Circadian Advantages in Elite Athletes

Brager, Allison J.; Gordon, Joseph A.; Rouska, Ashton; Moore, Brian A.; Mysliwiec, Vincent

doi:10.1007/s40675-022-00239-0

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Personalized medicine based on circadian rhythms may be complex to implement on a large scale. (24)Developing and getting regulatory approval for drugs with circadian-based dosing can be challenging. Clinical trials need to demonstrate safety and efficacy in relation to the circadian rhythm, which may require more extensive studies.…”

Section: Circadian-driven Drug Development: Challengesmentioning

confidence: 99%

Chronopharmacology in cancer treatment: Optimizing drug timing for improved efficacy and reduced toxicity

Redlin Jani Rajan,

Dhivyaprasath Palaniappan

2024

Open Access Res. J. Biol. Pharm.

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Cancer treatment has seen remarkable advancements in recent years, but the accompanying side effects often diminish the patient's quality of life. To address this, the field of chronopharmacology has emerged, aiming to optimize cancer treatment by aligning it with the patient's circadian rhythms. This article explores the intricate relationship between the circadian clock and cancer susceptibility, the role of clock genes in tumor suppression, and the potential benefits of chronopharmacological approaches in chemotherapy and targeted therapies. Moreover, it discusses how chronobiological insights can be applied to palliative care and hormonal therapies, and how a patient-centered approach can tailor treatments to individual circadian rhythms. The regulatory and ethical considerations surrounding chronopharmacology are also examined. Ultimately, chronopharmacology offers the promise of more personalized and effective cancer treatments, enhancing patient well-being and outcomes in the battle against cancer.

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Section: Circadian-driven Drug Development: Challengesmentioning

confidence: 99%