circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107/BDNF Signaling Pathway

Hong, Weijun; Zhang, Yajuan; Ding, Jingyi; Yang, Qilian; Xie, Haixiang; Gao, Xiwen

doi:10.1155/2020/6075902

Cited by 19 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, circHIPK3 was upregulated in CC and accelerated multiplication of CC cells via the miR-485-3p/FGF2 axis (10). Meanwhile, circHIPK3 enhanced the progression of NSCLC via the miR-107/BDNF signaling pathway (11). CircRNA HIPK3 upregulated CCND2 expression in OSCC via miR-124, thus promoting cell proliferation and invasion (12).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have found that CircHIPK3 is related to tumor progression, indicating that CircHIPK3 can regulate tumor progression. An increasing number of studies have demonstrated the involvement of circHIPK3 in the progression of cervical cancer (CC), nonsmall-cell lung cancer (NSCLC), and OSCC as an oncogene (10)(11)(12). However, the mechanism of circHIPK3 in OSCC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637

Jiang¹,

Zhang²,

Zhang³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: To investigate the expression, function, and related mechanisms of circHIPK3 in oral squamous cell carcinoma (OSCC). Methods: CircHIPK3 expression was determined by quantitative reverse transcription polymerized chain reaction (QRT-PCR) in OSCC and adjacent tissues, and the correlation between the circHIPK3 level and clinicopathological indexes of OSCC was analyzed. CircHIPK3 expressions in different OSCC cell lines were detected, cell counting kit-8 (CCK-8) and 5-bromodeoxyuridine (BrdU) assays were utilized to monitor cell proliferation and activity. Flow cytometry was adopted to detect apoptosis and transwell assay was used to detect cell invasion. The expressions of nuclear protein 1 (NUPR1), phosphatidylinositol 3 kinase (PI3K)/ protein kinase B (AKT) (PI3K/AKT) pathway proteins, and E-cadherin, Vimentin, and N-cadherin markers of epithelial-mesenchymal transformation (EMT) were detected by Western blot or Quantitative Real-time PCR (QRT-PCR).Results: Upregulated circHIPK3 was noted in OSCC tissues (compared with adjacent tissues), and its overexpression was related to OSCC size and histopathological grade. Functionally, overexpressed circHIPK3 can significantly promote EMT, proliferation, and invasion of OSCC cells and can inhibit cell apoptosis in vivo and in vitro. In addition, CircHIPK3 upregulated the activation of NUPR1 and PI3K/AKT. Bioinformatics analyses showed that miR-637 was the common target of circHIPK3 and NUPR1, while a dual luciferase reporting assay and RIP assay further demonstrated that circHIPK3 targeted miR-637 and bound to 3' UTR of NUPR1.Conclusions: CircHIPK3 demonstrates potential as a prognostic marker of OSCC and mediates OSCC progression via the miR-637-mediated NUPR1/PI3K/AKT axis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637

Jiang¹,

Zhang²,

Zhang³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Further study ( 63 ) demonstrated that circHIPK3 induced cell proliferation and inhibited apoptosis in NSCLC by sponging miR-149, indirectly increasing FOXM1 expression. Similarly, Hong et al ( 64 ) confirmed that circHIPK3 promoted NSCLC progression via a circHIPK3/miR-107/brain-derived neurotrophic factor (BDNF) axis, highlighting potential markers for NSCLC screening. A study by Chen et al ( 65 ) demonstrated that circHIPK3 functioned as an oncogene, and loss of circHIPK3 significantly impaired cell proliferation, migration and invasion, and induced protective autophagy via a miR-124-3p/STAT3/protein kinase AMP-activated catalytic subunit a2/AMPKa axis in serine/threonine kinase 11-mutant LC cell lines (A549 and H838; Fig.…”

Section: Circhipk3 and Human Diseasesmentioning

confidence: 92%

Emerging landscape of circHIPK3 and its role in cancer and other diseases (Review)

et al. 2021

View full text Add to dashboard Cite

Circular RNAs (circRNAs) are a special class of recently re-discovered RNAs, which are covalently closed ring RNA molecules. circRNAs have been reported to possess multiple functions and are considered crucial regulators of several processes, and are therefore gaining increasing attention. In recent years, increasing evidence has shown that circRNAs are implicated in several crucial biological processes via regulation of gene expression, and their dysregulation is also associated with the development of numerous diseases, particularly acting as oncogenic or tumor-suppressor molecules in cancer. Furthermore, circRNAs are involved in cell proliferation, differentiation, apoptosis, invasion and metastasis. In the present review, the biogenesis and functions of circRNAs are described, with a focus on the most recent research advances and the emerging roles of circular homeodomain-interacting protein kinase 3 (circHIPK3) in human diseases. The present review may provide novel avenues for research on the roles of circHIPK3 as a clinical diagnostic and prognostic biomarker, as well as highlighting promising therapeutic targets for certain diseases and cancer. Contents 1. Introduction 2. Biogenesis of circRNAs 3. Biological functions of circRNAs 4. circHIPK3 and human diseases 5. Conclusions and future perspectives

show abstract

“… 94 circHIPK3 Up miR-107 H1299, A549, and BEAS-2B NSCLC cell lines circHIPK3 promotes the migration and proliferation of NSCLC cells by sponging miR-107 to upregulate BDNF expression Hong et al. 95 circ_0074027 up miR-335-5p 60 NSCLC tissue samples; H358, H1299, H1581, and A549 NSCLC cell lines circ_0074027 promotes cell viability, cell-cycle process, and colony formation and inhibits apoptosis in NSCLC cells by sponging miR-335-5p to increase GUL4B expression Yu et al. 96 circSEC31A up miR-376a 44 NSCLC tissue samples; A549 and H1299 NSCLC cell lines circSEC31A promotes NSCLC cell migration, invasion, and glycolysis and inhibits apoptosis by sponging miR-376a to increase SEC31A expression Cheng et al.…”

Section: Overview Of Circrnasmentioning

confidence: 99%

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Liu

et al. 2022

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with covalently closed-loop structures, a high abundance, and tissue-specific expression patterns. They participate in various pathophysiological processes by regulating complex gene networks involved in proliferation, apoptosis, migration, and epithelial-to-mesenchymal transition (EMT), as well as metastasis. A growing number of studies have revealed that the dysregulation of circRNAs contributes to many aspects of cancer progression, such as its occurrence, metastasis, and recurrence, suggesting their great potential as efficient and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC. In this review, we systematically elucidate the characteristics, biogenesis, and functions of circRNAs and focus on their molecular mechanisms in NSCLC progression. Moreover, we highlight their clinical implications in NSCLC treatment.

show abstract

circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107/BDNF Signaling Pathway

Cited by 19 publications

References 31 publications

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637

CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637

Emerging landscape of circHIPK3 and its role in cancer and other diseases (Review)

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Contact Info

Product

Resources

About