CIDP and hemopathies, an underestimated association

Deschamps, Nathalie; Mathis, Stéphane; Duchesne, Mathilde; Ghorab, Karima; Gallouedec, Gaël; Richard, Laurence; Boulesteix, Jean-Marc; Corcia, Philippe; Magy, Laurent; Vallat, Jean‐Michel

doi:10.1016/j.jns.2021.118055

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…CIDP is a neurological paraneoplastic syndrome that often occurs in the context of haematological malignancies, such as Hodgkin’s and non-Hodgkin’s lymphomas, chronic myelomonocytic leukaemia, Waldenström’s macroglobulinaemia, multiple myeloma and hairy cell leukaemia 7 8. CIDP is also described in association with breast cancers, lung cancers, intra-abdominal tumours, melanomas and some gynaecological cancers 9…”

Section: Discussionmentioning

confidence: 99%

Chronic inflammatory demyelinating polyneuropathy caused by hepatocellular carcinoma

et al. 2023

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Paraneoplastic syndromes are rare abnormal endocrine or immune responses triggered by neoplasms. Chronic inflammatory demyelinating polyneuropathy (CIDP) is one such example. CIDP is an acquired, immune-mediated neuropathy affecting the peripheral nerves and nerve roots. It is associated with many types of cancers, especially haematological malignancies. We report the case of a man in his 60s who presented to the emergency department with acute symptoms of upper and lower extremity paresis and decreased sensation in the toes and tips of his fingers. Laboratory tests were normal. Electrodiagnostic studies showed diffuse motor and sensory dysfunction in all extremities; a diagnosis of CIDP was consequently made. Imaging studies showed a large left lobe liver mass. Subsequent biopsy revealed histopathological findings characteristic of hepatocellular carcinoma. After failure of medical treatment with intravenous immunoglobulin and corticosteroids, laparoscopic resection of the tumour was planned, performed and resulted in complete resolution of symptoms. At 18 months postoperatively, the patient was asymptomatic.

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Section: Discussionmentioning

confidence: 99%

Chronic inflammatory demyelinating polyneuropathy caused by hepatocellular carcinoma

et al. 2023

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Neuropatie periferiche

et al. 2023

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Case Report: Application of 18F-FDG PET/CT in identifying plasmacytoma in monoclonal gammopathy associated peripheral neuropathy

Weng,

Lin,

Sun

2024

Front. Nucl. Med.

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Peripheral neuropathy is a prevalent complication in plasma cell disorders, posing significant diagnostic and therapeutic challenges. This study presents three cases initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Despite initial symptom regression post-immunomodulatory treatment, the patients exhibited progressive neurological deficits. Advanced laboratory evaluation confirmed monoclonal protein presence, yet traditional diagnostic methods, including bone marrow biopsy and flow cytometry, yielded normal results. Utilizing 18F-FDG PET/CT, we identified multiple hypermetabolic vertebral lesions, which upon biopsy, confirmed the diagnosis of plasmacytoma. Our findings underscore the utility of PET/CT as a reliable diagnostic tool for monoclonal gammopathy associated neuropathy, advocating for its consideration in cases with equivocal diagnosis. When the diagnosis is in doubt, biopsy of a lesion may facilitate early and accurate diagnosis, potentially influencing treatment strategies and patient outcomes.

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CIDP and hemopathies, an underestimated association

Cited by 3 publications

References 30 publications

Chronic inflammatory demyelinating polyneuropathy caused by hepatocellular carcinoma

Chronic inflammatory demyelinating polyneuropathy caused by hepatocellular carcinoma

Neuropatie periferiche

Case Report: Application of 18F-FDG PET/CT in identifying plasmacytoma in monoclonal gammopathy associated peripheral neuropathy

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