Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus

Shan, K. Y.; Liu, Chang; Liu, Bai-Hui; Chen, Xue; Dong, Rui; Liu, Xin; Zhang, Yangyang; Liu, Ban; Zhang, Shujie; Wang, Jia-Jian; Zhang, Shenghai; Wu, Jihong; Zhao, Chunxia; Yan, Biao

doi:10.1161/circulationaha.117.029004

Cited by 449 publications

(350 citation statements)

References 38 publications

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“…CircRNAs are also reported to be involved in controlling cell proliferation. As referenced, circHIPK3 is an abundant circRNA derived from Exon2 of the HIPK3 gene, it sponges to nine miRNAs including miR-124, and knockdown of HIPK3 largely prevented human cell growth, which was further confirmed by another individual study in endothelial cells via miR-30a-3p-dependent mechanisms (Shan et al, 2017;Zheng et al, 2016). By performing circRNA microarray, Dang, Liu, and Li (2017) has identified 14 downregulated and 22 upregulated circRNAs in HUVECs in response to hypoxia.…”

Section: Role Of Circrnas In Akimentioning

confidence: 87%

Noncoding RNAs in acute kidney injury

Ren

Zhu

et al. 2018

Journal Cellular Physiology

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Acute kidney injury (AKI), caused by various stimuli including ischemia reperfusion, nephrotoxic insult, and sepsis, is characterized by abrupt decline of kidney function. Till now, the molecular mechanisms for AKI have not been fully explored and the effective therapies are still lacking. Noncoding RNAs (ncRNAs), a group of biomolecules function at RNA level, are involved in a wide range of physiopathological processes including AKI. MicroRNAs (miRNAs) are the most extensively studied ncRNAs in AKI. Evidence indicated that miRNAs are altered significantly in various types of AKI. Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI, indicating their therapeutic potential in AKI. In contrast, functions of long noncoding RNAs and circular RNAs in AKI are hot topics but still largely unknown. Additionally, ncRNAs packaged in exosome can be detected in circulation and urine, they may serve as specific biomarkers for AKI. This review summarized the alteration and functional role of ncRNAs and their therapeutic potential in AKI.

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Section: Role Of Circrnas In Akimentioning

confidence: 87%

Noncoding RNAs in acute kidney injury

Ren

Zhu

et al. 2018

Journal Cellular Physiology

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“…As a novel posttranscriptional regulator, circR-NAs have been reported in some cardiovascular diseases. circRNAs perform different functions in the development of aortic aneurysms (17), myocardial fibrosis (18), myocardial damage (19), diabetic retinopathy-related vascular dysfunction (20), cardiac hypertrophy and heart failure (21), and hypoxia-induced angiogenesis (22). CDKN2B-AS (an antisense noncoding RNA in the INK4 locus, ANRIL) promotes the development of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

Chang

Rong

et al. 2018

FASEB j.

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Intimal hyperplasia is a reaction to vascular injury, which is the primary reason for vascular restenosis caused by the diagnostic or therapeutic procedure for cardiovascular diseases. Circular RNAs (circRNAs) are known to be associated with several cardiovascular conditions, but the expression of circRNAs in the neointima has not been reported in detail. In this study, we established the balloon‐injured rat carotid artery model and detected the expression of circRNAs in the carotid arteries with a microarray. We found that the circRNA expression profile of the healthy carotid arteries and the injured arteries were significantly different. We investigated the role of rno‐circ_005717 (circDiaph3) in the differentiation of rat vascular smooth muscle cells (VSMCs). We found that knockdown of circDiaph3 up‐regulated the level of diaphanous‐related formin‐3 and promoted the differentiation of VSMCs to contractile type. In addition, circDiaph3 up‐regulated the transcription of Igf1r and supported the proliferation and migration of VSMCs. circDiaph3 could be a molecular target to combat intimal hyperplasia.—Xu, J.‐Y., Chang, N.‐B., Rong, Z.‐H., Li, T., Xiao, L., Yao, Q.‐P., Jiang, R., Jiang, J. circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration. FASEB J. 33, 2659–2668 (2019). http://www.fasebj.org

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“…Circ‐HIPK2 derived from HIPK2 gene exon 2 can affect the distinct roles of its target in cell autophagy by sponging miR‐124 (miR124‐2HG), thus regulating sigma nonopioid intracellular receptor 1 ( SIGMAR1/OPRS1 ) expression in astrocyte cells . However, circ‐HIPK3 derived from HIPK3 gene exon 2 can abundantly sponge miR‐558 to suppress the expression of heparanase ( HPSE ) in bladder cancer and can sponge endogenous miR‐30a‐3p in diabetes mellitus‐associated retinal vascular dysfunction …”

Section: Functions Of Circrnasmentioning

confidence: 99%

“…to suppress the expression of heparanase (HPSE) in bladder cancer and can sponge endogenous miR-30a-3p in diabetes mellitus-associated retinal vascular dysfunction. 33,34…”

Section: Mirna Sequestrationmentioning

confidence: 99%

Circular RNAs in hepatocellular carcinoma: Functions and implications

Jiang

et al. 2018

Cancer Medicine

109

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At present, as hotspot members of the noncoding RNA network, circular RNAs (circRNAs) with distinct properties and diverse pathophysiological functions are being increasingly delineated. CircRNAs play roles at the epigenetic, transcriptional and posttranscriptional regulatory levels. Major studies have focused on their functions as efficient microRNA sponges. The validated number of endogenous circRNAs involved in hepatocellular carcinoma (HCC) continues to increase. Altered circRNA expression is associated with HCC occurrence, invasion, and metastasis. Moreover, the aberrant expression of circRNAs is also significantly related to HCC tumor stage, size, differentiation and metastasis. Because they are exceptionally stable, highly conserved and have tissue‐specific expression patterns, some circRNAs, including hsa_circ_0004018, hsa_circ_0003570, and hsa_circ_0005075, may be potential markers for the diagnosis of HCC. We herein summarize the current knowledge of HCC‐associated circRNAs and present their implications for carcinogenesis and their potential value as diagnostic and prognostic biomarkers. Finally, we discuss the future directions of studies on HCC‐associated circRNAs.

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Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus

Abstract: The circular RNA circHIPK3 plays a role in diabetic retinopathy by blocking miR-30a function, leading to increased endothelial proliferation and vascular dysfunction. These data suggest that circular RNA is a potential target to control diabetic proliferative retinopathy.

Cited by 449 publications

References 38 publications

Noncoding RNAs in acute kidney injury

Noncoding RNAs in acute kidney injury

circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration

Circular RNAs in hepatocellular carcinoma: Functions and implications

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