Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis

Li, Jun; He, Xionghui; Zou, Yongping; Wang, Kaiqiong

doi:10.1007/s10620-021-07054-7

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…CircSTIL targets miR-345/AQP3 and aggravates hepatocellular carcinoma. 16 CircSTIL accelerates pancreatic cancer progression through miR-144/ STIL axis. 17 CircSTIL sponges miR-873 and miR-4426 to promote cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Previous researches have elucidated the oncogenic functions of circSTIL in cancer development. CircSTIL targets miR‐345/AQP3 and aggravates hepatocellular carcinoma 16 . CircSTIL accelerates pancreatic cancer progression through miR‐144/STIL axis 17 .…”

Section: Discussionmentioning

confidence: 99%

“…13 It has been found that some circRNAs interact with miRNAs through their miRNA response elements as competitive endogenous RNA (ceRNA), thus regulating the expression levels of other related RNAs. 14,15 Recent studies have shown that cir-cSTIL works as a ceRNA and participates in regulating the proliferation, apoptosis, migration, invasion and tumor growth in malignant cancers such as hepatocellular carcinoma, 16 pancreatic cancer, 17 and cervical cancer. 18,19 A recent circRNA expression profile sequencing study showed that circSTIL is overexpressed in CRC patients and involved in regulating cell proliferation, migration, invasion and cell cycle.…”

Section: Introductionmentioning

confidence: 99%

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CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis

Guo

et al. 2023

Environmental Toxicology

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Ferroptosis is an emerging programmed cell death and plays essential roles in tumorigenesis, including colorectal cancer (CRC). The present study intended to disclose the role of a novel oncogene circular RNA (circRNA) circSTIL in CRC phenotypes, especially ferroptosis. The expression of circSTIL was measured in CRC tissues and cells.Then, the impacts of circSTIL expression on the proliferation and ferroptosis of CRC cells were examined by loss-of-function assays in vitro. Bioinformatics, luciferase reporter assay and cell rescue assay were further performed to reveal the ceRNAassociated mechanism of circSTIL. CircSTIL was significantly upregulated in CRC. Cell proliferation was suppressed while ferroptosis was induced with the silencing of cir-cSTIL in CRC cells. Interestingly, circSTIL competed with miR-431 for solute carrier family 7 member 11 (SLC7A11) binding. Additionally, miR-431 suppression or SLC7A11 overexpression overturned circSTIL silencing-mediated cell phenotypes in CRC cells. CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis

Guo

et al. 2023

Environmental Toxicology

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“…Circular SCL-interrupting locus protein (circSTIL) upregulates aquaporin 3 (AQP3). CircSTIL (Figure 1) was reported to be up-regulated in HCC tissues and cells (50). Knockdown reduced HCC proliferation, migration, invasion and promoted HCC apoptosis in vitro, while it inhibited growth of HCC-related xenografts in nude mice after subcutaneous implantation.…”

Section: Circular Genetic Suppressor Element 1 (Circgse1) Upregulates...mentioning

confidence: 99%

“…Knockdown reduced HCC proliferation, migration, invasion and promoted HCC apoptosis in vitro, while it inhibited growth of HCC-related xenografts in nude mice after subcutaneous implantation. CircSTIL sponged miR-345-5p resulting in the up-regulation of AQP3 (50). Aquaporins (AQPs) are a family of plasma membrane receptors with six transmembrane domains which assemble as tetramers.…”

Section: Circular Genetic Suppressor Element 1 (Circgse1) Upregulates...mentioning

confidence: 99%

Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in PreclinicalIn VivoModels

WEIDLE,

NOPORA

2023

Cancer Genomics Proteomics

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Aquaporin-mediated dysregulation of cell migration in disease states

Smith

Banerjee

Moses

et al. 2023

Cell. Mol. Life Sci.

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Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis

Cited by 5 publications

References 31 publications

CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis

CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis

Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in PreclinicalIn VivoModels

Aquaporin-mediated dysregulation of cell migration in disease states

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