CineECG: A novel method to image the average activation sequence in the heart from the 12-lead ECG

Boonstra, Machteld; Brooks, Dana H.; Loh, Peter; Dam, Peter M. van

doi:10.1016/j.compbiomed.2021.105128

Cited by 8 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 10 The electrical activation pathways are derived from the vectorcardiogram and applied to a standard model of the cardiac anatomy. 11 CineECG is thus able to relate clinical notable components of cardiac activation to the cardiac anatomy 12 and is rather robust to electrode misplacement. 12 CineECG has previously found increased electrical activity in the right ventricular outflow tract, during the end of the QRS complex, in spontaneous and ajmaline-induced Brugada Syndrome patients 11 and accurately differentiate between normal depolarization and bundle branch blocks.…”

Section: Introductionmentioning

confidence: 99%

“… 11 CineECG is thus able to relate clinical notable components of cardiac activation to the cardiac anatomy 12 and is rather robust to electrode misplacement. 12 CineECG has previously found increased electrical activity in the right ventricular outflow tract, during the end of the QRS complex, in spontaneous and ajmaline-induced Brugada Syndrome patients 11 and accurately differentiate between normal depolarization and bundle branch blocks. 9 An important benefit of the CineECG modality is the easy application and reliance on the standard 12-lead ECG.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CineECG analysis provides new insights into Familial ST-segment Depression Syndrome

et al. 2023

View full text Add to dashboard Cite

Aims Familial ST-segment Depression Syndrome (Fam-STD) is a novel inherited cardiac disease associated with arrhythmias and sudden cardiac death. This study aimed at investigating the cardiac activation pathway in patients with Fam-STD, modelling the electrocardiogram (ECG) phenotype, and performing in-depth ST-segment analyses. Methods and results CineECG analysis of patients with Fam-STD and age- and sex-matched controls. The groups were compared using the CineECG software which included the trans-cardiac ratio and the electrical activation pathway. We simulated the Fam-STD ECG phenotype by adjusting action potential duration (APD) and action potential amplitude (APA) in specific cardiac regions. High-resolution ST-segment analyses were performed per lead by dividing the ST-segment into nine 10 ms subintervals. Twenty-seven Fam-STD patients (74% females, mean age 51.6 ± 6.2 years) and 83 matched controls were included. Among Fam-STD patients, electrical activation pathway analysis in the anterior-basal orientation showed significantly abnormal direction toward the basal areas of the heart starting from QRS 60–89 ms until Tpeak-Tend (all P < 0.001). Simulations with shortened APD and reduced APA in the left ventricle basal regions recapitulated the Fam-STD ECG phenotype. Detailed ST-segment analyses showed significant differences in all nine 10 ms subintervals (all P < 0.01), with the most prominent findings during the 70–79/80–89 ms intervals. Conclusion CineECG analyses indicated abnormal repolarization with basal directions, and the Fam-STD ECG phenotype was simulated by reducing APD and APA in the left ventricle basal regions. Detailed ST-analysis showed amplitudes consistent with the proposed diagnostic criteria for Fam-STD patients. Our findings provide new insight into the electrophysiological abnormalities of Fam-STD.

show abstract