Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C

Yang, Binlin; Liu, Guoqiang; Li, Ping; Li, Xiaohui

doi:10.18632/aging.203827

Cited by 20 publications

(8 citation statements)

References 29 publications

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“…25 Circ CUL2 served as an antitumor factor to facilitate PPP6C expression and colorectal cancer progression via absorbing miR-208a-3p. 26 Moreover, the roles of circRNAs in the HCC process have been revealed. 27 For instance, hsa_ circ_0032683 suppressed HCC cell growth and boosted HCC cell apoptosis via sponging miR-338-5p.…”

Section: Discussionmentioning

confidence: 99%

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Depletion of circ_0088046 suppressed cell growth and motility of hepatocellular carcinoma via circ_0088046‐miR‐1299‐RTKN2 ceRNA pathway

Zhang

Guan

et al. 2023

Journal of Viral Hepatitis

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Circular RNAs (circRNAs) have been verified to be important modulators and therapeutic targets of human hepatocellular carcinoma (HCC). This study aims to explore the role and mechanism of circ_0088046 in HCC progression. Quantitative real‐time polymerase chain reaction (qRT‐PCR), western blot and immunohistochemistry assays were used to detect the mRNA and protein expression of circ_0088046, miR‐1299, Rhotekin 2 (RTKN2), Bax, Bcl‐2, E‐cadherin and Ki‐67. Cell proliferation was investigated by 5‐Ethynyl‐2′‐deoxyuridine (EdU) assay and cell colony formation assay. Cell apoptosis rate was measured by flow cytometry. Transwell migration and invasion assays were adopted to assess cell migration and invasion. The molecular target relationship between miR‐1299 and circ_0088046 or RTKN2 were analysed by dual‐luciferase reporter assay and RNA immunoprecipitation assay. An animal experiment was conducted to demonstrate the effect of circ_0088046 on tumour formation in vivo. High levels of circ_0088046 and RTKN2, and low levels of miR‐1299 were displayed in HCC tissues and cells. Circ_0088046 absence repressed cell proliferation, migration and invasion, but boosted apoptosis of HCC cells. MiR‐1299 was a target of circ_0088046 and miR‐1299 inhibitor restored circ_0088046 silencing‐mediated inhibitory impacts on HCC cell malignancy. MiR‐1299 could directly target RTKN2, and overexpressed RTKN2 rescued the suppressive effects caused by miR‐1299 mimic. In addition, circ_0088046 silencing constrained tumour formation in vivo. Circ_0088046 contributed to HCC cell malignancy via modulating the miR‐1299/RTKN2 axis.

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Section: Discussionmentioning

confidence: 99%

“…Circ_0000658 acted as a tumour‐promoting factor in bladder cancer via regulating the miR‐498/HMGA2 axis 25 . Circ CUL2 served as an antitumor factor to facilitate PPP6C expression and colorectal cancer progression via absorbing miR‐208a‐3p 26 . Moreover, the roles of circRNAs in the HCC process have been revealed 27 .…”

Section: Discussionmentioning

confidence: 99%

Depletion of circ_0088046 suppressed cell growth and motility of hepatocellular carcinoma via circ_0088046‐miR‐1299‐RTKN2 ceRNA pathway

Zhang

Guan

et al. 2023

Journal of Viral Hepatitis

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“…Importantly, circular RNAs (circRNAs) are a special class of ncRNAs that often function as competing endogenous RNAs (ceRNAs) for miRNAs, which implied an emerging strategy in cancer therapy. For instance, circCUL2 acts as a sponge for miR-208a-3p to inhibit tumor proliferation via upregulating protein phosphatase 6 catalytic subunit (PPP6C), which induces autophagy in SW480 and SW620 human CRC cells and the SW480 xenograft model ( 52 ). Similarly, circHIPK3 acts as a sponge for miR-637 to upregulate STAT3, activating downstream Bcl-2 to suppress beclin1 to inhibit autophagy in vitro and in vivo ( 53 ) ( Figure 2C ).…”

Section: Therapeutic Strategies Targeting Autophagy For Crc Therapymentioning

confidence: 99%

Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies

Qiang

Liu²,

Wang³

et al. 2022

Front. Oncol.

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Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies.

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“…Many circular RNAs have been discovered to be biomarkers that impact the onset and growth of malignancies in recent years, attracting a lot of attention. They have been identified in lung cancer ( 6 ), hepatocellular carcinoma ( 7 ), gastric cancer ( 8 ), colorectal cancer ( 9 ), and so on. However, the molecular mechanisms and early diagnosis of cancer are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Zhang

et al. 2022

Front. Oncol.

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Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.

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Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C

Cited by 20 publications

References 29 publications

Depletion of circ_0088046 suppressed cell growth and motility of hepatocellular carcinoma via circ_0088046‐miR‐1299‐RTKN2 ceRNA pathway

Depletion of circ_0088046 suppressed cell growth and motility of hepatocellular carcinoma via circ_0088046‐miR‐1299‐RTKN2 ceRNA pathway

Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies

Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

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