CircRNAs: Insights into Gastric Cancer

Rajgopal, Sanjana; Fredrick, Sherine Joanna; Parvathi, Venkatachalam Deepa

doi:10.1159/000517303

Cited by 5 publications

(10 citation statements)

References 91 publications

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“…The rapid development of biological technologies has contributed to the in‐depth exploration of functional circRNAs 17 . CircRNAs are characterized as being stable, specific, and well conserved and have been suggested to be vital participants in carcinogenesis, making them possible candidates for cancer screening 18‐20 . Accordingly, circRNAs have attracted more attention in tumor pathogenesis and biomarker research in recent years.…”

Section: Discussionmentioning

confidence: 99%

“… 17 CircRNAs are characterized as being stable, specific, and well conserved and have been suggested to be vital participants in carcinogenesis, making them possible candidates for cancer screening. 18 , 19 , 20 Accordingly, circRNAs have attracted more attention in tumor pathogenesis and biomarker research in recent years. In the field of GC, a number of abnormally expressed circRNAs have been discovered, and their functions and molecular mechanisms have been revealed.…”

Section: Discussionmentioning

confidence: 99%

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Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application

Shao

Yan

et al. 2022

Clinical Laboratory Analysis

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Background Circular RNAs (circRNAs) are thought to be vital participants in carcinogenesis and have the characteristics of being stable, specific, and well conserved. However, their clinical significance and application value in gastric cancer (GC) are still poorly understood. Hsa_circ_0086720 was found to be a dysregulated circRNA in GC by microarray screening and was further explored for its clinical significance and application. Methods Hsa_circ_0086720 was detected in GC cell lines, tissues, and plasma, and the clinicopathological correlations were investigated. The existence, stability, origin, and change in the plasma hsa_circ_0086720 level were verified in early GC patients. Moreover, receiver operating characteristic and Kaplan–Meier survival curves were constructed to analyze the diagnostic and prognostic values, and bioinformatics analysis was used to identify the potential functions. Finally, risk factors and nomogram predicting were established. Results Hsa_circ_0086720 was found to be downregulated in gastric carcinogenesis, and tissue hsa_circ_0086720 was negatively associated with perineural invasion, Borrmann type, disease‐free survival, and overall survival. Hsa_circ_0086720 was stable in circulating plasma and was actively secreted by cells in gastric carcinogenesis. As a biomarker for early GC screening, plasma hsa_circ_0086720 had good sensitivity and specificity, and its stability met the clinical application requirements. Bioinformatics analysis suggested that dysregulated hsa_circ_0086720 has important functions in gastric carcinogenesis. Univariate Cox regression analysis identified factors associated with overall survival time and disease‐free survival time. The nomograms showed good accuracy of predicting survival time. Conclusion Hsa_circ_0086720 is a novel biomarker for screening early GC and predicting the prognosis of advanced‐stage patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application

Shao

Yan

et al. 2022

Clinical Laboratory Analysis

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“…During the progress of EMT, the expression of mesenchymal markers, such as N-cadherin, vimentin, and dense protein, are increased, while the expression of epithelial markers, such as E-cadherin, is decreased. A large number of studies have shown that circRNAs can regulate EMT transcription factors (EMT-TFs: Snail, Slug, Twist, and Zeb family) and EMT-related signaling pathways (TGF-β/Smad, Wnt/β-catenin, PI3K/AKT, MEK/ERK, JAK2/STAT5 and Hedgehog signaling pathways) [29]. Herein, according to the ranking of cancer DALYs (disability-adjusted life years) from 2010 to 2019 [30], we will mainly introduce the detailed molecular mechanism of circRNA regulating the EMT pathway via sponging miRNA in the first eight solid tumors (Figure 2).…”

Section: Circrna Plays a Role In Tumorigenesis And Angiogenesis Via S...mentioning

confidence: 99%

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Guo

Jia

Luo

et al. 2022

IJMS

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Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are closely related to the carcinogenic process and play a critical role in tumor metastasis. CircRNAs can lay the foundation for tumor metastasis via promoting tumor angiogenesis, make tumor cells gain the ability of migration and invasion by regulating epithelial-mesenchymal transition (EMT), interact with immune cells, cytokines, chemokines, and other non-cellular components in the tumor microenvironment, damage the normal immune function or escape the immunosuppressive network, and further promote cell survival and metastasis. Herein, based on the characteristics and biological functions of circRNA, we elaborated on the effect of circRNA via circRNA-associated competing endogenous RNA (ceRNA) network by acting as miRNA/isomiR sponges on tumor angiogenesis, cancer cell migration and invasion, and interaction with the tumor microenvironment (TME), then explored the potential interactions across different RNAs, and finally discussed the potential clinical value and application as a promising biomarker. These results provide a theoretical basis for the further application of metastasis-related circRNAs in cancer treatment. In summary, we briefly summarize the diverse roles of a circRNA-associated ceRNA network in cancer metastasis and the potential clinical application, especially the interaction of circRNA and miRNA/isomiR, which may complicate the RNA regulatory network and which will contribute to a novel insight into circRNA in the future.

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“…A lot of research has been done on the gene expression profile of GC. The exact molecular mechanism of the GC is far from fully uncovered [9]. There is considerable need to find more potential for effective therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Identification of significant genes associated with prognosis of gastric cancer by bioinformatics analysis

Wang

Song

Liu

et al. 2022

J Egypt Natl Canc Inst

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Background Gastric cancer (GC) ranks second in mortality among all malignant diseases worldwide. However, the cause and molecular mechanism underlying gastric cancer are not clear. Here, we used integrated bioinformatics to identify possible key genes and reveal the pathogenesis and prognosis of gastric cancer. Methods The gene expression profiles of GSE118916, GSE79973, and GSE29272 were available from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between GC and normal gastric tissues were screened by R software and Venn diagram software. GO and KEGG pathway enrichment of DEGs was performed using the DAVID database. A protein-protein interaction (PPI) network was established by STRING and visualized using Cytoscape software. Then the influence of hub genes on expression and survival was assessed using TCGA database. Results A total of 83 DEGs were found in the three datasets, including 41 up-regulated genes and 42 down-regulated genes. These DEGs were mainly enriched in extracellular matrix organization and cell adhesion. The enriched pathways obtained in the KEGG pathway analysis were extracellular matrix (ECM)-receptor interaction and focal adhesion. A PPI network of DEGs was analyzed using the Molecular Complex Detection (MCODE) app of Cytoscape. Four genes were considered hub genes, including COL5A1, FBN1, SPARC, and LUM. Among them, LUM was found to have a significantly worse prognosis based on TCGA database. Conclusions We screened DEGs associated with GC by integrated bioinformatics analysis and found one potential biomarker that may be involved in the progress of GC. This hub gene may serve as a guide for further molecular biological experiments.

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CircRNAs: Insights into Gastric Cancer

Cited by 5 publications

References 91 publications

Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application

Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

Identification of significant genes associated with prognosis of gastric cancer by bioinformatics analysis

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