Circadian variation of tissue plasminogen activator and its inhibitor, von Willebrand factor antigen, and prostacyclin stimulating factor in men with ischaemic heart disease.

Bridges, A. B.; McLaren, M.; Scott, N.; Pringle, T. H.; Mcneill, G. P.; Belch, J J F

doi:10.1136/hrt.69.2.121

Cited by 76 publications

(39 citation statements)

References 21 publications

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“…2 In the morning, sympathetic activity 10,27-29 and platelet aggregability increase while plasma fibrinolytic activity decreases. [30][31][32][33][34][35][36][37] These changes result in altered hemostasis and an imbalance between myocardial oxygen supply and demand, potentially leading to AMI. Other changes noted in the morning, especially with assumption of the upright posture, include increased heart rate, sympathetic tone, renin activity, and plasma concentrations of cortisol, epinephrine, norepinephrine, and angiotensin II.…”

Section: Resultsmentioning

confidence: 99%

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Kanth

Ittaman

Rezkalla

2013

Clinical Medicine & Research

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Objective: Nearly four decades ago, a circadian pattern of acute myocardial infarction (AMI) with a peak in the early morning waking hours was described. The goal of the present study was to determine whether major changes in lifestyle and significant advances in medical therapy have altered this pattern in the intervening years. Design: Retrospective chart review.Setting: Tertiary care hospital in central Wisconsin. Methods:We examined circadian patterns of ST elevation myocardial infarction (STEMI) in 519 patients diagnosed with STEMI over a 5-year period. Time of symptom onset was obtained from patient self-reports in the medical record and was recorded over 24 hours. Results:We observed a circadian pattern of STEMI occurrence with a morning peak at approximately 11:30 AM. This pattern was highly significant in patients who were not using beta-blockers (P <0.0001) and had no history of diabetes (P <0.0001), but was otherwise absent. The circadian pattern appeared to be attenuated in patients of a younger age, female gender, or who used statins or aspirin. Peak STEMI occurrence was earlier in smokers than non-smokers.Conclusions: Despite significant lifestyle changes and medical advances in the nearly four decades since a circadian pattern of AMI occurrence was first described, patients with STEMI had a circadian pattern of symptom onset with a morning peak. Use of beta-blockers and a history of diabetes mellitus abolished this pattern. Other modifying factors, including medications, age, and gender attenuated, but did not abolish, the circadian pattern.

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Section: Resultsmentioning

confidence: 99%

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Kanth

Ittaman

Rezkalla

2013

Clinical Medicine & Research

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“…For instance, in the mid 1980s, it was proved that events potentially favouring vascular occlusion, namely hypercoagulability and hypofi brinolysis, show their peaks at the time of the maximal incidence of myocardial infarction both in normal subjects and in patients with ischemic heart diseases [17][18][19][20][21] . A chronoriskbased evidence for the determination of the acute events was thereby produced.…”

Section: Discussionmentioning

confidence: 99%

Circadian pattern of acute variceal bleeding among cirrhotic Egyptian patients

Aref

Abdel-Khalek

Abdel-Aal

et al. 2009

Indian J Hematol Blood Transfus

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“…124 Fibrinolytic activity, in contrast, peaks in the afternoon and troughs in the morning. 129,134 Tissue plasminogen activator inhibitor 1 peaks at 4 am 135 and this diurnal variation persists in supine individuals. 124 Interestingly, tissue-type plasminogen activator antigen also peaks in the morning; however, tissue-type plasminogen activator activity was found to be lower in the morning due to increased tissue plasminogen activator inhibitor 1 activity.…”

Section: Other Hematologic Factorsmentioning

confidence: 99%

“…136 Indeed, a high level of tissue plasminogen activator inhibitor 1, associated with low fibrinolytic activity, was found to be an independent risk factor for first acute MI in both men and women. 137 The combination of increased platelet aggregability, 138 blood viscosity, 139 and thrombotic activity, 19 as well as decreased fibrinolytic activity, 135,[140][141][142] would not only increase the size of an otherwise nonoccluding thrombus but would also increase its resistance to thrombolysis. …”

Section: Other Hematologic Factorsmentioning

confidence: 99%

Circadian rhythm and cardiovascular disorders

Zhang¹,

Sabeh²,

Jain³

2014

CPT

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Abstract:Circadian rhythmicity affects all living organisms on earth. Central and peripheral cellular clocks have the ability to oscillate and be entrained to environmental cues, thus allowing organisms to anticipate and synchronize their physiologic processes and behavior to recurring daily environmental alterations. Disruption of the circadian rhythm in modern life, such as by shift work and jet travel, leads to dyssynchrony of the central and peripheral clocks, and is an independent risk factor for cardiovascular disease and the metabolic syndrome. Aging has also been associated with attenuated cellular rhythmicity. Here we summarize the clinical observations linking cardiovascular health to circadian rhythm. In addition, we discuss recent advances in experimental models for understanding the clock machinery in terms of a variety of physiologic processes within the cardiovascular system. Together, these studies build the foundation for applying our knowledge of circadian biology to the development of novel therapy for cardiovascular disorders.

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Circadian variation of tissue plasminogen activator and its inhibitor, von Willebrand factor antigen, and prostacyclin stimulating factor in men with ischaemic heart disease.

Abstract: Objectives-To determine whether plasma concentrations of tissue plasminogen activator antigen, vonWillebrand factor antigen, and prostacyclin stimulating factor and plasminogen activator inhibitor activity show circadian variation in men with ischaemic heart disease.

Cited by 76 publications

References 21 publications

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Circadian Patterns of ST Elevation Myocardial Infarction in the New Millennium

Circadian pattern of acute variceal bleeding among cirrhotic Egyptian patients

Circadian rhythm and cardiovascular disorders

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