Circadian variations in the liver metabolites of medaka (Oryzias latipes)

Fujisawa, Koichi; Takami, Taro; Kimoto, Yoshitaka; Matsumoto, Toshihiko; Yamamoto, Naoki; Terai, Shuji; Sakaida, Isao

doi:10.1038/srep20916

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…The sex-biased pattern depicted in our transcriptomic analyses appears acutely congruent and even more contrasted than our global proteome investigation. These strong sex-biases testify of the intensity of the female liver efforts for the gene expression and the synthesis of the oocyte precursor proteins 8 14 , and the involvement of the male liver in steroid hormone and metabolism processes 22 , such as urea and energy cycles 9 , respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In this work, we were interested in identifying the molecular sexual dimorphism in the liver of adult medaka fish and illustrating its implication in response to hepatotoxic exposures. Small fish such as the Japanese medaka ( Oryzias latipes ) have emerged as useful vertebrate model organisms, suitable for studying various physiological processes 9 , toxicological mechanisms 10 and also ecotoxicological effects 11 . Medaka fish presents the advantages of small size, established models produced from inbred lines, rapid development and growth, high fecundity, omnivorousness, and also shows sugar and lipid metabolic profiles similar to those of mammals 9 .…”

mentioning

confidence: 99%

“…Small fish such as the Japanese medaka ( Oryzias latipes ) have emerged as useful vertebrate model organisms, suitable for studying various physiological processes 9 , toxicological mechanisms 10 and also ecotoxicological effects 11 . Medaka fish presents the advantages of small size, established models produced from inbred lines, rapid development and growth, high fecundity, omnivorousness, and also shows sugar and lipid metabolic profiles similar to those of mammals 9 . By developing an integrative approach comprising histology and different high-throughput omic investigations ( i.e.…”

mentioning

confidence: 99%

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Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach

Qiao

Manach

Sotton

et al. 2016

Sci Rep

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Sexual dimorphism describes the features that discriminate between the two sexes at various biological levels. Especially, during the reproductive phase, the liver is one of the most sexually dimorphic organs, because of different metabolic demands between the two sexes. The liver is a key organ that plays fundamental roles in various physiological processes, including digestion, energetic metabolism, xenobiotic detoxification, biosynthesis of serum proteins, and also in endocrine or immune response. The sex-dimorphism of the liver is particularly obvious in oviparous animals, as the female liver is the main organ for the synthesis of oocyte constituents. In this work, we are interested in identifying molecular sexual dimorphism in the liver of adult medaka fish and their sex-variation in response to hepatotoxic exposures. By developing an integrative approach combining histology and different high-throughput omic investigations (metabolomics, proteomics and transcriptomics), we were able to globally depict the strong sexual dimorphism that concerns various cellular and molecular processes of hepatocytes comprising protein synthesis, amino acid, lipid and polysaccharide metabolism, along with steroidogenesis and detoxification. The results of this work imply noticeable repercussions on the biology of oviparous organisms environmentally exposed to chemical or toxin issues.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach

Qiao

Manach

Sotton

et al. 2016

Sci Rep

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“…Lactate in the muscle exhibited the same dynamics pattern as the zebrafish 40 . In medaka liver, the amount of malate and fumarate decreased in night time 44 . TCA cycle and glycolysis is a major pathway for the generation of ATP, which is thought to be consumed during the day than at night.…”

Section: Discussionmentioning

confidence: 94%

Trans-omics approaches used to characterise fish nutritional biorhythms in leopard coral grouper (Plectropomus leopardus)

Mekuchi

Sakata

Yamaguchi³

et al. 2017

Sci Rep

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Aquaculture is now a major supplier of fish, and has the potential to be a major source of protein in the future. Leopard coral groupers are traded in Asian markets as superior fish, and production via aquaculture has commenced. As feeding efficiency is of great concern in aquaculture, we sought to examine the metabolism of leopard coral groupers using trans-omics approaches. Metabolic mechanisms were comprehensively analysed using transcriptomic and metabolomic techniques. This study focused on the dynamics of muscular metabolites and gene expression. The omics data were discussed in light of circadian rhythms and fasting/feeding. The obtained data suggest that branched-chain amino acids played a role in energy generation in the fish muscle tissues during fasting. Moreover, glycolysis, TCA cycles, and purine metabolic substances exhibited circadian patterns, and gene expression also varied. This study is the first step to understanding the metabolic mechanisms of the leopard coral grouper.

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“…Furthermore, the zebrafish is an excellent model to study development processes because its embryos are transparent, and it has a high reproduction rate, with close metabolic and physiological resemblance to other vertebrates [ 41 ]. Medaka models are produced from inbred lines and are characterized by high fecundity, rapid development and growth, and metabolic profiles of lipids and sugars which are close to mammals [ 42 ].…”

Section: Liver Sexual Dimorphism and Hepatic Sexually Dimorphic Gene Expressionmentioning

confidence: 99%

Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver

et al. 2021

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The liver is a vital organ that sustains multiple functions beneficial for the whole organism. It is sexually dimorphic, presenting sex-biased gene expression with implications for the phenotypic differences between males and females. Estrogens are involved in this sex dimorphism and their actions in the liver of several reptiles, fishes, amphibians, and birds are discussed. The liver participates in reproduction by producing vitellogenins (yolk proteins) and eggshell proteins under the control of estrogens that act via two types of receptors active either mainly in the cell nucleus (ESR) or the cell membrane (GPER1). Estrogens also control hepatic lipid and lipoprotein metabolisms, with a triglyceride carrier role for VLDL from the liver to the ovaries during oogenesis. Moreover, the activation of the vitellogenin genes is used as a robust biomarker for exposure to xenoestrogens. In the context of liver diseases, high plasma estrogen levels are observed in fatty liver hemorrhagic syndrome (FLHS) in chicken implicating estrogens in the disease progression. Fishes are also used to investigate liver diseases, including models generated by mutation and transgenesis. In conclusion, studies on the roles of estrogens in the non-mammalian oviparous vertebrate liver have contributed enormously to unveil hormone-dependent physiological and physiopathological processes.

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Circadian variations in the liver metabolites of medaka (Oryzias latipes)

Cited by 14 publications

References 23 publications

Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach

Deep sexual dimorphism in adult medaka fish liver highlighted by multi-omic approach

Trans-omics approaches used to characterise fish nutritional biorhythms in leopard coral grouper (Plectropomus leopardus)

Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver

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