Cilia impairment in bronchial epithelial cells detected in autopsy material of SARS-CoV-2-infected patient

Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

“…Multiple desquamated bronchial epithelial cells were visible in the bronchial lumens in autopsies of COVID-19 patients. Ciliary impairment is accompanied by the axoneme loss and basal body misorientation ( Potashnikova et al., 2023 ). SARS-CoV-2 replication leads to a rapid loss of the ciliary layer and impairs mucociliary clearance in a reconstructed human bronchial epithelium model ( Robinot et al., 2021 ).…”