Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation

Chen, Qi; Mang, Ge; Wu, Jian; Park, Sun; Li, Tingting; Zhang, Hanlu; Wang, Naixin; Tong, Zhonghua; Wang, Weiwei; Yang, Zheng; Tian, Jing; E, Mingyan; Zhang, Maomao; Yu, Bo

doi:10.1016/j.ymthe.2020.07.001

Cited by 42 publications

(34 citation statements)

References 58 publications

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“…Recent evidence has shown that circular RNA (circRNA), which are endogenously expressed and produced through back-splicing, can regulate gene expression and molecular function. [15][16][17][18][19] We and the Yu B group previously showed that circRNA participates in DC development, and circRNA expression profiles are significantly different between mature DCs (mDCs) and immature DCs (imDCs). 13,16 However, the role of circRNA in the regulation of DC development and function is unknown.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19] We and the Yu B group previously showed that circRNA participates in DC development, and circRNA expression profiles are significantly different between mature DCs (mDCs) and immature DCs (imDCs). 13,16 However, the role of circRNA in the regulation of DC development and function is unknown. Our unpublished microarray data have shown that circular RNA FSCN1 (circFSCN1) is very abundant in DCs and is one of the most significantly upregulated (~2 fold) circRNAs in mDCs.…”

Section: Introductionmentioning

confidence: 99%

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Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation

Wang

Zhou

et al. 2021

The Journal of Heart and Lung Transplantation

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation

Wang

Zhou

et al. 2021

The Journal of Heart and Lung Transplantation

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“…Li et al Indicated hsa_circ_0002483, through targeting miR-182-5p, can enhance sensitivity of lung cancer for the taxol and suppressed lung cancer progression [ 12 ]. Chen et al showed that circSnx5 controlled the immunogenicity of dendritic cells via the miR-544/SOCS1 pathway [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis

Chen

et al. 2020

Aging

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Circular RNAs (circRNAs) are newly-discovered endogenous non-coding RNAs that have vital functions in regulating gene expression in tumorigenesis. Nonetheless, the function of circRNAs in acute myeloid leukemia (AML) are not yet clarified. In this analysis, hsa_circ_0079480, a novel circRNA, has been identified as being highly expressed in AML. Loss-of-function assays showed that reduction of hsa_circ_0079480 decreased the growth and stimulated apoptosis of AML cells in vitro . Furthermore, miR-654-3p was sponged by hsa_circ_0079480, and hepatoma-derived growth factor (HDGF) was targeted by miR-654-3p with respect to the fundamental mechanism. Moreover, the influence on growth and apoptosis of AML cells stimulated by hsa_circ_0079480 inhibition can be rescued by miR-654-3p inhibitor or HDGF overexpression. In summary, hsa_circ_0079480 is highly expressed in AML and drives by tumor progression via regulation of hsa_circ_0079480/miR-654-3p/HDGF axis, indicating that hsa_circ_0079480 may function as a new treatment target for AML therapy.

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“…Yang et al veri ed the RNA expression level of circPTK2 in colon cancer and normal colon tissues, and veri ed that the expression content of circPTK2 is related to the clinical stage of colon cancer patients, and in vitro and PDTX models, veri ed that the increase in circPTK2 expression can be Promote the metastasis of colon cancer [19]. The results of Chen et al con rmed that circSnx5 could act as a miR-544 sponge to reduce Suppressors of cytokine signaling 1 (SOCS1) target inhibition and inhibit the nuclear transport of PU.1, and regulate dendritic cell (DC) activation and function [20].…”

Section: Discussionmentioning

confidence: 99%

Construction of circRNA-based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma

Deng

Chen

Dong

et al. 2020

Preprint

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Background: Circular RNAs (circRNAs) are now under hot discussion as novel promising bio-markers for patients with hepatocellular carcinoma. The purpose of our study is to identify several competing endogenous RNAs (ceRNAs) networks related to the prognosis and progression of hepatocellular carcinoma, and to further investigate the mechanism of their influence on tumor progression.Methods: First, we obtained gene expression data related to liver cancer from the TCGA database (http://www.portal.gdc.cancer.gov/), including miRNA-seq, RNA-seq and clinical information. A co-expression network was constructed through the WGCNA software package in R software, with the purpose of identifying important microRNAs (miRNAs) and messenger RNAs (mRNAs) related to liver cancer. The DEmRNAs in the key module were analyzed with DAVID (https://david.ncifcrf.gov/summary.jsp) to perform functional enrichment analysis including Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO). The data of miRNA expression and clinical information downloaded from TCGA was utilized for survival analysis to detach the prognostic value of the DEmiRNAs of the key module. Results：201 DEmiRNAs and 3783 DEmRNAs were finally identified through differential expression analysis. The co-expression networks of DEmiRNA and DEmRNA were constructed by using WGCNA. Further analysis confirmed 4 miRNAs in the most significant module (blue module) were associated with the OS of patients with liver cancer, including hsa-miR-92b-3p, hsa-miR-122-3p, hsa-miR-139-5p and hsa-miR-7850-5p. DAVID was used for functional enrichment analysis of 286 co-expressed mRNAs. The Gene Ontology (GO) analysis results showed that the top enriched GO terms were oxidation-reduction process, extracellular exosome and iron ion binding. In Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the top 3 enriched terms included metabolic pathways, fatty acid degradation and valine, leucine and isoleucine degradation. In addition, we corssed the miRNA-mRNA interactions prediction results with the differentially expressed and prognostic mRNAs, and found that hsa-miR-92b-3p can be related to cytoplasmic polyadenylation element binding protein 3 (CPEB3) and Acyl-CoA Dehydrogenase Long Chain (ACADL). By overlapping the data of predicted circRNAs by circBank and differentially expressed circRNAs of GSE94508, we screened has_circ_0077210 as the upstream regulatory molecule of hsa-miR-92b-3p. Hsa_circ_0077210/hsa-miR-92b-3p/CPEB3&ACADL were validated in hepatic cell carcinoma (HCC) tissues and human protein atlas (HPA) database.Conclusion: Our research provides a mechanistic elucidation of the unknown ceRNA regulatory network in HCC. Hsa_circ_0077210 might serve as an important biomarker to promote the occurrence and development of HCC.

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Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation

Cited by 42 publications

References 58 publications

Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation

Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation

Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis

Construction of circRNA-based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma

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