Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization

Ghaffari, Solmaz; Varshosaz, Jaleh; Haririan, Ismaeil; Khoshayand, Mohammad Reza; Azarmi, Shirzad; Gazori, Taraneh

doi:10.1080/01932691.2011.579831

Cited by 36 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FT-IR spectrum of microalgae oil-loaded nanoparticles (PNA1, PNA2, PCH1, NAPL1) were given in Figure 1 indicates the presence of oil in the all capsules produced. 25 All these data showed that the amount of oil trapped in NAPL1, PCH1, PNA1, and PNA2 particles is highest in PNA2 by comparing with microalgal oil peaks. 26…”

Section: Ft-ir Analysismentioning

confidence: 89%

In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods

Karakaş

Şahin

İnan

et al. 2019

Biotechnology Progress

View full text Add to dashboard Cite

Reactive oxygen species can bind protein, DNA, lipids, and carbohydrates and thus cause an oxidation reaction that induces various syndromes such as cardiovascular diseases, degenerative disease, and cancer types in the human body. Bioactive compounds, such as PUFA, EPA, DHA, and carotenoids in algae, have a chain ring and protect the tissue from chemical damage and reverse the symptoms of some diseases. Algal bioactives also have various biological properties such as anticoagulants, antiviral, antiangiogenic, antitumor, anti‐inflammatory, antioxidant, antiproliferative, and immune modulation properties. This study aimed to show in vitro cytotoxic activity effect of Chlorella protothecoides and Nannochloropsis oculata microalgal extracts loaded nano–microparticles on A‐172 (Homo sapiens brain glioblastoma) and HCT‐116 (H. sapiens colon colorectal carcinoma) cell lines because of the increasing importance of algal biotechnology. MTT viability tests were performed on HUVEC, A172, and HCT 116 cells with particles obtained at optimum process parameters. The cell viability rates of encapsulated particles were also compared with pure algae extracts. Microalgal extracts loaded nano–micro particles showed very promising results for cytotoxic effect on cancer cells.

show abstract

Section: Ft-ir Analysismentioning

confidence: 89%

In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods

Karakaş

Şahin

İnan

et al. 2019

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…Choonara et al (2011) developed alginate NPs with an ionic cross-linking and reverse emulsion method [ 104 ]. Ghaffari et al [ 105 ] developed alginate–chitosan NPs encapsulating ciprofloxacin with a particle size of approximately 520 ± 16 nm. The loading efficiency of ciprofloxacin was 88%.…”

Section: Alginatementioning

confidence: 99%

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

et al. 2016

View full text Add to dashboard Cite

Abstract:In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery.

show abstract

“…The drug concentration in the supernatant was analyzed using UV spectrophotometer (Shimadzu, Japan) at 424 nm and LE% was calculated using reverse method applying following equation. 17 …”

Section: Measurement Of Drug Loading Efficiencymentioning

confidence: 99%

Sustained release Curcumin loaded Solid Lipid Nanoparticles

Jourghanian¹,

Ghaffari²,

Ardjmand³

et al. 2016

Adv Pharm Bull

Self Cite

View full text Add to dashboard Cite

Purpose: curcumin is poorly water soluble drug with low bioavailability. Use of lipid systems in lipophilic substances increases solubility and bioavailability of poorly soluble drugs. The aim of this study was to prepare curcumin loaded Solid Lipid Nanoparticles (SLNs) with high loading efficiency, small particle size and prolonged release profile with enhanced antibacterial efficacy. Methods: to synthesize stable SLNs, freeze-Drying was done using mannitol as cryoprotectant. Cholesterol was used as carrier because of good tolerability and biocompatibility. SLNs were prepared using high pressure homogenization method. Results: optimized SLNs had 112 and 163 nm particle size before and after freeze drying, respectively. The prepared SLNs had 71% loading efficiency. 90% of loaded curcumin was released after 48 hours. Morphologic study for formulation was done by taking SEM pictures of curcumin SLNs. Results show the spherical shape of curcumin SLNs. DSC studies were performed to determine prolonged release mechanism. Antimicrobial studies were done to compare the antimicrobial efficacy of curcumin SLNs with free curcumin. DSC studies showed probability of formation of hydrogen bonds between cholesterol and curcumin which resulted in prolonged release of curcumin. Lipid structure of cholesterol could cause enhanced permeability in studied bacteria to increase antibacterial characteristics of curcumin. Conclusion: the designed curcumin SLNs could be candidate for formulation of different dosage forms or cosmeceutical products.

show abstract

Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization

Cited by 36 publications

References 22 publications

In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods

In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

Sustained release Curcumin loaded Solid Lipid Nanoparticles

Contact Info

Product

Resources

About