Cigarette Smoking and Erectile Dysfunction: Focus on NO Bioavailability and ROS Generation

Tostes, Rita C.; Carneiro, Fernando S.; Lee, Anthony J.; Giachini, Fernanda R.; Leite, Rômulo; Osawa, Yoichi; Webb, R. Clinton

doi:10.1111/j.1743-6109.2008.00804.x

Cited by 103 publications

(87 citation statements)

References 108 publications

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“…Ultimately, the NO causes a locally mediated increase in levels of the second messenger cGMP which further enhance the smooth muscle induced vasodilation. [11] If this NOS-NO-cGMP chain reaction cannot occur, it is defined as erectile dysfunction (ED), which is the inability to attain and/or maintain a satisfactory erection for sexual intercourse. Male sexual arousal is a complex process that involves the brain, hormones, nerves, muscles, psychological factors, the environment and blood vessels.…”

Section: Introductionmentioning

confidence: 99%

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The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk. We also summarize research indicating that VD associates with reduced risk of several nonvascular contributing factors for ED. Available literature demonstrates relatively high rates of low VD serum levels in ED patients. Based on the preclinical and clinical data available in the literature, to date, we infer that VD play a critical role in maintaining erectile function in humans. Nevertheless, this should also be tested through randomized controlled studies on the effect of VD supplementation with larger population.

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Section: Introductionmentioning

confidence: 99%

“…[11] Moreover, ED can be viewed as an early marker of coronary endothelial dysfunction and atherosclerosis. [12,13] Risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle are commonly seen in ED ( Figure 2) and ASCV diseases.…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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“…Prevention against smoking represents an important approach to reduce the risk of erectile dysfunction. 48 The Massachusetts Male Aging Study found that smokers are more prone to erectile dysfunction than non-smokers. 45 Another study showed that duration of smoking and the number of cigarettes smoked per day are directly correlated with erectile dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

et al. 2011

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The aim of this study is to evaluate the association between physical activity level and physical fitness with erectile dysfunction in men aged 40-75 years. We examined 180 men aged 40-75 years. The individuals were evaluated for age, presence of dyslipidemia and smoking and for anthropometric parameters for the characterization of body mass index. For assessing the level of physical fitness, a test was performed to measure the indirect maximum oxygen consumption. The evaluation of erectile function was made by the International Index of Erectile Function questionnaire and assessment of physical activity level by the International Physical Activity questionnaire in its short version. This study showed that younger men with higher physical activity and better physical fitness are less likely to suffer from erectile dysfunction. Multivariable analysis through logistic regression showed that age (odds ratio (OD) ¼ 1.15; 95% confidence interval (95% CI) ¼ 1.07-1.23), physical activity (OD ¼ 10.38; 95% CI ¼ 3.94-27.39) and physical fitness (OD ¼ 4.62; 95% CI ¼ 1.75-12.25) were independent variables associated with erectile dysfunction. This study reinforces the concept that healthy habits have a direct effect on erectile function.

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“…La DE es considerada un problema de salud pública mayor, que afecta seriamente la calidad de vida de los pacientes 29 , suele estar relacionada a importantes co-morbilidades como ECV, DM e HTA, que actúan, en ocasiones, exacerbándola. Basados en los hallazgos presentados en esta investigación y la literatura consultada puede concluirse que, tal como en otras poblaciones masculinas, la DE es un problema común entre hombres Latinoamericanos, con una prevalencia moderada que aumenta significativamente con la edad, y que es bastante alta en pacientes con antecedentes de ECV e indicación de rehabilitación cardíaca.…”

Section: Conclusiónunclassified