CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity

Chen, Shuai; Song, Peng; Wang, Yu; Wang, Zeng; Xue, Jiaming; Jiang, Yicheng; Zhou, Yan; Zhao, Jie; Tang, Liming

doi:10.1016/j.isci.2023.107756

Cited by 5 publications

(1 citation statement)

References 46 publications

(48 reference statements)

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“…Meanwhile, m 6 A modification accelerated the mature process of miR-25-3p, which acts as a molecular sponge for KLF4 and C/EBPα and could inhibit adipogenesis [ 120 ]. Two miRNAs, namely, miR-149-3p and miR-1322, could inhibit adipogenesis of BMSCs by targeting FTO [ 121 , 122 ].…”

Section: A Modification and Adipogenesis Of Bmscsmentioning

confidence: 99%

N6-Methyladenosine in Cell-Fate Determination of BMSCs: From Mechanism to Applications

Zhang,

Li,

Wang

et al. 2024

Research

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The methylation of adenosine base at the nitrogen-6 position is referred to as “N6-methyladenosine (m 6 A)” and is one of the most prevalent epigenetic modifications in eukaryotic mRNA and noncoding RNA (ncRNA). Various m 6 A complex components known as “writers,” “erasers,” and “readers” are involved in the function of m 6 A. Numerous studies have demonstrated that m 6 A plays a crucial role in facilitating communication between different cell types, hence influencing the progression of diverse physiological and pathological phenomena. In recent years, a multitude of functions and molecular pathways linked to m 6 A have been identified in the osteogenic, adipogenic, and chondrogenic differentiation of bone mesenchymal stem cells (BMSCs). Nevertheless, a comprehensive summary of these findings has yet to be provided. In this review, we primarily examined the m 6 A alteration of transcripts associated with transcription factors (TFs), as well as other crucial genes and pathways that are involved in the differentiation of BMSCs. Meanwhile, the mutual interactive network between m 6 A modification, miRNAs, and lncRNAs was intensively elucidated. In the last section, given the beneficial effect of m 6 A modification in osteogenesis and chondrogenesis of BMSCs, we expounded upon the potential utility of m 6 A-related therapeutic interventions in the identification and management of human musculoskeletal disorders manifesting bone and cartilage destruction, such as osteoporosis, osteomyelitis, osteoarthritis, and bone defect.

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Section: A Modification and Adipogenesis Of Bmscsmentioning

confidence: 99%