CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool

Zhou, Jiang; Wang, Baisheng; Bin, Xin; Xie, Changqing; Li, Bo; Liu, Ousheng; Tang, Zhangui

doi:10.3389/fmed.2021.615417

Cited by 18 publications

(21 citation statements)

References 68 publications

(27 reference statements)

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“…We also found high levels of circHIPK3 in MAEC-derived exosomes in an HG condition. circHIPK3 is located on chromosome 11p13, which is involved in medicating a wide range of physiological and pathological processes of cardiovascular disease [ 20 ]. HG can upregulate circHIPK3 expression in retinal EC.…”

Section: Discussionmentioning

confidence: 99%

Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway

Wang

Shi

Jiao

et al. 2021

Aging

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The abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression of diabetic vascular complications. In high-glucose (HG) conditions, endothelial cells (ECs) act as the first barrier to damaging stimuli and trigger a multi-response, including EC and VSMC crosstalk. However, the crosstalk pathways between ECs and VSMCs under HG conditions remain unclear. This study aimed to explore the roles and underlying mechanism of exosomes derived from ECs in the crosstalk between ECs and VSMCs. Our results showed that mouse aortic endothelial cell (MAEC)–secreted exosomes could promote the proliferation and inhibit the apoptosis of VSMCs induced by HG. Furthermore, we isolated the exosomes secreted by MAECs and found that exosomes derived from MAECs that were exposed to HG could transfer circHIPK3, which is enriched in MAEC-derived exosomes, to VSMCs. Exosomal circHIPK3 promoted the proliferation and inhibited the apoptosis of VSMCs. circHIPK3 sponged miR-106a-5p to relieve its repression of forkhead box O1 (Foxo1) expression. The increased expression of Foxo1 acted as a transcription factor to promote Vcam1 expression, thus facilitating the uptake of MAEC-derived exosomes by VSMCs. The results of this study suggested that exosomal circHIPK3 derived from MAECs promotes the proliferation of VSMCs induced by HG via the miR-106a-5p/Foxo1/Vcam1 pathway.

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Section: Discussionmentioning

confidence: 99%

Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway

Wang

Shi

Jiao

et al. 2021

Aging

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“…These included: circEGLN3, linear EGLN3, circABCB10, circSOD2, and circACAD11. We also selected circHIPK3, which is dysregulated in multiple cancer types, including colorectal cancer and gastric cancer (22)(23)(24). We used GAPDH mRNA as an internal control to normalize expression for each candidate RNA marker (25).…”

Section: Qpcr Assays and Data Analysismentioning

confidence: 99%

Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma

et al. 2022

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Renal cell carcinomas (RCC) are usually asymptomatic until late stages, posing several challenges for early detection of malignant disease. Non-invasive liquid biopsy biomarkers are emerging as an important diagnostic tool which could aid with routine screening of RCCs. Circular RNAs (circRNAs) are novel non-coding RNAs that play diverse roles in carcinogenesis. They are promising biomarkers due to their stability and ease of detection in small quantities from non-invasive sources such as urine. In this study, we analyzed the expression of various circRNAs that were previously identified in RCC tumors (circEGLN3, circABCB10, circSOD2 and circACAD11) in urinary sediment samples from non-neoplastic controls, patients with benign renal tumors, and clear cell RCC (ccRCC) patients. We observed significantly reduced levels of circEGLN3 and circSOD2 in urine from ccRCC patients compared to healthy controls. We also assessed the linear variant of EGLN3 and found differential expression between patients with benign tumors compared to ccRCC patients. These findings highlight the potential of circRNA markers as non-invasive diagnostic tools to detect malignant RCC.

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“…Plenty of studies have demonstrated the biogenesis of circHIPK3 and its vital roles in the progression of multiple human diseases, including cancers, cardiovascular diseases, inflammatory diseases, diabetes mellitus, etc. [ 12 , 13 ]. This review aims to provide a more detailed description of the functions of circHIPK3 and a more comprehensive overview of its diagnostic and therapeutic values in some of the aforementioned diseases.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

Yan-fei

Yang

et al. 2022

Diagnostics

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Circular RNAs (circRNAs) are a class of noncoding RNAs with closed-loop of single-stranded RNA structure. Although most of the circRNAs do not directly encode proteins, emerging evidence suggests that circRNAs play a pivotal and complex role in multiple biological processes by regulating gene expression. As one of the most popular circRNAs, circular homeodomain-interacting protein kinase 3 (circHIPK3) has frequently gained the interest of researchers in recent years. Accumulating studies have demonstrated the significant impacts on the occurrence and development of multiple human diseases including cancers, cardiovascular diseases, diabetes mellitus, inflammatory diseases, and others. The present review aims to provide a detailed description of the functions of circHIPK3 and comprehensively overview the diagnostic and therapeutic value of circHIPK3 in these certain diseases.

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CircHIPK3: Key Player in Pathophysiology and Potential Diagnostic and Therapeutic Tool

Cited by 18 publications

References 68 publications

Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway

Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway

Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

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