CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling

Zhang, Yinbin; Shan, Changyou; Chen, Yinxi; Sun, Shiyu; Liu, Di; Zhang, Xin; Zhang, Shuqun

doi:10.3389/fgene.2020.00987

Cited by 18 publications

(17 citation statements)

References 42 publications

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“…The protein encoded by CCNE1 gene participates and plays an important role in G1/S cell-cycle regulation. Recent study has found that the CCNE1 gene could serve as an oncogene and a poor prognostic factor in ovarian cancer and lung cancer (10)(11)(12). However, CCNE1 gene mutation has not been reported in BA or CMPT so far.…”

Section: Discussionmentioning

confidence: 98%

Multiple Bronchiolar Adenomas With Malignant Transformation and CCNE1 Mutation: a Case Report and Literature Review

Hui

et al. 2021

Preprint

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Background: Bronchiolar adenoma (BA) is a recently proposed diagnostic terminology, which is considered as the expansion of the concept of ciliated muconodular papillary tumors (CMPT). BA is considered to be a benign neoplasm, but a few previous cases have been reported with the possibility of malignant transformation. Therefore，the genetic and histological nature of BA is controversial so far. We describe a rare case of multiple BAs with malignant transformation and CCNE1（cyclin E1）mutation to increase the understanding of this disease.Case description: A 56-year-old woman was admitted to our hospital due to two ground-glass nodules (GGNs) in the left lung detected by chest CT without symptom. The pure GGN located in the upper lingual segment about 6 mm in diameter and another mixed GGN located in the dorsal segment about 7 mm. The two GGNs have been found a year ago without treatment, and the mixed GGN become larger to 8 mm with vacuole sign in the next year health checkup. We performed a wedge resection of the two nodules completely by video-assisted thoracoscopy (VATS). Postoperative pathology indicated that the pure GGN was atypical bronchial adenoma, while the mixed GGN was atypical bronchial adenoma with malignant transformation which was missed in frozen section. Gene mutations analysis by next-generation sequencing (NGS) showed CCNE1 gene mutation in both lesions, and her-2 mutation was identified in the mixed GGN. The programmed cell death 1 ligand 1 (PD-L1) expression analysis of tumor cells showed 0% and less than 1% in the pure GGN and the mixed GGN, respectively. Conclusion: BA is generally considered to be a benign tumor. The present study indicated that BA may be carcinogenic in atypical cases with some driver genes mutation and we should be vigilant for its potentiality of malignant transformation in clinical practice.

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Section: Discussionmentioning

confidence: 98%

Multiple Bronchiolar Adenomas With Malignant Transformation and CCNE1 Mutation: a Case Report and Literature Review

Hui

et al. 2021

Preprint

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“…Besides, CCNE1 and CHEK1 were proved to be related with the connection of the cell cycle and P53 and PI3K/AKT pathways. The study has also found that CCNE1 is one key gene which is enriched in P53 pathways, and the report of Zhang et al has also suggested that circDENND2A can regulate the activity of P53 pathways in lung cancer through the miR-34a/CCNE1 axis [ 26 , 27 ]. In addition, CHEK1 has been confirmed to have a direct link with P53 in colon cancer, and inhibited CHEK1 could significantly promote the apoptosis of P53-knockdown cancer cells [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis Reveals the Related Role of miR-511-5p in the Progression of Breast Cancer

Wang

Zhong

Zhang

et al. 2022

Journal of Healthcare Engineering

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Breast cancer remains a dangerous disease, and delving the molecular mechanism of breast cancer is still necessary. To illustrate the role of miR-511-5p, TCGA database was used to excavate the abundance of miR-511-5p, and the miR-511-5p level was measured in the pathological tissues and tumor cell lines. Moreover, the targets of miR-511-5p were identified with miRDIP and GEPIA and then were used for functional enrichment analysis. Besides, the targets of miR-511-5p were analyzed with the protein-protein interaction (PPI) network for the hub nodes, and then the expression levels of the hub nodes were visualized with the GEPIA database. The results showed that miR-511-5p was significantly downregulated in multiple types of tumor samples in the online database, and the downregulated miR-511-5p was also found in pathological tissues and tumor cell lines. Moreover, 48 genes were identified as the potential targets of miR-511-5p by miRDIP and GEPIA databases and enriched in cell cycle, PI3K/AKT, and P53 pathways. Besides, seven genes including BRCA1, FN1, CCNE1, CCND1, CHEK1, BUB3, and CDC25A were identified as the hub nodes by the PPI network, and CCNE1 and CHEK1 were confirmed to be related with the prognostic survival of the patients with breast cancer. In conclusion, the proofs in this study suggest that reduced miR-511-5p was a biomarker event for breast cancer, and CCNE1 and CHEK1 served as potential targets of miR-511-5p to involve the progression of breast cancer.

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“…lncRNA-microRNA-associated ceRNA has been confirmed as an important mode in progress of TNBC (Yang et al, 2018 ; Dong et al, 2020 ; Li et al, 2020 ), and CCNE1-associated ceRNA regulation appeared in several cancers (Zhang et al, 2019 , 2020 ). Thus, we inferred that lncRNA-microRNA-associated ceRNA hypothesis provided potential possibility of CCNE1 dysregulation in TNBC.…”

Section: Discussionmentioning

confidence: 99%

Long Non-coding RNA SENP3-EIF4A1 Functions as a Sponge of miR-195-5p to Drive Triple-Negative Breast Cancer Progress by Overexpressing CCNE1

Chen

Miao

et al. 2021

Front. Cell Dev. Biol.

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Triple-negative breast cancer (TNBC) has high malignancy and limited treatment, so novel molecular therapeutic targets are urgently needed. Cyclin E1 (CCNE1) promotes progression in breast cancer, but its role and inherent mechanisms in TNBC are yet to be elucidated. Competing endogenous RNA (ceRNA) may be a potential mechanism. CCNE1 was selected though bioinformatics and clinical samples, and cell lines were utilized to verify CCNE1 expression by qRT-PCR and western blot. Predicting tools provided potential miR-195-5p and SENP3-EIF4A1 and tested from multilevel. Functional experiments were conducted in vitro and in vivo. Luciferase reporter assay and RNA immunoprecipitation experiments were implemented to ensure the interaction between miR-195-5p and SENP3-EIF4A1/CCNE1 in TNBC. Bioinformatics found DNA hypermethylation of miR-195-5p and preliminarily verified. Mechanistically, SENP3-EIF4A1-miR-195-5p-associated ceRNA could drive TNBC progress though regulating CCNE1. DNA hypermethylation of miR-195-5p might be another reason. In summary, SENP3-EIF4A1-miR-195-5p-CCNE1 axis promotes TNBC progress and may contribute to the novel diagnosis and treatment of TNBC.

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CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling

Cited by 18 publications

References 42 publications

Multiple Bronchiolar Adenomas With Malignant Transformation and CCNE1 Mutation: a Case Report and Literature Review

Multiple Bronchiolar Adenomas With Malignant Transformation and CCNE1 Mutation: a Case Report and Literature Review

Bioinformatics Analysis Reveals the Related Role of miR-511-5p in the Progression of Breast Cancer

Long Non-coding RNA SENP3-EIF4A1 Functions as a Sponge of miR-195-5p to Drive Triple-Negative Breast Cancer Progress by Overexpressing CCNE1

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