Cinnabarinic acid as a potential prognostic marker of schizophrenia

Shilov, Yu E; Baymeeva, N. V.; Os, Brusov; Олейчик, И. В.; Сизов, С В; Tyurin, I. A.

doi:10.17116/jnevro2022122121138

Cited by 1 publication

(2 citation statements)

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“…More recently, Shilov et al [ 89 ] measured the concentration of CA and 3-hydroxyanthranilic acid in the blood of 23 schizophrenic patients (depressive–delusional type) at two time points: before and after the implementation of drug treatment. These individuals were recruited when the exacerbation of the disease’s symptoms occurred.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…This study, however, possesses several limitations: (1) first of all, the methodology for the CA measurement contains several gaps, which may make this study difficult to replicate; (2) it is unclear when exactly the blood samples were collected (after, e.g., 12 h, a few days, or a few months after treatment implementation); and (3) the correlation between specific drug treatments and CA is not provided. Taking this into account, one can conclude that it is too early to point towards any final opinion about the relevance of Shilov’s findings [ 89 ].…”

Section: In Vivo Studiesmentioning

confidence: 99%

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A Review on the Role and Function of Cinnabarinic Acid, a “Forgotten” Metabolite of the Kynurenine Pathway

Gawel

2024

Cells

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In the human body, the majority of tryptophan is metabolized through the kynurenine pathway. This consists of several metabolites collectively called the kynurenines and includes, among others, kynurenic acid, L-kynurenine, or quinolinic acid. The wealth of metabolites, as well as the associated molecular targets and biological pathways, bring about a situation wherein even a slight imbalance in the kynurenine levels, both in the periphery and central nervous system, have broad consequences regarding general health. Cinnabarinic acid (CA) is the least known trace kynurenine, and its physiological and pathological roles are not widely understood. Some studies, however, indicate that it might be neuroprotective. Information on its hepatoprotective properties have also emerged, although these are pioneering studies and need to be replicated. Therefore, in this review, I aim to present and critically discuss the current knowledge on CA and its role in physiological and pathological settings to guide future studies.

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Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%