Circular chemistry to enable a circular economy

Keijer, Tom; Bakker, Vincent; Slootweg, J. Chris

doi:10.1038/s41557-019-0226-9

Cited by 422 publications

(283 citation statements)

References 35 publications

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“…The first route we investigated involves the conversion of soil pollutant 1 into 5 . Recycling of 1 , a degradation product from the xenobiotic soil fumigant trans ‐1,3‐dichloropropene, into GABA precursors provides an interesting example of the first principle of circular chemistry and as such might be desirable for future sustainable synthesis . To this end, we selected the enzymes trans ‐3‐chloroacrylic acid dehalogenase and malonate semialdehyde decarboxylase, which are part of the metabolic pathway for the degradation of trans ‐1,3‐dichloropropene in Pseudomonas cichorii 170 .…”

Section: Discussionmentioning

confidence: 99%

In Situ Acetaldehyde Synthesis for Carboligation Reactions

2020

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The enzyme 4‐oxalocrotonate tautomerase (4‐OT) can promiscuously catalyze various carboligation reactions using acetaldehyde as a nucleophile. However, the highly reactive nature of acetaldehyde requires intricate handling, which can impede its usage in practical synthesis. Therefore, we investigated three enzymatic routes to synthesize acetaldehyde in situ in one‐pot cascade reactions with 4‐OT. Two routes afforded practical acetaldehyde concentrations, using an environmental pollutant, trans‐3‐chloroacrylic acid, or a bio‐renewable, ethanol, as starting substrate. These routes can be combined with 4‐OT catalyzed Michael‐type additions and aldol condensations in one pot. This modular systems biocatalysis methodology provides a stepping stone towards the development of larger artificial metabolic networks for the practical synthesis of important chemical synthons.

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Section: Discussionmentioning

confidence: 99%

In Situ Acetaldehyde Synthesis for Carboligation Reactions

2020

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“…A utilização de fontes renováveis de matéria-prima é um dos pilares da Química Verde (3º princípio) e também da Economia Circular, que estão intimamente inter-relacionadas e que permitirão a construção de capital econômico, natural e social. [54][55][56][57] Na manufatura, principalmente de commodities químicas e de combustíveis, existe uma necessidade pela substituição do uso dos recursos fósseis não renováveis, como petróleo, carvão e gás natural, por alternativas mais sustentáveis e de origem renovável. 58,59 Nesse contexto, a aplicação de biomassa vegetal como matéria prima torna-se um substituto ideal aos recursos fósseis, já que ela é renovável e contribuirá para reduzir o impacto ambiental gerado pela indústria petroquímica.…”

Section: Evolução Dirigida De Enzimas Na Bioeconomiaunclassified

Evolução Dirigida De Enzimas: Pequenas Modificações, Melhores Biocatalisadores

Teixeira

Milagre

2020

Quim. Nova

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Recebido em 05/11/2019; aceito em 19/03/2020; publicado na web em 24/04/2020 DIRECTED EVOLUTION OF ENZYMES: SMALL CHANGES, BETTER BIOCATALYSTS. Biocatalysis is now a mature field, both in the laboratory and industrial scale. This approach counts on enzyme high selectivity, biodegradability, elegant control over the outcome of reaction conditions and as a possible solution to address some challenges in Green Chemistry faced by synthetic organic chemists. However, many wild-type ready-to-use enzymes were not designed to accommodate the organic substrates needed by today's demands. Or they do not fit a predefined optimum process condition or even, useful reactions are not accessible because there is no enzyme counterpart for metallo-and organocatalysts. This review will give a brief introduction on the protein engineering tools (directed evolution, rational design, and semi-rational design) and will focus on directed evolution of enzymes, their impact in chemistry with examples from production of commodity chemicals to pharmaceutical intermediates and its potential as a tool to achieve greener chemistry criteria will be discussed.

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“…[3] This is what nature does with photosynthesis, andm any research ef-forts have been carried on for decades in order to achieve an artificial photosynthetic system.Innature,water and carbon dioxide are the raw materials to start with, in order to produce biomass and the solar photonsg ive the energy that activates these elaborated processes. Ideally,t he exploitation of the solar energy will lead to ac irculare conomy, [4] where the fuels are produced from the waste generated by their use, without the assistance of other types of resources if not wholly renewable. Carbon dioxide is one of the major waste products of combustion, and it is also ag reenhouse gas.…”

Section: Introductionmentioning

confidence: 99%

New Photosensitizers Based on Heteroleptic Cu^I Complexes and CO₂ Photocatalytic Reduction with [Ni^II(cyclam)]Cl₂

Gracia

Luci

Bruschi

et al. 2020

Chemistry A European J

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Earth-abundant metal complexes have been attracting increasinga ttention in the field of photo(redox)catalysis. In this work, the synthesis and full characterisation of four new heteroleptic Cu I complexes are reported, which can work as photosensitizers. The complexes bear ab ulky diphosphine (DPEPhos = bis[(2-diphenylphosphino)phenyl] ether) and ad iimine chelating ligand based on 1-benzyl-4-(quinol-2'yl)-1,2,3-triazole. Their absorption has ar elative maximum in the visible-light region, up to 450 nm. Thus, their use in photocatalytic systemsf or the reduction of CO 2 with blue light in combination with the known catalyst [Ni II (cyclam)]Cl 2 was tested.T his system produced CO as the main product through visible light (l = 420 nm) with aT ON up to 8a fter 4hours. This value is in line with other photocatalytic systemsu sing the same catalyst. Nevertheless, this system is entirely noble-metal free.

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Circular chemistry to enable a circular economy

Cited by 422 publications

References 35 publications

In Situ Acetaldehyde Synthesis for Carboligation Reactions

In Situ Acetaldehyde Synthesis for Carboligation Reactions

Evolução Dirigida De Enzimas: Pequenas Modificações, Melhores Biocatalisadores

New Photosensitizers Based on Heteroleptic Cu^I Complexes and CO₂ Photocatalytic Reduction with [Ni^II(cyclam)]Cl₂

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Circular chemistry to enable a circular economy

Cited by 422 publications

References 35 publications

In Situ Acetaldehyde Synthesis for Carboligation Reactions

In Situ Acetaldehyde Synthesis for Carboligation Reactions

Evolução Dirigida De Enzimas: Pequenas Modificações, Melhores Biocatalisadores

New Photosensitizers Based on Heteroleptic CuI Complexes and CO2 Photocatalytic Reduction with [NiII(cyclam)]Cl2

Contact Info

Product

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New Photosensitizers Based on Heteroleptic Cu^I Complexes and CO₂ Photocatalytic Reduction with [Ni^II(cyclam)]Cl₂