Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

Qvist, Per; Stephan, Carsten; Pedersen, Brian Juel; Schlemmer, Annette; Christiansen, Claus

doi:10.1016/s8756-3282(02)00791-3

Cited by 291 publications

(207 citation statements)

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“…Putative synchronizing hormones include parathyroid hormone, melatonin, glucocorticoids and food-dependent peptides, such as glucagon-like peptide 2 [5][6][7][8][9][10][11][12]. Expression of clock genes in osteoblasts has recently been demonstrated, and is consistent with the concept of a bone peripheral clock [13,14].…”

Section: Introductionmentioning

confidence: 81%

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

et al. 2007

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Summary The variability of serum osteoprotegerin (OPG) and soluble RANKL (sRANKL) along the 24-h cycle was assessed in 20 healthy women. No rhythmic variations of serum OPG, sRANKL or sRANKL/OPG ratio were detected as a group phenomenon. Timing of sampling is unlikely to influence the results of measurements of circulating OPG and sRANKL. Introduction Physiological bone turnover shows diurnal variations. The aim of the study was to assess variability of OPG and sRANKL serum levels along the 24-h cycle. Methods Blood was collected from 20 healthy women (median age 31 years, range 25-65 years) at 4-h intervals between 08:00 and 24:00 and at 2-h intervals between 24:00 and 08:00. Serum albumin, cortisol, osteocalcin (OC), Cterminal telopeptide of type I collagen (CTX), OPG and total sRANKL were measured. Temporal variations were assessed by the COSINOR model. Results Circadian rhythms of cortisol and albumin documented a normal synchronization within the circadian structure. Serum OC and CTX showed rhythmic variations, peaking at night-time. Rhythmic variations of serum OPG, sRANKL and sRANKL/OPG ratio were not detected as a group phenomenon. On an individual basis, rhythmic changes were detected in ten patients for OPG and eight patients for sRANKL, with very small amplitudes and heterogeneous acrophases. Conclusions The absence of consistent rhythmic variations of circulating OPG and sRANKL levels may reflect the absence of rhythmic variations of their expression in the bone microenvironment. Were this the case, the nocturnal rise of bone resorption should be accounted for by different, not RANKL/OPG-mediated factors. Since circulating OPG and sRANKL may derive from sources other than bone, rhythmicity could be masked by non-rhythmic or nonsynchronized rhythmic expression in these sources. Timing of sampling is unlikely to influence the results of measurements of circulating OPG and sRANKL.

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Section: Introductionmentioning

confidence: 81%

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

et al. 2007

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“…Details regarding the effects of these dose regimens on serum cortisol profiles and quality of life of this cohort have been published previously, and this protocol has been described in detail in the work of Behan et al (19). To control for circadian variation and food intake effect on bone turnover markers (20,21), the subjects fasted from midnight during the admission and the morning dose of HC was withheld until the completion of venous sampling for bone turnover markers between 0730 and 0800 h (see below). Samples were centrifuged at 3000 r.p.m.…”

Section: Methodsmentioning

confidence: 99%

Low-dose hydrocortisone replacement therapy is associated with improved bone remodelling balance in hypopituitary male patients

