Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR‐197‐3p/PFKFB3 axis

Wang, Wei; Zhou, Lijiang; Li, Zheng; Lin, Guanhong

doi:10.1111/jgh.15829

Cited by 9 publications

(7 citation statements)

References 48 publications

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“…32 Circ 0014130 controls the miR-197-3p/ PFKFB3 axis, which is beneficial for colorectal cancer medication treatment and controls the 5-FU resistance of the disease. 33 Circ 0000064, meantime, can contribute to the development of gastric cancer through controlling miR-621/ SYF2. 34 Potential treatment options for glioblastoma may include inhibiting the signal transduction that circFGFR1 induces in the hsa-miR-224-5p/CXCR4 pathway.…”

Section: ■ Discussionmentioning

confidence: 99%

“…For instance, circ_0078710 accelerates the progress of liver cancer by targeting miR-431-5p to regulate the expression of TXNDC5 . Circ 0014130 controls the miR-197-3p/PFKFB3 axis, which is beneficial for colorectal cancer medication treatment and controls the 5-FU resistance of the disease . Circ 0000064, meantime, can contribute to the development of gastric cancer through controlling miR-621/SYF2 .…”

Section: Discussionmentioning

confidence: 99%

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CircSETBP1 Acts as a MiR-149-5p Sponge to Promote Intramuscular Fat Deposition by Regulating CRTCs

Liu

Dou

et al. 2022

J. Agric. Food Chem.

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Circular RNAs (circRNAs) appear to be crucial in the process of adipogenesis according to mounting data. CircSETBP1 is a newly discovered circRNA associated with adipogenesis. Sequencing verification and RNase R treatment have confirmed the circular nature of circSETBP1 in porcine tissue. The precise function and mechanism of circSETBP1 in adipocyte biology are still unclear. Cell counting kit-8 (CCK8), Oil red O staining, and quantitative real-time polymerase chain reaction (qRT-PCR) were employed in this investigation to reveal the functions of circSETBP1 and miR-149-5p in the growth and development of porcine intramuscular (IM) preadipocytes. CircSETBP1 overexpression accelerated cell differentiation while reducing cell proliferation. The opposite outcome was produced by overexpressing miR-149-5p. Meanwhile, circSETBP1 down-regulated the expression of miR-149-5p and miR-149-5p restrained the expression of CRTC1/CRTC2. CircSETBP1 was directly targeted by miR-149-5p, and CRTC1/CRTC2 were the target genes of miR-149-5p using bioinformatic analysis, the dual-Luciferase reporter system, and qRT-PCR. In conclusion, circSETBP1 controls the proliferation and differentiation of porcine IM preadipocytes and 3T3-L1 cells by regulating the miR-149-5p/CRTCs axis. The results of this study not only illuminate the molecular mechanism of circSETBP1/miR-149-5p involved in the deposition of porcine intramuscular fat (IMF), but they also provide a significant theoretical reference for raising quality of pork.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CircSETBP1 Acts as a MiR-149-5p Sponge to Promote Intramuscular Fat Deposition by Regulating CRTCs

Liu

Dou

et al. 2022

J. Agric. Food Chem.

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“…A variety of circRNAs have been confirmed to be related to CRC development. circ_0014130 acted as a molecular sponge for miR-197-3p and participated in the drug sensitivity and development of colorectal cancer by regulating the miR-197-3p/PFKFB3 axis [ 20 ]. Downregulation of circ_0011385 in colorectal cancer inhibited cell proliferation and promoted apoptosis by regulating the miR-330-3p/MYO6 axis [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis

Huang

Bai

Wang

et al. 2022

Analytical Cellular Pathology

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Background. The mortality rate of colorectal cancer (CRC) ranks second. circRNAs are abnormal expression in some diseases, and their dysregulation is associated with cancer progression. Recent studies have shown that the malignant progression of colorectal cancer is inseparable from the abnormal expression of circRNAs. Methods. First, the circ_0052184 expression in clinical tissue and cell samples was analyzed by qRT-PCR. Then, we constructed circ_0052184-silenced CRC cells and detected by qRT-PCR. Furthermore, the proliferation ability of cells was detected by colony formation assay. Cell migration ability was tested by wound healing assay and transwell assay. Cell invasion ability was detected by transwell assay. Results. Expression of circ_0052184 was significantly increased in colorectal cancer cell lines and tissues. Silencing circ_0052184 affected the proliferation, migration, and invasion of colorectal cancer cells. miR-604 was targeted by circ_0052184. The downstream target of miR-604 was HOXA9, and silencing circ_0052184 inhibited HOXA9 expression. The existence of the circ_0052184/miR-604/HOXA9 regulatory network in colorectal cancer was validated. circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis. Conclusions. Our study revealed that the molecular mechanism of circ_0052184 regulated the miR-604/HOXA9 axis, which might promote the malignant progression of colorectal cancer cells.

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“…A variety of circRNAs have been con rmed to be related to CRC development. circ_0014130 acted as a molecular sponge for miR-197-3p and participate in the drug sensitivity and development of colorectal cancer by regulating the miR-197-3p/PFKFB3 axis [20]. Downregulation of circ_0011385 in colorectal cancer inhibited cell proliferation, and promoted apoptosis by regulating the miR-330-3p/MYO6 axis [21].…”

Section: Discussionmentioning

confidence: 99%

circ_0052184 promotes colorectal cancer progression via targeting miR-604/HOXA9 axis

Huang

Bai

Wang

et al. 2022

Preprint

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Background:The mortality rate of colorectal cancer (CRC) ranks second. CircRNAs are abnormal expression in some diseases, and their dysregulation is associated with cancer progression. Recent studies have shown that the malignant progression of colorectal cancer is inseparable from the abnormal expression of circRNAs.Methods:First, the circ_0052184 expression in clinical tissue and cell samples was analyzed by qRT-PCR. Then, we constructed circ_0052184-silenced CRC cells and detected by qRT-PCR. Furthermore, the proliferation ability of cells was detected by colony formation assay. Cell migration ability was tested by wound healing assay and transwell assay. Cell invasion ability were detected by transwell assay.Results:Expression of circ_0052184 was significantly increased in colorectal cancer cell lines and tissues. Silencing circ_0052184 affected the proliferation, migration and invasion of colorectal cancer cells. MiR-604 was targeted by circ_0052184. The downstream target of miR-604 was HOXA9, and silencing circ_0052184 inhibited HOXA9 expression. The existence of circ_0052184/miR-604/HOXA9 regulatory network in colorectal cancer was validated. Circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis.Conclusions:Our study revealed that the molecular mechanism of circ_0052184 regulated the miR-604/HOXA9 axis, which might promote the malignant progression of colorectal cancer cells.

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Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR‐197‐3p/PFKFB3 axis

Cited by 9 publications

References 48 publications

CircSETBP1 Acts as a MiR-149-5p Sponge to Promote Intramuscular Fat Deposition by Regulating CRTCs

CircSETBP1 Acts as a MiR-149-5p Sponge to Promote Intramuscular Fat Deposition by Regulating CRTCs

circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis

circ_0052184 promotes colorectal cancer progression via targeting miR-604/HOXA9 axis

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