestations is essential to facilitate a treatment approach that is individualized for each patient. This article reviews various aspects of postrefractive surgery dry eye including its epidemiology, etiopathogenesis, risk factors, diagnosis, and management.

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Section: Managementmentioning

confidence: 99%

Refractive surgery and dry eye - An update

Nair

Kaur

Sharma

et al. 2023

Indian Journal of Ophthalmology

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The place of ciclosporin A cationic emulsion 0.1% in the therapy of xerophthalmia

Maychuk,

Yani,

Brzheskiy

et al. 2024

Rus. Ann. Ophthal.

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Basics of Diagnosis and Treatment of Dry Eye Syndrome During Refractive Surgery

Trubilin,

Polunina,

Trubilin

et al. 2024

Oftalʹmologiâ

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Given the prevalence of refractive surgery in modern ophthalmological practice, when preparing a patient for this type of surgery, it is important to understand the multifactorial mechanism of the development of dry eye syndrome in this group of patients. Analysis of the literature data made it possible to identify key factors in the disruption of the tear formation process after refractive surgery, which include the intersection of the nerve endings of the cornea, which in turn reduces the frequency of blinking and the distribution of the tear film over the ocular surface, and also causes a violation regarding neurotrophic factors secreted by the nerve endings of the cornea . The presence of a postoperative inflammatory reaction, which has a specific course, manifested in a change in the biochemical properties of the tear, damage to the goblet cells of the conjunctiva during the creation of a vacuum during LASIK and SMILE, leading to a subsequent deficiency of mucin in the tear, changes in the curvature of the cornea caused by laser refractive surgery are factors influencing the development of dry eye syndrome after refractive surgery. When preparing a patient for refractive surgery, to reduce the risk of developing severe forms of dry eye syndrome, including corneal ulceration, it is necessary to take into account a history of systemic diseases and allergic reactions, especially in patients with high myopia. The influence of cosmetic procedures, such as eyelash extensions, eyelid tattooing, blepharoplasty, and the use of botulinum toxin in the periorbital area on the course of the postoperative period during refractive surgery, has been poorly studied. Research in this area opens up a new range of opportunities to reduce the incidence of dry eye syndrome in patients after refractive surgery and improve the quality of life of patients and patient satisfaction with the surgical intervention.

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Ciclosporin A Cationic Emulsion 0.1% for the Management of Dry Eye Disease: Facts That Matter for Eye-Care Providers

Cited by 3 publications

References 32 publications

Refractive surgery and dry eye - An update

Refractive surgery and dry eye - An update

The place of ciclosporin A cationic emulsion 0.1% in the therapy of xerophthalmia

Basics of Diagnosis and Treatment of Dry Eye Syndrome During Refractive Surgery

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