Circular Dichroism and Chelation: Complexes of N,N'-Bis (2-butan-1-ol)-ethylenediamine.

Hawkins, C. J.; Nyberg, Klas; Ekbom, K.; Borgström, Björn

doi:10.3891/acta.chem.scand.18-1564

Cited by 7 publications

(1 citation statement)

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“…It has been shown previously [31] that hydrolysed copper(II)-ethambutol complexes arise from the ionization of the alcoholic groups of the ligand resulting in tri-and tetradentate co-ordination. Assuming this to be the case, the Table 2 represents the complex shown in Figure l(b) which was originally proposed to be the effective antitubercular species in vivo [10].…”

Section: Results and Dlseusslonmentioning

confidence: 99%

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration

1981

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Formation constants for copper(II) and zinc(II) complexes of dextro-2,2'-(ethylenediimino)-di-1-butanol (ethambutol) and its metabolic oxidation product, 2,2'-(ethylenediimino)-dibutyric acid (EDBA) have been measured potentiometrically at 37 degrees C, I = 0.15 mol dm-3 [NaCl]. The constants are used in computer models to assess the extent of the formation of these complexes in vivo. These simulations indicate that whereas ethambutol forms metal complexes only to a limited extent in vivo, EDBA competes effectively under physiological conditions for copper(II) and zinc(II). This study suggests that zinc(II) binding by EDBA may account for a number of side effects of ethambutol treatment.

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Section: Results and Dlseusslonmentioning

confidence: 99%

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration

1981

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Polyaminoalkohole als bifunktionelle Extraktionsmittel für Kupfer(II)

Dinjus

Hörhold

Klee

et al. 1983

Zeitschrift anorg allge chemie

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Polyaminoalkohole, die durch Addition von mono‐ oder bifunktionellen Epoxiden an disekundäre Diamine entstehen, werden auf ihre Verwendbarkeit als Extraktionsmittel für Kupfer(II) geprüft. Während sich die einfachen Diaminodiole IV bis VI als ungeeignet erweisen, werden mit dem Polyaminoalkohol III (Verdünnungsmittel Chloroform) abhängig vom Anion in schwach saurer Lösung maximale Verteilungsverhältnisse D von 1000 gefunden. Dieser Effekt geht auf den besonderen Charakter der Kupfer(II)‐Komplexe von III zurück, die die Funktion eines Metallchelates und eines substituierten Ammoniumsalzes in sich vereinigen. Der Ammoniumteil mit seiner hohen Affinität für die Chloroformphase wirkt als Phasentransfer‐Reagenz für den Chelatteil.

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Electrochemical acetoxylation of 2-methylnaphthalene

Kowalski

Płoszyńska

1990

Electrochimica Acta

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Circular Dichroism and Chelation: Complexes of N,N'-Bis (2-butan-1-ol)-ethylenediamine.

Cited by 7 publications

References 0 publications

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration

Metal binding by pharmaceuticals. Part 1. Copper(II) and zinc(II) interactions following ethambutol administration

Polyaminoalkohole als bifunktionelle Extraktionsmittel für Kupfer(II)

Electrochemical acetoxylation of 2-methylnaphthalene

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