Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway

Zhong, Lintao; Wang, Yuanyuan; Cheng, Yu; Wang, Wen; Lu, Baoling; Zhū, Lìyǐng; Ma, Yuanyuan

doi:10.1016/j.bbrc.2018.03.221

Cited by 95 publications

(74 citation statements)

References 20 publications

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“…The aberrantly expressed circRNAs may regulate the expression of parental genes and play important roles in the pathological processes of diseases. And a considerable number of studies have indicated that circRNAs can act as "miRNA sponges" to regulate gene expression [39][40][41]. As reported by the present study, most circRNAs and mRNAs were upregulated, we speculated that circRNAs may regulate the expression of target genes by ceRNA mechanism.…”

Section: Discussionsupporting

confidence: 64%

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

et al. 2018

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Malignant pleural effusion (MPE) is a common complication of lung cancer. Accumulating evidence has suggested that circular RNAs (circRNAs) play important roles in oncogenesis and progression of cancer. However, the expression pattern of circRNAs in MPE remains largely unknown and awaits investigation. The study was designed to elucidate the potential roles of differentially expressed circRNAs in MPE. Herein, we detected a total of 1350 differentially expressed circRNAs and 1727 differentially expressed mRNAs in lung adenocarcinoma-associated malignant pleural effusion (LA-MPE) compared with tuberculous pleural effusion (TPE) by Clariom D Human Microarray. Among the top 5 up-regulated circRNAs (hsa_circ_0067705, hsa_circ_0025542, hsa_circ_0072793, hsa_-circ_0084927, and hsa_circ_0085386), four were verified significantly up-regulated in LA-MPE by qRT-PCR and hsa_circ_0085386 had an increasing trend. CircRNA-miRNA-mRNA network for the top 5 upregulated circRNAs was constructed and pathway analysis indicated that the enriched mRNA targets involved in PI3K-Akt signaling pathway, Axon guidance, Regulation of actin cytoskeleton and Rap1 signaling pathway were potentially regulated by these aberrantly expressed circRNAs. We generated specific circRNA profiles in LA-MPE for the first time. And analysis of circRNA regulatory network could provide evidence that circRNAs are important in MPE development because they participate in cancer-related pathways by sequestering miRNAs. Our findings suggested that aberrantly expressed circRNAs may be involved in the development of LA-MPE. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 64%

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

et al. 2018

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“…Interestingly, circARSP91 inhibits HCC tumor growth via the AR/ADAR1/circARSP91 axis . As a tumor suppressor, circC3P1 acts as a sponge of miR‐4641, promotes PCK1 expression, and inhibits migration and invasion of HCC cells in vitro and in vivo …”

Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

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internal ribosome entry site; LARP4, La-related protein 4; LATS1, large tumor suppressor kinase 1; lncRNAs, long noncoding RNAs; MIBC, muscle invasive bladder cancer; miRNA, microRNA; ncRNAs, noncoding RNAs; NF1, neurofibromin 1; Notch1, notch homolog 1; NSCLC, non-small cell lung cancer; OS, overall survival; PCK1, phosphoenolpyruvate carboxykinase 1; PDAC, pancreatic ductal adenocarcinoma; RBP, RNA-binding protein; RCAN1, regulation of Down syndrome critical region gene 1; sncRNAs, short noncoding RNAs; TIMP3, metalloproteinase inhibitor 3; USP28, ubiquitin-specific peptidase 28; YBX1, Y box binding protein 1. AbstractCircular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circ-ADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_ circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive cir-cRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs. K E Y W O R D Sbiogenesis, cancer, circular RNA, mechanism, therapeutic target | INTRODUC TI ONThose RNAs that do not encode proteins are called ncRNAs. 1 Regulatory ncRNAs are divided into lncRNAs and sncRNAs. LncRNAs can be linear or circular. 2 Circular RNAs were first discovered in 1976. 3 Since then, a variety of circRNAs have been discovered. 4,5 CircRNAs are more resistant to exonuclease and are more stable than other lncRNAs. 3,6 They exist in exosomes and plasma. 6,7 Li et al identified more than 1000 circRNAs in human serum exosomes. 6 Li et al found 343 differentially How to cite this article:

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“…cSMARCA5 overexpression facilitated apoptosis and repressed the invasion, migration, and proliferation of HCC cells, and this circRNA upregulated TIMP3 by adsorbing miR-181b-5p and miR-17-3p [70,71]. Furthermore, circMTO1 [72], circADAMTS14 [73], the circRNA SMAD2 [74], and circC3P1 (miR-4641/PCK1) [75] could serve as miRNA sponges to restrain HCC cell tumorigenic behaviours. Moreover, overexpression of both circZKSCAN1 and ZKSCAN1 mRNA repressed the invasion, migration, and proliferation of HCC cells; however, the mechanism of action of circZKSCAN1 was not related to its parental gene ZKSCAN1 (a zinc finger family gene).…”

Section: Circrnas That Act As Tumour Suppressors In Hccmentioning

confidence: 98%

“…To provide the foundation for research on circRNA function, the subcellular location (nucleus or cytoplasm) of circRNAs first need to be analysed based on efficient nuclear/cytoplasmic RNA separation [44] and fluorescence in situ hybridisation (FISH) [48,52]. Then, gain-of-function (GOF) and loss-of-function (LOF) are employed to study circRNA functions in digestive system cancer cell lines and xenograft nude mouse models [46,67,72,75]. Human circRNA can be synthesised and cloned into the overexpression vector pcDNA3.1 [45].…”

Section: Function and Mechanism Of Circrnamentioning

confidence: 99%

The Regulatory Functions of Circular RNAs in Digestive System Cancers

Yuan

Yuán

et al. 2020

Cancers

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Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer.

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Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway

Cited by 95 publications

References 20 publications

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

The Regulatory Functions of Circular RNAs in Digestive System Cancers

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