Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR‐21‐5p/TXNIP axis

Zhao, Yi; Wan, Yu; He, Tianzhen

doi:10.1002/jcla.24366

Clinical Laboratory Analysis

2022

DOI: 10.1002/jcla.24366

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Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR‐21‐5p/TXNIP axis

Yi Zhao

Yu Wan

Tianzhen He

Abstract: Lung cancer is one of the most common malignant tumors globally. 1 According to the World Health Organization (WHO), approximately 9.6 million people died from cancer worldwide in 2018. 2 The cancers with higher mortality rates are lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, and breast cancer. 2 Currently, surgery, radiotherapy, and chemotherapy are the three main lung cancer treatments, which are still relatively conservative. 3 Lung cancer patients cannot be treated accordingly … Show more

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Cited by 6 publications

References 51 publications

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Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

Susanti,

Dafip,

Mustikaningtyas

et al. 2024

Cell Biology International

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Hypoxia‐induced heterogeneity in colorectal cancer (CRC) significantly impacts patient survival by promoting chemoresistance. These conditions alter the regulation of miRNAs, key regulators of crucial processes like proliferation, apoptosis, and invasion, leading to tumor progression. Despite their promising potential as diagnostic and therapeutic targets, the underlying mechanisms by which miRNAs influence hypoxia‐mediated tumorigenesis remain largely unexplored. This study aims to elucidate the action of miRNAs in HCT‐116 colorectal cancer stem cells (CSCs) under hypoxia, providing valuable insights into their role in tumor adaptation and progression. MiRNA expression was determined using Nanostring nCounter, and bioinformatic analysis was performed to explain the molecular pathway. A total of 50 miRNAs were obtained with an average count of ≥ 20 reads for comparative expression analysis. The results showed that hypoxia‐affected 36 oncomiRs were increased in HCT‐116, and 14 suppressor‐miRs were increased in MSCs. The increase in miRNA expression occurred consistently from normoxia to hypoxia and significantly differed between mesenchymal stem cells (MSCs) and HCT‐116. Furthermore, miR‐16‐5p and miR‐29a‐3p were dominant in regulating the p53 signaling pathway, which is thought to be related to the escape mechanism against hypoxia and maintaining cell proliferation. More research with a genome‐transcriptome axis approach is needed to fully understand miRNAs’ role in adapting CRC cells and MSCs to hypoxia. Further research could focus on developing specific biomarkers for diagnosis. In addition, anti‐miR can be developed as a therapy to prevent cancer proliferation or inhibit the adaptation of cancer cells to hypoxia.

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Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

Susanti,

Dafip,

Mustikaningtyas

et al. 2024

Cell Biology International

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show abstract

Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR‐21‐5p/TXNIP axis

Zhao

Wan

2022

Clinical Laboratory Analysis

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Lung cancer is one of the most common malignant tumors globally. 1 According to the World Health Organization (WHO), approximately 9.6 million people died from cancer worldwide in 2018. 2 The cancers with higher mortality rates are lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, and breast cancer. 2 Currently, surgery, radiotherapy, and chemotherapy are the three main lung cancer treatments, which are still relatively conservative. 3 Lung cancer patients cannot be treated accordingly due to the lack of apparent characteristics of the early stage of lung cancer. The primary treatment for patients with advanced lung cancer is radiotherapy

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A detection model of testis‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients

Lv,

Yang,

et al. 2024

Andrology

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BackgroundMicrodissection testicular sperm extraction is an effective method to retrieve sperm from non‐obstructive azoospermia patients. However, its successful rate is less than 50%.ObjectivesTo identify the predictive value of circular RNAs in serum for sperm retrieval rate in non‐obstructive azoospermia patients.Materials and methods180 non‐obstructive azoospermia patients were recruited in this study, including 84 individuals with successful sperm retrieval and 96 individuals with failed sperm retrieval. Our study contained two phases. First, 20 patients, selected from the 180 patients, were included in screening cohort. In this cohort, the top 20 circular RNAs from our previous testicular circRNA profiles were verified between successful and failed sperm retrieval groups using real‐time polymerase chain reaction. Six circular RNAs with the most significantly different expressions were selected for further verification. Second, the 180 patients were included as discovery cohort to verify the six circular RNAs. Circular RNAs were extracted from serum in each participant. Logistic regression analysis was further performed to identify the predictive value and the area under the curve analysis was used to evaluate diagnostic efficiency, sensitivity, and specificity.ResultsSix circular RNAs including hsa_circ_0058058, hsa_circ_0008045, hsa_circ_0084789, hsa_circ_0000550, hsa_circ_0007422, and hsa_circ_0004099 showed aberrant expressions between the successful and failed sperm retrieval group. In addition, both single‐circular RNA panels and multi‐circular RNA panels were finally verified to be significant in predicting sperm retrieval rate. Notably, multi‐circular RNAs panels demonstrated better predictive abilities compared with single‐circRNA panels, and the combined panel of six‐circular RNAs (risk score = 1.094×hsa_circ_0058058+0.697×hsa_circ_0008045+0.718×hsa_circ_0084789‐0.591×hsa_circ_0000550‐0.435×hsa_circ_0007422‐1.017×hsa_circ_0004099‐1.561) exhibited the best predictive ability in the present study with an AUC of 0.977, a sensitivity of 91.7% and a specificity of 86.5%. A higher risk score indicated a higher risk of failure in sperm retrieval.Discussion and conclusionOur study was the first to report that testis‐derived circular RNAs in serum have the ability to predict sperm retrieval rate in non‐obstructive azoospermia patients, whether it is a single‐circular RNA or a combination of multi‐circular RNAs.

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Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR‐21‐5p/TXNIP axis

Cited by 6 publications

References 51 publications

Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR‐21‐5p/TXNIP axis

A detection model of testis‐derived circular RNAs in serum for predicting testicular sperm retrieval rate in non‐obstructive azoospermia patients

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