Cigarette smoking and glaucoma in the United States population

Law, Samuel M.; Lu, Xuyang; Yu, Fei; Tseng, Victoria L.; Law, Simon K.; Coleman, Anne L.

doi:10.1038/eye.2017.292

Cited by 50 publications

(45 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study by Jung et al found that glaucomatous patients with multiple retinal nerve fiber layer (RNFL) defects had a higher prevalence of concomitant vascular diseases (including HTN, end-stage renal disease or cerebrovascular disease) compared to those with glaucoma and no RNFL defects [59]. Additionally, HTN was found to be a risk factor for reduced RNFL in healthy individuals in the European Eye Epidemiology study [60]. These results highlight the potential role of vascular…”

Section: Systemic Hypertension and Hypotensionmentioning

confidence: 96%

“…The analyzed studies did not determine smoking as a risk factor for POAG incidence [46] or progression [43]. However, heavy smoking, which was defined by a greater number of cigarette packs smoked daily was associated with higher odds of glaucoma [60]. With this, the role of cytochrome CYP1B1 was confirmed in primary congenital glaucoma, as it influenced the development of the trabecular meshwork [61,62]; CYP1B1 is also a potential regulator in energy homeostasis that promotes hypertension as well [63].…”

Section: Systemic Hypertension and Hypotensionmentioning

confidence: 99%

See 1 more Smart Citation

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Grzybowski¹,

Och

Kanclerz

et al. 2020

JCM

View full text Add to dashboard Cite

Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of primary open angle glaucoma (POAG) is unclear and multiple ocular risk factors have been proposed, including intraocular pressure, ocular perfusion pressure, ocular blood flow, myopia, central corneal thickness, and optic disc hemorrhages. The purpose of this review was to analyze the association between systemic vascular risk factors (including hypertension, diabetes, age, and migraine) and POAG, based on major epidemiological studies. Reports presenting the association between POAG and systemic vascular risk factors included a total of over 50,000 patients. Several epidemiological studies confirmed the importance of vascular risk factors, particularly hypertension and blood pressure dipping, in the pathogenesis and progression of glaucomatous optic neuropathy. We found that diabetes mellitus is associated with elevated intraocular pressure, but has no clear association with POAG. No significant correlation between migraine and POAG was found, however, the definition of migraine varied between studies.

show abstract

Section: Systemic Hypertension and Hypotensionmentioning

confidence: 96%

Section: Systemic Hypertension and Hypotensionmentioning

confidence: 99%

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Grzybowski¹,

Och

Kanclerz

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Although following our methodology identified associations between smoking and the development of a variety of diseases, it found that smoking was protective against glaucoma and cataracts. These findings are surprising, though at least one study has reported similar results regarding glaucoma and the potential protective effect of nicotine [28]. Determining a patient's smoking status (past, present, none) accurately is challenging.…”

Section: Discussionmentioning

confidence: 99%

“…Another use of following an unbiased prediction modeling approach is to identify benefits in behavior that is well known to be harmful, such as tobacco use. For example, smoking could be identified as associated with the development of a variety of diseases but protective against others; at least one study reported on the potential protective effect of nicotine against glaucoma [28].…”

Section: Introductionmentioning

confidence: 99%

Unbiased prediction modeling for discovery research in nonalcoholic fatty liver disease

Kartoun¹,

Aggarwal²,

Perer³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent yet underdiagnosed and under-discussed disease. Given that NAFLD has not been explored sufficiently compared with other diseases, opportunities abound for scientists to discover new biomarkers (such as laboratory observations, current comorbidities, and behavioral descriptors) that can be linked to the development of conditions and complications that may develop at a later stage of the patient’s life.Methods: We analyzed IBM Explorys, a repository that contains electronic medical records (EMRs) of more than 60 million individuals. We used a classification algorithm that members of our group have previously validated to identify patients at a high probability for NAFLD. The algorithm identified more than 80,000 patients with a high probability for NAFLD who had at least 5 years of follow-up. We followed an unbiased approach for prediction modeling and applied standard statistical methods (such as logistic regression and bootstrapping) as well as Clinical Classifications Software (CCS) definitions to identify associations between a variety of covariates and disease outcomes.Results: Our methodology identified several thousand strongly statistically significant associations between covariates and outcomes in NAFLD. Most of the associations are known, but others may be new and require further investigation in subsequent studies.Conclusions: A discovery mechanism composed of standard statistical methods and applied on a large collection of EMRs confirmed known associations and identified potentially new associations that can act as biomarkers that might merit further research.

show abstract

“…Another use of a discovery engine is its ability to identify benefits in behavior that are well known as harmful, such as tobacco use. For example, smoking could be identified as associated with the development of a variety of diseases, but protective against others; at least one study reported on the potential protective effect of nicotine within the context of glaucoma [28].…”

mentioning

confidence: 99%

Electronic Medical Records for Discovery Research in Nonalcoholic Fatty Liver Disease

Kartoun¹,

Aggarwal

Perer³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent yet under-diagnosed and under-discussed disease. Given that NAFLD has not been explored sufficiently compared with other diseases, opportunities abound for scientists to discover new biomarkers (such as laboratory observations, current comorbidities, behavioral descriptors) that can be linked to the development of conditions and complications that may develop at a later stage of the patient’s life. Methods: We analyzed IBM Explorys, a repository that contains electronic medical records (EMRs) of more than 50 million individuals. We used a classification algorithm that members of our group have previously validated to identify patients at a high probability for NAFLD. The algorithm identified more than 80,000 patients with a high probability for NAFLD who had at least 5 years of follow-up. We applied standard statistical methods (such as logistic regression and bootstrapping) and used Clinical Classifications Software (CCS) definitions to identify associations between a variety of covariates and disease outcomes. Results: Our methodology identified several thousand strongly statistically significant associations between covariates and outcomes in NAFLD. Most of the associations are known, but others may be new and require further investigation in subsequent studies. Conclusions: A discovery mechanism composed of standard statistical methods applied on a large collection of EMRs, confirmed known associations and identified potentially new associations that can act as biomarkers that might merit further research.

show abstract

Cigarette smoking and glaucoma in the United States population

Cited by 50 publications

References 47 publications

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019

Unbiased prediction modeling for discovery research in nonalcoholic fatty liver disease

Electronic Medical Records for Discovery Research in Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About