CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma

Zhao, Rongjie; Ni, Junjie; Si, Lu; Jiang, Sujing; You, Lixin; Líu, Hao; Shou, Jiawei; Zhai, Chongya; Zhang, Wei; Shao, Shengpeng; Yang, Xinmei; Pan, Hongming; Han, Weidong

doi:10.18632/aging.102334

Cited by 57 publications

(37 citation statements)

References 52 publications

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“…In pancreatic adenocarcinoma (PAAD), circ-UBAP2-hsa-miR-494 potentially targets CXCR4 and ZEB1 transcripts. Expression of CXCR4 and ZEB1 regulated PAAD by modulating the infiltration and function of immune cells, including TAMs [73]. CXCR4 is the chemokine receptor in tumors and chemokine CXCL12 is the specific ligand that interacts with it.…”

Section: The Crosstalk Between Circrnas and The Tme In Intravasationmentioning

confidence: 99%

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Shao

Lü

2020

Cancer Cell Int

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Background Carcinomas are highly heterogeneous with regard to various cancer cells within a tumor microenvironment (TME), which is composed of stromal cells, blood vessels, immunocytes, and modified extracellular matrix. Focus of the study Circular RNAs (circRNAs) are non-coding RNAs that are expressed in cancer and stromal cells. They are closely associated with cancer metastasis as their expression in tumor cells directs the latter to migrate to different organs. circRNAs packaged in exosomes might be involved in this process. This is particularly important as the TME acts in tandem with cancer cells to enhance their proliferation and metastatic capability. In this review, we focus on recent studies on the crosstalk between circRNAs and the TME during cancer metastasis. Conclusion We particularly emphasize the roles of the interaction between circRNAs and the TME in anoikis resistance, vessel co-option, and local circRNA expression in directing homing of exosome.

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Section: The Crosstalk Between Circrnas and The Tme In Intravasationmentioning

confidence: 99%

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

Shao

Lü

2020

Cancer Cell Int

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“…Clinical HCC samples suggested positive associations between circ-ASAP1 expression and levels of CSF-1, MAPK1, and CD68 + tumor-related-macrophages; all these could predict patient outcomes [57]. As suggested previously, Circ-UBAP2 also impacted M2 macrophages activation in the PAAD [55]. Zou Y et al initially conducted a bioinformatics study on circ-CDR1as among 868 cancer samples with RNA-seq datasets of the MiOncoCirc database.…”

Section: Circrnas In Macrophage Activationmentioning

confidence: 82%

“…The expressions of CXCR4 and ZEB1 were related to the levels of Tregulating cells (Tregs) and consumed T cells in the PAAD tissues. The expressions of CXCR4 and ZEB1 were positively related to those of CTLA-4 and PD-1 [55], indicating the circUBAP2-mediated ceRNA system regulates PAAD by regulating the infiltrating process and functions of CD8 + T cells .…”

Section: Circular Rnas In Immune Responses and Diseasesmentioning

confidence: 95%

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

Cheng

et al. 2020

Biomark Res

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Circular RNAs (circRNAs) are covalently linked RNAs that exhibit individual strand with a closed-loop framework compared with a conserving, steady and abundant linear counterpart. In recent years, as high-throughput sequencing advancement has been developing, functional circRNAs have been increasingly recognized, and more extensive analyses expounded their effect on different diseases. However, the study on the function of circRNAs in the immune system remains insufficient. This study discusses the basic principles of circRNAs regulation and the systems involved in physiology-related and pathology-related processes. The effect of circRNAs on immune regulation is elucidated. The ongoing development of circRNAs and basic immunology has multiplied their potential in treating diseases. Such perspective will summarize the status and effect of circRNAs on various immune cells in cancer, autoimmune diseases and infections. Moreover, this study will primarily expound the system of circRNAs in T lymphocytes, macrophages and other immune cells, which creates a novel perspective and lay a theoretical basis for treating diseases.

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“…The oncogenic role of circUBAP2 has already been reported and found to work as a ceRNA. circUBAP2 modulates pancreatic adenocarcinoma tumorigenesis by regulating the levels of hsa-miR-494 and the expression of CXCR4, HIF1A, ZEB1, SDC1, and TWIST1 32 . In addition, circUBAP2 modulates cancer cell malignancy through the miR-641/YAP1 axis and miR-361-3p/SOX4 axis in osteosarcoma and cervical cancer, respectively 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis

et al. 2021

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Cancer-associated fibroblasts (CAFs) are commonly acquired activated extracellular matrix (ECM)-producing myofibroblasts, a phenotypes with multiple roles in hepatic fibrogenesis and carcinogenesis via crosstalk with cohabitating stromal/cancer cells. Here, we discovered a mechanism whereby CAF-derived cytokines enhance hepatocellular carcinoma (HCC) progression and metastasis by activating the circRNA-miRNA-mRNA axis in tumor cells. CAFs secreted significantly higher levels of CXCL11 than normal fibroblasts (NFs), and CXCL11 also had comparatively higher expressions in HCC tissues, particularly in metastatic tissues, than para-carcinoma tissues. Both CAF-derived and experimentally introduced CXCL11 promoted HCC cell migration. Likewise, CAFs promoted tumor migration in orthotopic models, as shown by an increased number of tumor nodules, whereas CXCL11 silencing triggered a decrease of it. CXCL11 stimulation upregulated circUBAP2 expression, which was significantly higher in HCC tissues than para-carcinoma tissues. Silencing circUBAP2 reversed the effects of CXCL11 on the expression of IL-1β/IL-17 and HCC cell migration. Further downstream, the IFIT1 and IFIT3 levels were significantly upregulated in HCC cells upon CXCL11 stimulation, but downregulated upon circUBAP2 silencing. IFIT1 or IFIT3 silencing reduced the expression of IL-17 and IL-1β, and attenuated the migration capability of HCC cells. Herein, circUBAP2 counteracted miR-4756-mediated inhibition on IFIT1/3 via sponging miR-4756. miR-4756 inhibition reversed the effects induced by circUBAP2 silencing on the IL-17 and IL-1β levels and HCC cell migration. In orthotopic models, miR-4756 inhibition also reversed the effects on metastatic progression induced by silencing circUBAP2.

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CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma

Cited by 57 publications

References 52 publications

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis

The emerging landscape of circular RNAs in immunity: breakthroughs and challenges

Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis

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