Circular Dichroism Studies on New Optically Active 1,5-Benzodiazepine Derivatives

Abstract

From thirty three new optically active 1,5-benzodiazepine derivatives the UV and CD data are reported and the bands discussed related to corresponding electronic transitions respectively stereochemical features.

Isolation and Characterization of Atropisomers of Seven-Membered-Ring Benzolactams

“…Seven-membered-ring benzolactams ( I ) (Figure ) have been used as the core structures of various biologically active molecules. Lofendazam ( I : X = NH), diltiazem ( I : X = S) and benazepril ( I : X = CH 2 ) are the typical therapeutic agents developed using these structures. Thus far, the conformation of these heterocycles has been extensively investigated to gain insight into the structures of these relatively flexible heterocycles .…”