Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats

Qin, Bolin; Nagasaki, Masaru; Ren, Ming; Bajotto, Gustavo; Oshida, Yoshiharu; Sato, Yuzo

doi:10.1016/s0168-8227(03)00173-6

Cited by 259 publications

(203 citation statements)

References 35 publications

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“…Hlebowicz et al (2007) reported that cinnamon has been shown to improve insulin receptor function by activating insulin receptor PI3-kinase and inhibiting tyrosine phosphatase. Cinnamon has also been shown to stimulate the insulin receptor activity by increasing the concentrations of the phosphorylated intracellular protein IRS-1 and increasing the binding to PI3-kinase, which leads to enhanced cellular glucose uptake (Qin et al, 2003). It has been shown that cinnamon prevents the development of insulin resistance in fructose-fed rats by enhancing the insulin signaling, possibly via the nitric oxide pathway in skeletal muscle (Qin et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Mahfouz¹

2010

American Journal of Biochemistry and Biotechnology

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Cinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen male Wistar rats were divided into 3 groups of 6 rats each. Group 1; control animals received starch as control diet, while group 2; rats were fed a "highfructose diet" (60%). Group 3; fructose-fed rats received orally CE (0.5 mL/rat/day) from the 16th day of fructose feeding in experimental period. The animals were maintained in their respective groups for 30 days. At the end of the experimental period, serum levels of glucose, insulin, lipid profile, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), sialic acid and soluble Fas (sFas) were assayed. Hepatic and cardiac IRS-1 levels were also evaluated. Results: Fed high fructose diet to rats induced significant elevations in serum levels of glucose, insulin, triacylglycerol, HDL-c, sialic acid, sFas and MDA, while the level of serum TAC was significantly reduced as compared to controls. Also significant reduction in the levels of hepatic and cardiac IRS-1 were recorded as compared to controls. Oral administration of cinnamon extract to fructose-fed rats alleviated the effects of fructose and these rats showed a normal level of the parameters studied. The percentage changes of IRS-1 level in fructose-fed rats before and after treatment with CE were 38.51 for liver and 31.92% for cardiac muscle. This increase in IRS-1 level after treatment is still lowered than control level with the percentage change -11.82 and -9.93% for liver and cardiac muscle respectively. There was a significant positive correlation between IRS-1 and TAC level whereas there was negative correlation between IRS-1 and MDA, sialic acid and sFas. Conclusion: This study reports interest findings that cinnamon extract enhances glucose uptake by activating insulin receptor kinase activity in rats fed high fructose diet and it has additional roles as antioxidant and anti-inflammatory agents. Thus, clinical application of cinnamon could be considered as a potential therapeutic option in humans in the treatment of insulin resistance states. So inclusion of cinnamon in the daily diet could be recommended.

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Section: Discussionmentioning

confidence: 99%

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Mahfouz¹

2010

American Journal of Biochemistry and Biotechnology

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“…WHC: water holding capacity. 2) TBARS: thiobabituric acid reactive substances (malondialdehyde mg/kg). Table 7과 Table 8에서 보는 바와 같다.…”

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Effect of Dietary Cinnamon Powder on Savor and Quality of Chicken Meat in Broiler Chickens

박병성¹

2008

Journal of the Korean Society of Food Science and Nutrition

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A 35-day trial was carried out to determine the influence of dietary cinnamon powder (CNP) on the sensory evaluation and quality of chicken meat, carcass characteristics, plasma lipid level and growth performance of broiler chickens. There were 5 treatment groups: control; CNP 2.0%; CNP 3.0%; CNP 4.0%; and CNP 5.0%. The body weight of the broilers fed the diets containing 3.0% CNP was higher than the broilers fed the control feeds (p<0.05). The concentration of triacylglyceride, HDL-C was higher in the plasma from broiler chickens fed diets with CNP (p<0.05) but the concentrations of total cholesterol and LDL-C were significantly lower (p<0.05) compared to the control group. The carcass percentage, chicken breast and thigh weight were not different between the CNP and control groups. The WHC was significantly higher in the chickens fed 4% CNP diet, while the TBARS was significantly lower (p<0.05) in the chickens fed 3% CNP diet compared to the control group. The color of the breast muscle from the chickens fed 3% CNP diet was lighter than those from the control groups (p<0.05). The sensory evaluation of the taste and savor related to CNP in fried or boiled chicken meat were significantly better from the broiler chicken fed diets containing CNP than the control group (p<0.05). These results suggest that dietary cinnamon powder may improve savor and quality of chicken meat in broiler chickens.

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“…Several in vitro investigations reported the insulinsensitizing effect of cinnamon (1)(2)(3)(4). Using a rat model, Qin et al (5) (2) observed that when cinnamon and insulin were combined in vitro, the effect was greater than was expected, implying a synergistic relationship. Additionally, Kim et al (6) proposed that cinnamon acts by increasing endogenous insulin production, rather than by a target-based mechanism.…”

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The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes

et al. 2007

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OBJECTIVE -The purpose of this study was to determine the effect of cinnamon on glycemic control in adolescents with type 1 diabetes.RESEARCH DESIGN AND METHODS -Using a prospective, double-blind, placebocontrolled design, 72 adolescent type 1 diabetic subjects were treated in an outpatient setting with cinnamon (1 g/day) or an equivalent-appearing placebo for 90 days. A1C, total daily insulin intake, and adverse events were recorded and compared between groups.RESULTS -There were no significant differences in final A1C (8.8 vs. 8.7, P ϭ 0.88), change in A1C (0.3 vs. 0.0, P ϭ 0.13), total daily insulin intake, or number of hypoglycemic episodes between the cinnamon and placebo arms.CONCLUSIONS -Cinnamon is not effective for improving glycemic control in adolescents with type 1 diabetes. Diabetes Care 30:813-816, 2007

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Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats

Cited by 259 publications

References 35 publications

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Modulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon Extract

Effect of Dietary Cinnamon Powder on Savor and Quality of Chicken Meat in Broiler Chickens

The Effect of Cinnamon on A1C Among Adolescents With Type 1 Diabetes

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