Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Garikipati, Venkata Naga Srikanth; Verma, Suresh; Cheng, Zhongjian; Liang, Dongming; Truongcao, May; Cimini, Maria; Yue, Yujia; Huang, Grace; Wang, Chunlin; Benedict, Cindy; Tang, Yan; Mallaredy, Vandana; Ibetti, Jessica; Grisanti, Laurel A.; Schumacher, Sarah M.; Gao, Erhe; Rajan, Sudarsan; Wilusz, Jeremy E.; Goukassian, David A.; Houser, Steven R.; Koch, Walter J.

doi:10.1038/s41467-019-11777-7

Cited by 328 publications

(248 citation statements)

References 62 publications

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“…Previous studies have revealed that circRNAs play important roles in the regulation of multiple diseases, especially cancers (39)(40)(41)(42). Aberrant expression of circRNAs was also correlated with progression, drug resistance and prognosis of cancers (21).…”

Section: Discussionmentioning

confidence: 99%

EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

Cheng

Luo

Zhan³

et al. 2020

Int J Mol Med

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Substantial evidence indicates that circular RNAs (circRNAs) play vital roles in several diseases, especially in cancer development. However, the functions of circRNAs in breast cancer metastasis remain to be investigated. This study aimed to identify the key circRNAs involved in epithelial mesenchymal transition (EMT) of breast cancer and evaluated their molecular function and roles in pathways that may be associated with tumor metastasis. An EMT model was constructed by treating breast cancer cells McF-7 and MdA-MB-231 with transforming growth factor-β1. High-throughput RNA sequencing was used to identify the differentially expressed circRNAs in EMT and blank groups of two cells, and reverse transcription-quantitative PcR was used to validate the expression of circScYL2 in human breast cancer tissues and cells. The effects of circScYL2 on breast cancer cells were explored by transfecting with plasmids and the biological roles were assessed using transwell assays. EMT groups of breast cancer cells exhibited the characteristics of mesenchymal cells. Furthermore, the present study found that 7 circRNAs were significantly upregulated in both the MCF-7 EMT and MdA-MB-231 EMT groups, while 16 circRNAs were significantly downregulated. The current study identified that circScYL2 was downregulated in breast cancer tissues and cell lines, and that circScYL2 overexpression inhibited cell migration and invasion. This study provides expression profiles of circRNAs in EMT groups of breast cancer cells. circScYL2, which is downregulated in breast cancer tissues and cells, may play an important role in breast cancer EMT progression. EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

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Section: Discussionmentioning

confidence: 99%

EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

Cheng

Luo

Zhan³

et al. 2020

Int J Mol Med

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“…CircFndc3b could function through interacting with RBP-FUS which regulates the expression and the signaling pathway of vascular endothelial growth factor-A (VEGF-A). The overexpression of circFndc3b in post-MI mouse hearts could decrease cardiomyocyte apoptosis and fibrosis, enhance neovascularization, reduce infarct size and attenuate left ventricular dysfunction after MI ( Garikipati et al, 2019 ). CircTtc3 was reported to be significantly upregulated in rats with MI ( Cai et al, 2019 ).…”

Section: Circrnas and Cardiovascular Diseasesmentioning

confidence: 99%

Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease

Zhang

Wang

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular disease (CVD) causes high morbidity and mortality worldwide. Accumulating research has indicated the possible roles played by circular RNAs (circRNAs) in the pathogenesis of CVD. CircRNAs are non-coding RNAs with covalently closed loop structures. CircRNAs can function by acting as miRNA sponges, RNA binding protein sponges, mRNA transcriptional regulators and templates for protein translation. The specific characteristics of circRNAs such as high stability, abundant distribution, and tissue- and developmental stage-specific expression make them potential biomarkers for the diagnosis and prognosis of CVD. In this paper, we systematically summarized the current knowledge regarding the biogenesis, biological properties and the action mechanisms of circRNAs, elucidated the roles played by circRNAs in the pathogenesis of CVD, and explored the diagnostic potential of circRNAs in CVD. With in-depth studies, an increasing number of molecular mechanisms underlying the participation of circRNAs in CVD may be elucidated, and the application of circRNAs in the clinical diagnosis and prevention of CVD may eventually be realized.

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“…Circular RNA (circRNA) are a class of singlestranded RNA that are covalently closed by linking the 3 0 and 5 0 ends, and many of them have been recognized to be involved in various human diseases as gene regulators [8]. CircFNDC3B is a circRNA that is formed by back-splicing exons 5 and 6 in the FNDC3B gene and has recently been implicated in gastric cancer [9], cardiovascular disease [10], bladder cancer [11] and renal carcinoma [12] by modulation of specific signaling pathways. However, the expression level of circFNDC3B and its underlying molecular mechanisms in CRC have never been reported.…”

Section: Introductionmentioning

confidence: 99%

CircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression

Zeng

Liu

et al. 2020

Molecular Oncology

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Circular RNA (circRNA) are single-stranded RNA with covalently closed 3 0 and 5 0 ends, with many recognized to be involved in human diseases as gene regulators, typically by interacting with other RNA. CircFNDC3B is a circRNA formed by back-splicing of exons 5 and 6 of the FNDC3B gene. CircFNDC3B was recently implicated in renal carcinoma, gastric and bladder cancer. However, the expression levels of circFNDC3B and its role in colorectal cancer (CRC) remain unclear. Expression of circFNDC3B and TIMP3 levels in CRC tissues and cell lines were found to be low, whereas microRNA (miR)-937-5p expression was high in CRC. Micro-RNA-937-5p downregulated TIMP3, thereby promoting tumor cell proliferation, invasion, migration and angiogenesis. Moreover, CircFNDC3B was shown to bind to miR-937-5p. CircFNDC3B and circFNDC3B-enriched exosomes inhibited tumorigenic, metastatic and angiogenic properties of CRC, and miR-937-5p overexpression or TIMP3 knockdown could reverse these effects. In vivo CRC tumor growth, angiogenesis and liver metastasis were suppressed by circFNDC3B overexpression, circFNDC3Benriched exosomes or miR-937-5p knockdown. In conclusion, our work reports a tumor-suppressing role for the circFNDC3B-miR-97-5p-TIMP3 pathway and suggests that circFNDC3B-enriched exosomes can inhibit angiogenesis and CRC progression.

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Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Cited by 328 publications

References 62 publications

EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis

Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease

CircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression

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