Circular Contrast Perimetry via Web Application

Meyerov, Joshua; Deng, Yuanchen; Busija, Lazar; Skalicky, Simon E.

doi:10.1016/j.xops.2022.100172

Cited by 4 publications

(25 citation statements)

References 32 publications

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“…46 Because of the established bias between SAP and OCCP sensitivities, OCCP sensitivities were rescaled to match SAP sensitivities for accurate ICC analysis. 24,25 Reporting ICC and the Pearson statistic is consistent with past studies comparing modalities of perimetry. 10,17,47,48 The parameters from OCCP, SAP, and OCT were compared in terms of area under the receiver operating characteristic curve (AUC), sensitivity and specificity at different cutoffs to evaluate their diagnostic accuracy.…”

Section: Discussionsupporting

confidence: 85%

“…Intraclass correlation coefficients (ICC) were calculated to assess intertest reliability and were defined as: poor (<0.5); moderate (0.5–0.75); good (0.75–0.9) or excellent (≥0.90) 46. Because of the established bias between SAP and OCCP sensitivities, OCCP sensitivities were rescaled to match SAP sensitivities for accurate ICC analysis 24,25. Reporting ICC and the Pearson statistic is consistent with past studies comparing modalities of perimetry 10,17,47,48…”

Section: Methodsmentioning

confidence: 89%

“…Current perimetry machines often cause patient anxiety, and this has been shown to adversely affect adherence and test performance 21. Offering patients an improved user experience may serve to promote patient engagement, adherence, and satisfaction 24. Improved access to care might help increase early detection rates (eg, in younger patients) or allow for more frequent monitoring (eg, in glaucoma patients at high risk of disease progression) 12.…”

Section: Discussionmentioning

confidence: 99%

“…It has been found already to have robust diagnostic metrics for glaucoma with users showing a preference for it over SAP in terms of convenience and usability. 24 A study of a normal cohort performing OCCP demonstrated consistent results sufficient to determine parameters for a normative data set. 25 As an online system accessed via the web browser on any computer, OCCP offers easier and more convenient access to perimetry, with a more enjoyable and comfortable user experience; these have the potential to improve the provision of care and improve disease surveillance outcomes.…”

mentioning

confidence: 90%

“…Online circular contrast perimetry (OCCP) has recently been developed, specifically as a means of providing perimetry on computer screens. It has been found already to have robust diagnostic metrics for glaucoma with users showing a preference for it over SAP in terms of convenience and usability 24. A study of a normal cohort performing OCCP demonstrated consistent results sufficient to determine parameters for a normative data set 25.…”

mentioning

confidence: 95%

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Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Meyerov

Deng

Busija

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: The aim was to validate and compare the diagnostic accuracy of a novel 24-degree, 52-loci online circular contrast perimetry (OCCP) application to standard automated perimetry (SAP). Design: Prospective cohort study. Methods: Two hundred and twenty participants (125 normal controls, 95 open angle glaucoma patients) were included. Agreement, correlation, sensitivity, specificity, and area under receiver operating curves (AUC) were compared for parameters of OCCP, SAP, and optical coherence tomography (OCT) for the retinal nerve fiber layer and macular ganglion cell complex inner plexiform layer. Results: Pointwise sensitivity for OCCP was greater than SAP by 1.02 log units (95% CI: 0.95–1.08); 95% limits of agreement 0.860 to 1.17. Correlation and agreement for global indices and regional zones between OCCP and SAP were strong. OCCP mean deviation (MD) AUC was 0.885±0.08, similar to other instruments’ parameters with the highest AUC: SAP MD (0.851±0.08), OCT retinal nerve fiber layer inferior thickness (0.908±0.07), OCT ganglion cell complex inner plexiform layer inferior thickness (0.849±0.08), P>0.05. At best cutoff, OCCP MD sensitivity/specificity were comparable to SAP MD (90/74 vs 94/65%). Conclusions: OCCP demonstrates similar perimetric sensitivities to SAP and similar AUC to SAP and OCT in distinguishing glaucoma patients from controls. OCCP holds promise as a glaucoma surveillance and screening tool, with the potential to be utilized for in-clinic and at-home perimetry and expand community testing.

