Ciprofloxacin Release Using Natural Rubber Latex Membranes as Carrier

Abstract

Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.

Chitosan based films as supports for dual antimicrobial release

“…Several CFX delivery systems have been developed for the treatment of specific infections such as microspheres, multilamellar liposomes, hydrogels, scaffolds, implants membranes, polymer blends or nanoparticles (Aranaz et al, 2009;Budai, 2007;Cho, 2003;Chouhan & Bajpai, 2010;Dias Murbach et al, 2014;DiTizio, 1998;Koort et al, 2008;Ogawa & Plepis, 2002;Venkatasubbu, Ramasamy, Ramakrishnan, & Kumar, 2011;Verma, Bansal, Gosh, & Pandit, 2012;Wang, Dong, Du,& Kennedy, 2007).…”

Diclofenac Potassium Transdermal Patches Using Natural Rubber Latex Biomembranes as Carrier

“…Recently, the use of a polymer from NRL for TDDSs has been reported [23,24]. NRL biomembrane is an important inductor of the healing process of wounds, being used in several medical applications like prosthetics and bone grafts [25]. Moreover, the treatment of diabetic and phlebopathic ulcers with this membrane leads to a faster healing process due to a vascular growth factor found in the latex and due to a physical blockage of the entrance of new infectious agents in the treated site [26].…”

“…Moreover, the treatment of diabetic and phlebopathic ulcers with this membrane leads to a faster healing process due to a vascular growth factor found in the latex and due to a physical blockage of the entrance of new infectious agents in the treated site [26]. To summarize, the NRL biomembrane has some interesting characteristics such as easy manipulation, low cost, the ability to stimulate natural angiogenesis and cellular adhesion, being a biocompatible material, and the ability to present high mechanical resistance [25].…”

Sustained release of CIP from TiO2‐PVDF/starch nanocomposite mats with potential application in wound dressing

“…The bands at 1707 and 1622 cm −1 implies to stretching vibrations of the carbonyl group of carboxylic acid and ketone of CIP, respectively. The peaks at 1444 cm −1 , 1271 cm −1 , and 1045 cm −1 are due to C─H bending, C─C─C of ketone, and C─F, respectively . The FTIR spectrum of TiO 2 /CIP reveals the thorough loading of substitutions since all the mentioned peaks of CIP and TiO 2 NPs are extant.…”