Behan

Kelleher²,

Hannon³

et al. 2014

European Journal of Endocrinology

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Objective: Glucocorticoid (GC) therapy is associated with adverse effects on bone metabolism, yet the effects of different GC physiological replacement regimens in hypopituitarism are not well characterised. We aimed to assess the effect of three hydrocortisone (HC) replacement dose regimens on bone turnover. Study design: An open cross-over study randomising ten hypopituitary men with severe ACTH deficiency to three commonly used HC dose regimens: dose A (20 mg mane and 10 mg tarde), dose B (10 mg mane and 10 mg tarde) and dose C (10 mg mane and 5 mg tarde). Methods: Following 6 weeks of each regimen, the participants underwent 24-h serum cortisol sampling and measurement of bone turnover markers: bone-specific alkaline phosphatase, procollagen type I N-propeptide (PINP), intact osteocalcin (OC(1-49)), C-terminal cross-linking telopeptide (CTX-I) and tartrate-resistant acid phosphatase 5b (TRACP5b). Bone remodelling balance was estimated as an absolute ratio (PINP:CTX-I) and as an index using standardised scores derived from the matched controls. Results: There were significant increases in the concentrations of the formation markers PINP (PZ0.045) and OC(1-49) (PZ0.006) and in the PINP:CTX-I ratio (PZ0.015), and a more positive bone remodelling balance index (PZ0.03) was observed in patients on the lowest dose C than in those on the highest dose A. Mean 24-h cortisol concentrations correlated negatively with CTX-I (rZK0.66 and PZ0.04) and TRACP5b (rZK0.74 and PZ0.01) in patients on dose B and with OC(1-49) (rZK0.66 and PZ0.04) and CTX-I (rZK0.81 and P!0.01) in patients on dose C. In patients receiving the lower-dose regimen, trough cortisol concentrations correlated with increased bone formation and resorption. Conclusion: Low-dose HC replacement (10 mg mane and 5 mg tarde) is associated with increased bone formation and a positive bone remodelling balance. This may have a long-term beneficial effect on bone health.

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“…After 3 h, the most important decrease of s-CTX was observed for milk and after 6 h for Glycollagen. A part of the s-CTX decrease could be explained by the circadian variation in bone resorption (Qvist et al, 2005) or by intake of food, as was observed in maltodextrin group. It could not be attributable to an increased calcitonin secretion, since similar doses of calcium in another study did not alter serum calcitonin concentration (Reginster et al, 1993).…”

Section: Discussionmentioning

confidence: 72%

Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption

Lamotte

Boukandoura

et al. 2007

Eur J Clin Nutr

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Background/Objective: Calcium is essential for the bone metabolism but daily calcium requirements are not met in a significant proportion of the population. Fortunately, oral calcium supplementation can help to meet these needs; however, the calcium bioavailability depends on the calcium sources. The calcium absorption and bioavailability of dietary supplements from marine sources are not known. The objectives of this study were to evaluate the effects of two marine dietary supplements with a high calcium content: a fishbone powder (Phoscalim) and a ray cartilage hydrolysate (Glycollagene), in comparison with milk, and a placebo (maltodextrin), on calcium metabolism and a biochemical marker of bone resorption, using the oral calcium tolerance test. Subjects: Twenty male volunteers were randomized to eat 836 mg of calcium from different sources compared to maltodextrin during a Latin square study. Serum calcium concentrations and other parameters of the calcium metabolism, such as serum intact parathyroid hormone (iPTH) and serum C telopeptides (s-CTX), were measured after an acute oral calcium load based on the Pak protocol. Results: An increase in serum-corrected calcium areas under the curve (AUC) occurred with Phoscalim and Glycollagene when compared to milk. Significantly lower iPTH concentrations were observed with Glycollagene than with milk at T0 þ 1 h, T0 þ 3 h, T0 þ 6 h and with Phoscalim than with milk at T0 þ 6 h. A significantly lower s-CTX concentration was observed with Glycollagene than with milk and Phoscalim at T0 þ 6 h. Furthermore, the urinary calcium/creatinine ratio increased significantly more with Glycollagen than with milk in T0 h þ 3 h and T3 h þ 6 h. Conclusion: These two dietary supplements from marine sources constitute oral calcium sources when compared to milk on calcium absorption and bone resorption markers on short time.

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Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

Cited by 291 publications

References 21 publications

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

Variations along the 24-hour cycle of circulating osteoprotegerin and soluble RANKL: a rhythmometric analysis

Low-dose hydrocortisone replacement therapy is associated with improved bone remodelling balance in hypopituitary male patients

Effects of two marine dietary supplements with high calcium content on calcium metabolism and biochemical marker of bone resorption

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