2006
DOI: 10.3390/md403082
|View full text |Cite
|
Sign up to set email alerts
|

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Abstract: Abstract:Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by neurological, cardiovascular and gastrointestinal disorders. The pharmacology of ciguatoxins is characterised by their ability to cause persistent activation of voltage-gated sodium channels, to increase neuronal excitability and neurotransmitter rele… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
114
0

Year Published

2008
2008
2017
2017

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 119 publications
(115 citation statements)
references
References 167 publications
(273 reference statements)
1
114
0
Order By: Relevance
“…Therefore, the development of a specific antidote has been severely hampered by the lack of information and it is only by supportive symptomatic treatment that ciguatera is currently treated. Today, at least 15 articles describe the effect of ciguatoxins on voltage-gated sodium and potassium channels Nicholson, 2006). For gambierol, there is some dispute about its ability to activate VGSCs.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the development of a specific antidote has been severely hampered by the lack of information and it is only by supportive symptomatic treatment that ciguatera is currently treated. Today, at least 15 articles describe the effect of ciguatoxins on voltage-gated sodium and potassium channels Nicholson, 2006). For gambierol, there is some dispute about its ability to activate VGSCs.…”
Section: Introductionmentioning
confidence: 99%
“…Consumption of contaminated fish causes ciguatera fish poisoning characterized by gastrointestinal and neurological symptoms and by hypotension, bradycardia, respiratory difficulties, and paralysis in severe cases (1).…”
mentioning
confidence: 99%
“…In general, CTXs are potent toxins of voltage-gated sodium channels (VGSCs), with affinities in the nanomolar range (1,2). Their mechanism of action includes (i) a hyperpolarizing shift in the voltage dependence of channel activation causing channel opening at resting membrane potentials and (ii) disruption of the inactivation resulting in persistent activation (3).…”
mentioning
confidence: 99%
“…Ciguatoxin poisoning is the most frequent food-borne illness related to fin-fish consumption although it is rarely fatal. Symptoms include neurological, cardiovascular, and gastrointestinal disorders, and ciguatoxins can be detected in all body fluids (12). Most people recover slowly over time, which can take from weeks to years.…”
Section: Marine Polyethersmentioning
confidence: 99%