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 90%

mentioning

confidence: 95%

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Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Meyerov

Deng

Busija

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Repeatability of Online Circular Contrast Perimetry Compared to Standard Automated Perimetry

Meyerov,

Chen,

Busija

et al. 2024

Journal of Glaucoma

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Précis: Online circular contrast perimetry has good test repeatability and reliability that is comparable with standard automated perimetry. It holds promise for use in disease screening and surveillance to expand the provision of glaucoma care. Purpose: To evaluate the repeatability of online circular contrast perimetry (OCCP) compared to standard automated perimetry (SAP) in normal participants and patients with stable glaucoma over 18 weeks. Methods: Thirty-six participants (13 normal controls and 23 patients with open angle glaucoma) were recruited. OCCP and SAP perimetry tests were performed twice at baseline, then at 6, 12, and 18 weeks. Global perimetric indices were compared between perimetry types and analyzed for short-term and intermediate-term repeatability. Results: There were no statistically significant changes over time for both OCCP and SAP across all groups for mean deviation (MD), pattern standard deviation, and visual index/visual field index (P>0.05). Test-retest intraclass correlation coefficients (ICCs) for OCCP MD were excellent at baseline (0.98, 95% CI: 0.89–0.99) and good at 18 weeks (0.88, 95% CI: 0.51–0.98). SAP test-retest ICCs were excellent at baseline (0.94, 95% CI: 0.70–0.99) and 18 weeks (0.97, 95% CI: 0.84–0.99). Inter-test ICCs were good, ranging from 0.84 to 0.87. OCCP testing time was shorter than SAP (5:29 ± 1:24 vs. 6:00 ± 1:05, P<0.001). OCCP had similar false-positive (3.84 ± 3.32 vs. 3.66 ± 4.53, P=0.48) but lower false-negative (0.73 ± 1.52 vs. 4.48 ± 5.00, P<0.001) and fixation loss responses (0.91 ± 1.32 vs. 2.02 ± 2.17, P<0.001). Conclusions: OCCP demonstrated good repeatability and reliability with similar performance indices to SAP in both the short term and intermediate term. OCCP has the potential to be utilized as a glaucoma screening and surveillance tool for in-clinic and at-home testing, expanding the provision of care.

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Online Circular Contrast Perimetry via a Web-Application: Establishing a Normative Database for Central 10-Degree Perimetry

Chen,

Meyerov,

Skalicky

2024

OPTH

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Purpose To establish a normative database using a central 10-degree grid pattern for the online circular contrast perimetry (OCCP) application. Participants Fifty participants with mean age 65 ± 13 years were selected for this study. One eye from each participant that met inclusion criteria was randomly included in the cohort. Methods The web-application delivered online 52-loci perimetry in a central 10-degree pattern using circular flickering targets. These targets consist of concentric sinusoidal alternating contrast rings. Users were guided by the application to the correct viewing distance and head position using in-built blind spot localization and webcam monitoring. A spinning golden star was used as the fixation target and patients performed the test in a darkened room following standard automated perimetry (SAP). Results The reliability rates and global indices for OCCP were similar to SAP. OCCP mean sensitivity reduced with age at a similar rate to SAP. Mean sensitivity per loci of 10-degree OCCP was greater than SAP by 1.24 log units (95% CI 1.23 to 1.26) and obeyed a physiological hill of vision. Small differences existed in mean sensitivities between OCCP and SAP which increased with increasing spot eccentricity. Mean deviation (MD) displayed good agreement between the two tests. Conclusion Central 10-degree online circular contrast perimetry via a computer-based application has comparable perimetric results to standard automated perimetry in a normal cohort.

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Circular Contrast Perimetry via Web Application

Cited by 4 publications

References 32 publications

Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Repeatability of Online Circular Contrast Perimetry Compared to Standard Automated Perimetry

Online Circular Contrast Perimetry via a Web-Application: Establishing a Normative Database for Central 10-Degree Perimetry

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