Circadian desynchronization in pregnancy of Golden hamster following long time light exposure: Involvement of Akt/FoxO1 pathway

Das, Megha; Monhanty, Soumya Ranjan; Minocha, Tarun; Mishra, Nitesh; Yadav, Sanjeev Kumar; Haldar, Chandana

doi:10.1016/j.jphotobiol.2022.112508

Cited by 9 publications

(10 citation statements)

References 50 publications

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“…staying up late) severely disrupt people's normal biological rhythms 2,3 . The increasing incidence of hypertension, diabetes, metabolic syndrome, tumor, polycystic ovary syndrome, miscarriage, infertility, and so on has been shown to be closely related to circadian rhythm disorders 1,4–7 …”

Section: Introductionmentioning

confidence: 99%

“…2,3 The increasing incidence of hypertension, diabetes, metabolic syndrome, tumor, polycystic ovary syndrome, miscarriage, infertility, and so on has been shown to be closely related to circadian rhythm disorders. 1,[4][5][6][7] Female reproductive activities are regulated by hypothalamic-pituitary-gonadal (HPG) axis. Luteinization plays an important role in maintaining the female menstrual cycle, embryo implantation, pregnancy, and regulation of local immune environment in the uterus.…”

Section: Introductionmentioning

confidence: 99%

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Continuous light exposure influences luteinization and luteal function of ovary in ICR mice

Li¹,

Zhu²,

Zhang³

et al. 2022

Journal of Pineal Research

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuous light exposure influences luteinization and luteal function of ovary in ICR mice

Li¹,

Zhu²,

Zhang³

et al. 2022

Journal of Pineal Research

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“…For example, in rats, BMAL1 mRNA expression is highest in the presence of light and Per2 mRNA expression is highest when in the absence of light ( 36 ). Long-term light exposure desynchronizes the clock genes ( BMAL1, clock, Per1, Per2, Cry1 and Cry2 ) in the central (hypothalamus containing SCN) and peripheral (ovary and uterus) organs of hamsters, thus affecting ovarian hormone regulation, embryo implantation and pregnancy success rates ( 37 ). A BMAL1 KO can cause reproductive disorders in mice.…”

Section: Cr Regulation Of Metabolism and Fertilitymentioning

confidence: 99%

Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms

Chen

Huang²,

Wang³

et al. 2022

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is a reproductive dysfunction associated with endocrine disorders and is most common in women of reproductive age. Clinical and/or biochemical manifestations include hyperandrogenism, persistent anovulation, polycystic ovary, insulin resistance, and obesity. Presently, the aetiology and pathogenesis of PCOS remain unclear. In recent years, the role of circadian rhythm changes in PCOS has garnered considerable attention. Changes in circadian rhythm can trigger PCOS through mechanisms such as oxidative stress and inflammation; however, the specific mechanisms are unclear. Exosomes are vesicles with sizes ranging from 30–120nm that mediate intercellular communication by transporting microRNAs (miRNAs), proteins, mRNAs, DNA, or lipids to target cells and are widely involved in the regulation of various physiological and pathological processes. Circadian rhythm can alter circulating exosomes, leading to a series of related changes and physiological dysfunctions. Therefore, we speculate that circadian rhythm-induced changes in circulating exosomes may be involved in PCOS pathogenesis. In this review, we summarize the possible roles of exosomes and their derived microRNAs in the occurrence and development of PCOS and discuss their possible mechanisms, providing insights into the potential role of exosomes for PCOS treatment.

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“…Dysfunction in the clock alters the expressions of these clock‐controlled tumor‐related genes and their downstream cellular pathways, hence, contributing to carcinogenesis, activated Per2 that promotes tumor by inducing C‐Myc overexpression and lowered expression of Per1 as a link with endometrial cancer, antiphase expressions of Cry1 and Bmal1 causes ovarian cancer, and so forth 5,17–19 . Previously we have reported that long duration of light in circadian desynchronization leads to pregnancy anomalies of hamsters 20 . Therefore, we may suggest that both melatonin and clock genes are involved in the initiation and progression of gynecological cancers, while the Bmal 1 and Aanat genes are worth targeting for the etiology of artificial light‐associated endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…5,[17][18][19] Previously we have reported that long duration of light in circadian desynchronization leads to pregnancy anomalies of hamsters. 20 Therefore, we may suggest that both melatonin and clock genes are involved in the initiation and progression of gynecological cancers, while the Bmal1 and Aanat genes are worth targeting for the etiology of artificial light-associated endometrial cancer. The current study was aimed to investigate the influence of long light duration/light shift conditions on circadian rhythm genes, Bmal1 and Aanat, and also on the important marker genes of endometrial adenocarcinoma, that is, oncogenic kinase (PKCα), Akt, 14-3-3, vascular epithelial growth factor (VEGF), progesterone (P4) and its receptor, PR along with melatonin level in female hamsters.…”

Section: Introductionmentioning

confidence: 99%

Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm

Das

Haldar

Yadav

2023

Journal of Pineal Research

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Female night-workers get exposed to frequent light shifts, hence have altered circadian rhythm and are at high risk of endometrial cancer; the underlying mechanism however is still not clear. We, therefore examined the effect of long light exposure (16L:8D, LD1) and regular shift (8 h) in long nighttime (LD2) on endometrial changes of female golden hamsters. Morphometric analysis, scanning electron microscopy imaging, alcian blue staining, and cytological nuclear atypia of endometrial stromal cells confirmed the incidence of endometrial adenocarcinoma in LD2 exposed hamsters. But, less severe pathomorphological alterations were noted in uterus of LD1 exposed hamsters. Altered Aanat and Bmal1 mRNA, melatonin rhythm, downregulation of important marker gene of adenocarcinoma like Akt, 14-3-3, and PR protein expression and upregulation PKCα, pAkt-S473 and vascular epithelial growth factor (VEGF) were observed in LD2 exposed hamsters suggesting the endometrial adenocarcinoma. Further, our western blot analysis supported the immunohistochemical localization of PR, PKCα, and VEGF in uterine tissues along low progesterone. Overall, our data indicates that light shift and long light exposure potentially induced endometrioid adenocarcinoma via activation of PKC-α/Akt pathway in female hamsters. Therefore, duration of light is essential for female normal uterine function.

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Circadian desynchronization in pregnancy of Golden hamster following long time light exposure: Involvement of Akt/FoxO1 pathway

Cited by 9 publications

References 50 publications

Continuous light exposure influences luteinization and luteal function of ovary in ICR mice

Continuous light exposure influences luteinization and luteal function of ovary in ICR mice

Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms

Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm

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