Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis

Fang, Yong; Cailing, E; Wu, Shixing; Meng, Zhe; Qin, Guifang; Rong-ying, Wang

doi:10.1007/s10616-021-00496-x

Cited by 8 publications

(5 citation statements)

References 39 publications

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“… 19 Circ-Insulin Like Growth Factor 1 Receptor ( circIGF1R ) silencing, through regulation of the MicroRNA-194-5p/Cyclin Dependent Kinase 1 ( CDK1 ) axis, inhibits keratinocyte proliferation, migration, and invasion, and induces apoptosis. 20 Knockdown of Pituitary Tumor-Transforming 2 ( PTTG2 ) leads to the downregulation of vimentin and upregulation of E-cadherin, thereby enhancing the vitality and migration of keratinocytes. 21 siRNA silencing of MIR31 Host Gene ( MIR31HG ) induces cell cycle arrest at the G2/M phase and inhibits proliferation.…”

Section: Targeting Keratinocytesmentioning

confidence: 99%

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

Zhao,

Wei

et al. 2024

ITT

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Psoriasis is a chronic inflammatory skin disease characterized by the excessive proliferation of keratinocytes and heightened immune activation. Targeting pathogenic genes through small interfering RNA (siRNA) therapy represents a promising strategy for the treatment of psoriasis. This mini-review provides a comprehensive summary of siRNA research targeting the pathogenesis of psoriasis, covering aspects such as keratinocyte function, inflammatory cell roles, preclinical animal studies, and siRNA delivery mechanisms. It details recent advancements in RNA interference that modulate key factors including keratinocyte proliferation (Fibroblast Growth Factor Receptor 2, FGFR2 ), apoptosis (Interferon Alpha Inducible Protein 6, G1P3 ), differentiation (Grainyhead Like Transcription Factor 2, GRHL2 ), and angiogenesis (Vascular Endothelial Growth Factor, VEGF ); immune cell infiltration and inflammation (Tumor Necrosis Factor-Alpha, TNF-α ; Interleukin-17, IL-17 ); and signaling pathways ( JAK-STAT , Nuclear Factor Kappa B, NF-κB ) that govern immunopathology. Despite significant advances in siRNA-targeted treatments for psoriasis, several challenges persist. Continued scientific developments promise the creation of more effective and safer siRNA medications, potentially enhancing the quality of life for psoriasis patients and revolutionizing treatments for other diseases. This article focuses on the most recent research advancements in targeting the pathogenesis of psoriasis with siRNA and explores its future therapeutic prospects.

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Section: Targeting Keratinocytesmentioning

confidence: 99%

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

Zhao,

Wei

et al. 2024

ITT

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“…The miRNAs mediate post-transcriptional silencing through partial complementary binding to the 3′un-translated region (UTR) of the target mRNA. Decreased expression of some miRNAs has been observed in immune-mediated inflammatory skin lesions including OLP [ 192 , 193 , 194 ] psoriasis [ 194 , 195 , 196 ], and atopic eczema [ 197 , 198 , 199 , 200 , 201 ] compared to healthy non-lesional skin. In OLP, Wang et al employed HaCaT keratinocytes stimulated with lipopolysaccharide (LPS) to mimic the OLP immune environment and examined, under OLP-like settings, the role of miR-125b in the growth and apoptosis of keratinocytes.…”

Section: Role Of the Pi3k-akt-mtor And Related Network In Skin Develo...mentioning

confidence: 99%

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Roy

Boateng

Uddin

et al. 2023

Cells

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The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, and vitiligo, and is associated with poor treatment outcomes. Improved comprehension of the consequences of the dysregulated PI3K/Akt/mTOR pathway in patients with inflammatory dermatoses has resulted in the development of novel therapeutic approaches. Nonetheless, more studies are necessary to validate the regulatory role of this pathway and to create more effective preventive and treatment methods for a wide range of inflammatory skin diseases. Several studies have revealed that certain natural products and synthetic compounds can obstruct the expression/activity of PI3K/Akt/mTOR, underscoring their potential in managing common and persistent skin inflammatory disorders. This review summarizes recent advances in understanding the role of the activated PI3K/Akt/mTOR pathway and associated components in immune-mediated inflammatory dermatoses and discusses the potential of bioactive natural products, synthetic scaffolds, and biologic agents in their prevention and treatment. However, further research is necessary to validate the regulatory role of this pathway and develop more effective therapies for inflammatory skin disorders.

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“…For example, hsa_circ_0061012 was involved in IL−22-induced HaCaT cell proliferation, migration, and invasion by sponging miR−194-5p [ 117 ]. IL−22 treatment in HaCaT cells upregulated hsa_circ_IGF1R expression, and similar to hsa_circ_0061012, circ-IGF1R promoted HaCaT cell proliferation, migration, and invasion and suppressed HaCaT cell apoptosis by targeting the miR−194-5p – CDK1 axis [ 125 ]. Furthermore, hsa_circ_0060531 was also significantly increased in IL−22-stimulated HaCaT cells, and knocking down hsa_circ_0060531 suppressed IL−22-induced HaCaT cell proliferation, migration, and inflammation by modulating the miR−330-5p – GAB1 pathway [ 126 ].…”

Section: Circrnas and Psoriasismentioning

confidence: 99%

Implications of LncRNAs and CircRNAs in psoriasis: a review

Shi

Jiang

et al. 2023

RNA Biology

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Psoriasis is a chronic inflammatory skin disease characterized by skin infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) and circular RNAs (circRNAs), comprise the majority of genome transcripts and are important influencers of gene transcription and post-transcription modulations. Emerging roles of ncRNAs in psoriasis were identified recently. This review summarizes the existing studies of psoriasis-related lncRNAs and circRNAs. A considerable proportion of the studied lncRNAs and circRNAs regulate keratinocyte mobility, such as keratinocyte proliferation and differentiation. Some lncRNAs and circRNAs are tightly related to keratinocyte inflammation reactions. Other reports demonstrated that they are also implicated in modulating immune cell differentiation, proliferation, and activation. This review might illuminate future psoriasis research and highlight that lncRNAs and circRNAs might act as therapeutic targets.

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Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis

Cited by 8 publications

References 39 publications

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

Implications of LncRNAs and CircRNAs in psoriasis: a review

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