Circadian clock genes and the transcriptional architecture of the clock mechanism

Cox, Kimberly

doi:10.1530/jme-19-0153

Cited by 320 publications

(277 citation statements)

References 120 publications

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“…In mammals, the SCN clock can work through various neural and endocrine inputs to peripheral tissues to align the sleep-wake cycle with behavioral and physiological oscillations, including body temperature, hormone levels, feeding, and metabolism [106,107]. Neurons have been shown to play an important role in reproduction [108,109].…”

Section: Neural Regulationmentioning

confidence: 99%

Circadian Clock, Time-Restricted Feeding and Reproduction

Pan

Taylor

Cohen

et al. 2020

IJMS

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The goal of this review was to seek a better understanding of the function and differential expression of circadian clock genes during the reproductive process. Through a discussion of how the circadian clock is involved in these steps, the identification of new clinical targets for sleep disorder-related diseases, such as reproductive failure, will be elucidated. Here, we focus on recent research findings regarding circadian clock regulation within the reproductive system, shedding new light on circadian rhythm-related problems in women. Discussions on the roles that circadian clock plays in these reproductive processes will help identify new clinical targets for such sleep disorder-related diseases.

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Section: Neural Regulationmentioning

confidence: 99%

Circadian Clock, Time-Restricted Feeding and Reproduction

Pan

Taylor

Cohen

et al. 2020

IJMS

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“…Deletion of a GR element in the promoter of αENaC revealed a role for repressive regulation (Lin et al, 1999). Likewise, circadian clock proteins such as PER1 interact with E-box elements to mediate positive and negative effects on gene expression (Cox and Takahashi, 2019). Promoter analysis of the gonadotropin-releasing hormone demonstrated a key role for the E-box elements and a repressive role for PER1 (Resuehr et al, 2007).…”

Section: Figure 8 | Ko Of Edn1-as Regulatory Elements Results In Incrmentioning

confidence: 99%

EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells

et al. 2020

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Endothelin-1 (ET-1) is a peptide hormone that functions as a vasoconstrictor in the vasculature, whereas in the collecting duct of the kidney it exerts blood pressurelowering effects via natriuretic actions. Aberrant ET-1 signaling is associated with several pathological states including hypertension and chronic kidney disease. ET-1 expression is regulated largely through transcriptional control of the gene that encodes ET-1, EDN1. Here we report a long, non-coding RNA (lncRNA) that appears to be antisense to the EDN1 gene, called EDN1-AS. Because EDN1-AS represents a potential novel mechanism to regulate ET-1 expression, we examined the regulation of EDN1-AS expression and action. A putative glucocorticoid receptor response (GR) element upstream of the predicted EDN1-AS transcription start site was identified using the ENCODE database and the UCSC genome browser. Two homozygous deletion clones of the element were generated using CRISPR/Cas9. This deletion resulted in a significant increase in the expression of EDN1-AS, which was associated with increased secretion of ET-1 peptide from HK-2 cells (two-fold increase in KO cells vs. CNTL, n = 7, P < 0.05). Phenotypic characterization of these CRISPR clones revealed a difference in cell growth rates. Using a standard growth assay, we determined that the KO1 clone exhibited a three-fold increase in growth over 8 days compared to control cells (n = 4, P < 0.01) and the KO2 clone exhibited a two-fold increase (n = 4, P < 0.01). These results support a role for EDN1-AS as a novel regulatory mechanism of ET-1 expression and cellular proliferation.

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“…The circadian clock regulates an ample range of physiological, developmental and metabolic processes ensuring that they are appropriately phased in concordance with the cellular demands [ 2 ]. The mechanisms responsible for the generation of the rhythms are quite complex and involve the orchestrated expression and function of key essential components [ 3 , 4 ]. This molecular oscillator is exquisitely connected with synchronizing cues to timely drive the rhythms of the biological processes or rhythmic outputs controlled by the clock [ 5 ].…”

Section: The Plant Circadian Clockmentioning

confidence: 99%

Chromatin Dynamics and Transcriptional Control of Circadian Rhythms in Arabidopsis

Maric

Más

2020

Genes

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Circadian rhythms pervade nearly all aspects of plant growth, physiology, and development. Generation of the rhythms relies on an endogenous timing system or circadian clock that generates 24-hour oscillations in multiple rhythmic outputs. At its bases, the plant circadian function relies on dynamic interactive networks of clock components that regulate each other to generate rhythms at specific phases during the day and night. From the initial discovery more than 13 years ago of a parallelism between the oscillations in chromatin status and the transcriptional rhythms of an Arabidopsis clock gene, a number of studies have later expanded considerably our view on the circadian epigenome and transcriptome landscapes. Here, we describe the most recent identification of chromatin-related factors that are able to directly interact with Arabidopsis clock proteins to shape the transcriptional waveforms of circadian gene expression and clock outputs. We discuss how changes in chromatin marks associate with transcript initiation, elongation, and the rhythms of nascent RNAs, and speculate on future interesting research directions in the field.

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Circadian clock genes and the transcriptional architecture of the clock mechanism

Cited by 320 publications

References 120 publications

Circadian Clock, Time-Restricted Feeding and Reproduction

Circadian Clock, Time-Restricted Feeding and Reproduction

EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells

Chromatin Dynamics and Transcriptional Control of Circadian Rhythms in Arabidopsis

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