Circular RNA 0025984 Ameliorates Ischemic Stroke Injury and Protects Astrocytes Through miR-143-3p/TET1/ORP150 Pathway

Zhou, Daixuan; Huang, Zhi; Zhu, Xianfang; Hong, Tao; Zhao, Yuanli

doi:10.1007/s12035-021-02486-8

Cited by 44 publications

(27 citation statements)

References 54 publications

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“…Knockdown of circHectd1 expression significantly attenuated astrocytic autophagy, decreased infarct areas, attenuated neuronal deficits, and ameliorated astrocyte activation in tMCAO mice [ 106 ]. A recent study also confirmed the detrimental effects of astrocyte autophagy in ischemic stroke [ 107 ].…”

Section: Autophagy In Ischemic Strokementioning

confidence: 59%

“…DEX exerts a neuroprotection against OGD-induced astrocytes injury via activation of astrocytes autophagy by regulating the TSC2/mTOR signaling pathway [ 108 ]. Circular RNA 0025984 protects astrocytes from ischemic injury via inhibition of autophagy by targeting the miR-143-3p/TET1/ORP150 pathway [ 107 ]. G1 treatment restores autophagy in astrocytes via activation of G protein-coupled receptor 30 (GRP30) and protected neurons after ischemic stroke [ 109 ].…”

Section: Figurementioning

confidence: 99%

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Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

Zhang

Ding

et al. 2022

Oxidative Medicine and Cellular Longevity

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Stroke is one of the leading causes of death and disability worldwide. Autophagy is a conserved cellular catabolic pathway that maintains cellular homeostasis by removal of damaged proteins and organelles, which is critical for the maintenance of energy and function homeostasis of cells. Accumulating evidence demonstrates that autophagy plays important roles in pathophysiological mechanisms under ischemic stroke. Previous investigations show that autophagy serves as a “double-edged sword” in ischemic stroke as it can either promote the survival of neuronal cells or induce cell death in special conditions. Following ischemic stroke, autophagy is activated or inhibited in several cell types in brain, including neurons, astrocytes, and microglia, as well as microvascular endothelial cells, which involves in inflammatory activation, modulation of microglial phenotypes, and blood-brain barrier permeability. However, the exact mechanisms of underlying the role of autophagy in ischemic stroke are not fully understood. This review focuses on the recent advances regarding potential molecular mechanisms of autophagy in different cell types. The focus is also on discussing the “double-edged sword” effect of autophagy in ischemic stroke and its possible underlying mechanisms. In addition, potential therapeutic strategies for ischemic stroke targeting autophagy are also reviewed.

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Section: Autophagy In Ischemic Strokementioning

confidence: 59%

Section: Figurementioning

confidence: 99%

Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

Zhang

Ding

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…However, the roles of circRNAs-regulated autophagy in acute CNS injuries, especially in ischemic stroke, were controversial. Zhou et al (2021) have found that circ0025984 protected astrocytes from OGD-induced apoptosis by suppressing autophagy through the miR-143-3p/ten-eleven translocation 1 (TET1) pathway, suggesting a detrimental role of autophagy in ischemic stroke. Interestingly, in another study conducted by Chen et al (2020c) they found that circSHOC2 inhibited OGD-induced neuronal apoptosis by promoting autophagy in ischemic brain injury, suggesting a protective role of circSHOC2 and autophagy in ischemic stroke.…”

Section: Circular Rnas Expressed In Acute Central Nervous System Inju...mentioning

confidence: 99%

“…The discrepancies may be due to the different circRNAs and cell types used in these two studies. Although the ischemic stroke model (OGD) was the same, the circRNA and cells used in Zhou et al (2021) experiments were circ0025984 and astrocytes, while the circRNA and cells used in Chen et al (2020c) experiments were circSHOC2 and neurons. In conclusion, by combination with previous studies, we though that depending on different acute CNS injury models, circRNAs and cell types, autophagy and cell death may have inhibitory, additive or even synergistic effects.…”

Section: Circular Rnas Expressed In Acute Central Nervous System Inju...mentioning

confidence: 99%

“…CircRNAs have been shown to regulate TETs in acute CNS injuries. Zhou et al (2021) suggested that overexpression of circ0025984 ameliorated ischemic stroke injury and protected astrocytes from autophagy and apoptosis through upregulation of TET1. In another study, Yu et al (2021) implied that circ0003423 alleviated ox-LDL-induced human BMECs injury via increasing the expression of TET2.…”

Section: Mechanism Of Circular Rnas In Acute Central Nervous System I...mentioning

confidence: 99%

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Circular RNA in Acute Central Nervous System Injuries: A New Target for Therapeutic Intervention

Zhang

Liu

Mao

et al. 2022

Front. Mol. Neurosci.

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Acute central nervous system (CNS) injuries, including ischemic stroke, traumatic brain injury (TBI), spinal cord injury (SCI) and subarachnoid hemorrhage (SAH), are the most common cause of death and disability around the world. As a kind of non-coding ribonucleic acids (RNAs) with endogenous and conserve, circular RNAs (circRNAs) have recently attracted great attentions due to their functions in diagnosis and treatment of many diseases. A large number of studies have suggested that circRNAs played an important role in brain development and involved in many neurological disorders, particularly in acute CNS injuries. It has been proposed that regulation of circRNAs could improve cognition function, promote angiogenesis, inhibit apoptosis, suppress inflammation, regulate autophagy and protect blood brain barrier (BBB) in acute CNS injuries via different molecules and pathways including microRNA (miRNA), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), ph1osphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT), Notch1 and ten-eleven translocation (TET). Therefore, circRNAs showed great promise as potential targets in acute CNS injuries. In this article, we present a review highlighting the roles of circRNAs in acute CNS injuries. Hence, on the basis of these properties and effects, circRNAs may be developed as therapeutic agents for acute CNS injury patients.

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Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen–glucose deprivation through modulating the miR-150-5p/MLLT1 axis

et al. 2023

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Circular RNA 0025984 Ameliorates Ischemic Stroke Injury and Protects Astrocytes Through miR-143-3p/TET1/ORP150 Pathway

Cited by 44 publications

References 54 publications

Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy

Circular RNA in Acute Central Nervous System Injuries: A New Target for Therapeutic Intervention

Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen–glucose deprivation through modulating the miR-150-5p/MLLT1 axis

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