Cimetidine in Bleeding Peptic Ulcer

Hoare, A M; Bradby, G V; Hawkins, Clifford F.; Kang, Jin-Kyung; Dykes, P. W.

doi:10.1016/s0140-6736(79)92069-5

Cited by 61 publications

(12 citation statements)

References 7 publications

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“…Of all patients in the trial, 11 of 51 on cimetidine rebled compared to 12 of 50 on placebo; cimetidine was of no benefit in the elderly, in severe bleeding, or in the 70 patients who had a peptic ulcer identified at endoscopy. Similarly Hoare, Bradby and Hawkins (1979) reported a trial of 66 patients admitted with bleeding peptic ulceration; results on the first 40 patients in this trial had been previously published (Dykes and Hoare, 1977). Of patients with DU, only 2 of 14 treated with cimetidine rebled compared to 10 of 19 on placebo, the majority of these patients were over 65 years old and cimetidine significantly reduced rebleeding in the elderly group (P<0 05).…”

Section: Discussionmentioning

confidence: 90%

Cimetidine therapy does not prevent rebleeding from peptic ulceration

Carr‐Locke

Taverner

Wicks

1984

Postgraduate Medical Journal

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Summary One-hundred and five patients admitted to hospital with symptoms of acute upper gastrointestinal haemorrhage shown at endoscopy to be due to peptic ulceration were entered into a prospective double-blind controlled trial of cimetidine versus placebo therapy. The trial therapy was commenced within 12 hr of admission and continued for 7 days. Cimetidine therapy made no difference to the transfusion requirements, rebleeding rate or number of operations performed in patients with either gastric or duodenal ulcers, nor was it of benefit in patients aged over 65 years of age.

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Section: Discussionmentioning

confidence: 90%

Cimetidine therapy does not prevent rebleeding from peptic ulceration

Carr‐Locke

Taverner

Wicks

1984

Postgraduate Medical Journal

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“…The straightness of the line obtained after plotting served as a control of the experimental conditions, any change in its slope indicating an altered perfusion during the recording. Total gastric blood flow was calculated from the linear plot of the A-elimination curves, using the equation proposed by Zierler14 as modified by Bassingthwaighte.15 16 (2) where Cp = peak value of recorded radioactivity; CT = radioactivity at time T.…”

Section: Statisticsmentioning

confidence: 99%

Effect of cimetidine on augmented gastric blood flow in duodenal ulcer patients.

Ivarsson¹,

Darle²,

Lundgren³

1984

Gut

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SUMMARY Blood flow in the human stomach was measured during operation with a 85Krypton washout method which made simultaneous determinations of total blood flow and intramural flow distribution possible. The antrum and the corpus of the stomach could be investigated separately. Eleven patients with duodenal ulcer disease were studied during pentagastrin infusion and after the addition of cimetidine, 3 mg/kg bw, to evaluate the effect of the drug on augmented gastric blood flow. Received for publication 5 December 1983 used, is that this method only reflects blood flow to the secreting part of the gastric mucosa, possibly only to the parietal cell mass, while the majority of peptic ulcer bleedings originate elsewhere in the stomach or duodenum.Using an inert gas washout method, which provides information on total gastric blood flow as well as on its intramural distribution, we have earlier studied in a quantitative manner the gastric blood flow in norrhal subjects and duodenal ulcer patients.These studies showed that duodenal ulcer patients exhibited a different pattern of gastric blood flow from normal subjects, both in size and distribution.8 9 In the present study we investigated the effect of cimetidine on blood flow in the actively secreting human stomach. These studies were performed intraoperatively in duodenal ulcer patients. A few studies were also carried out in a series of experiments on the cat and these are also reported below.Methods

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“…The discovery of the H2 blockers, the introduction of the first one without major side effects-cimetidine-and the successful early trials in the production of healing of both gastric and duodenal ulcers led to early optimism that cimetidine and subsequent H2 blockers would be valuable agents in patients with intestinal 763 A. E. Read bleeding. In the event they have proved disappointing in patients with bleeding chronic ulcers (Siddio et al, 1979;La Brooy et al, 1979), though at least one group have found some advantage in the patient with bleeding gastric ulcer (Hoare et al, 1979). Although they are given to the patient who bleeds from a chronic ulcer, they are given to heal the ulcer and not to stop the bleeding.…”

Section: New Causes Of Intestinal Bleeding?mentioning

confidence: 99%

Gastrointestinal bleeding

Read¹

1984

Postgraduate Medical Journal

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Cimetidine in Bleeding Peptic Ulcer

Cited by 61 publications

References 7 publications

Cimetidine therapy does not prevent rebleeding from peptic ulceration

Cimetidine therapy does not prevent rebleeding from peptic ulceration

Effect of cimetidine on augmented gastric blood flow in duodenal ulcer patients.

Gastrointestinal bleeding

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