Circular RNA involvement in aging: An emerging player with great potential

Cai, Hong-Cai; Li, Yamin; Niringiyumukiza, Jean Damascene; Su, Ping; Xiang, Wenpei

doi:10.1016/j.mad.2018.11.002

Cited by 105 publications

(70 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several circRNAs show clear evolutionary conservation or strict regulation function, implying that they are of functional importance. [14][15][16] The aberrant expression of circRNA has been found in a wide variety of tumors, including GM. [10][11][12][13] For example, Lei et al 17 revealed that hsa_circ_0076248 could promote GM tumorigenesis through sponging miR-181a and regulate SIRT1 expression.…”

Section: Circ-pitx1 Facilitates Cell Progression By Affecting Mir-5mentioning

confidence: 99%

Elevation of circ‐PITX1 upregulates interleukin 17 receptor D expression via sponging miR‐518a‐5p and facilitates cell progression in glioma

Zhan

Zhuang

Yang

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

Glioma (GM) is one of the major global health problems across the world. Circular RNAs (circRNAs) have been increasingly identified and characterized in almost every aspect of biology, especially in cancer biology. This study desires to investigate the mechanism of circ‐PITX1 on regulating GM development. Quantitative reverse‐transcription polymerase chain reaction was carried out to measure the expression of circ‐PITX1, which was upregulated in matched cancerous tissues and adjacent noncancerous tissues from 52 patients and four cell lines of GM. Fisher's exact indicated the upregulation of circ‐PITX1 was associated with patients' tumor size and World Health Organization grade. Gain and loss‐of‐function assays demonstrated that circ‐PITX1 could facilitate the growth, migration, and invasion and inhibit cell apoptosis in GM cell lines. What's more, circ‐PITX1 sponges miR‐518a‐5p to release its repression on 3′‐untranslated region (3′UTR) of interleukin 17 receptor D (IL17RD) messenger RNA to exert its oncogenic functions in GM cells proved by dual‐luciferase reporter and rescue assays. Taken together, circ‐PITX1 may play a critical role in GM and may be used as a therapeutic target for GM.

show abstract

Section: Circ-pitx1 Facilitates Cell Progression By Affecting Mir-5mentioning

confidence: 99%

Elevation of circ‐PITX1 upregulates interleukin 17 receptor D expression via sponging miR‐518a‐5p and facilitates cell progression in glioma

Zhan

Zhuang

Yang

et al. 2019

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…In this study, circ_RPL23A was selected as a down-regulated gene through microarray analysis and its differential expression was also proved in CCRCC tissues and cells. As the result of close-loop structures, circRNAs are highly conserved and stable compared to the linear RNAs [26]. We found that circ_RPL23A was not easily affected by Actinomycin D and RNase treatment, testifying the identi cation of circ_RPL23A as a circRNA.…”

Section: Discussionmentioning

confidence: 71%

Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2

Cheng

Cao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Clear cell renal cell carcinoma (CCRCC) is a prevalent urological carcinoma with high metastatic risk. Circular RNAs (circRNAs) have been identified as effective diagnostic and therapeutic biomarkers for CCRCC. This research aims to disclose the involvement of circRNA ribosomal protein L23a (circ_RPL23A) in CCRCC, and how it regulates carcinogenesis. Methods We performed quantitative real-time polymerase chain reaction (qRT-PCR) to examine circ_RPL23A, microRNA-1233 (miR-1233) and acetyl-coenzyme A acetyltransferase 2 (ACAT2). Cellular behavior detection included cell cycle, proliferation, apoptosis and metastasis, which were severally analyzed using propidium iodide (PI)-flow cytometry, 3-(4, 5-dimethylthiazol-2-y1)-2, 5-diphenyl tetrazolium bromide (MTT), Annexin V/PI-flow cytometry and transwell migration/invasion assays. ACAT2 and related proteins of cell cycle, epithelial-mesenchymal transition (EMT) were measured via western blot. Target relationship was analyzed via dual-luciferase reporter assay. A xenograft model was used to study circ_RPL23A action in mice. Results Both in CCRCC tissues and cells, circ_RPL23A had a down-regulated tendency. Explicitly, circ_RPL23A overexpression inhibited cell cycle, proliferation and metastasis but enhanced apoptosis of CCRCC cells, whereas these effects of circ_RPL23A were dependent on the suppression of its target miR-1233. Besides, miR-1233 could target ACAT2 and circ_RPL23A regulated ACAT2 by sponging miR-1233. Also importantly, miR-1233 was a pro-cancer gene in CCRCC via targeting ACAT2. CCRCC tumor growth was also decreased in vivo by circ_RPL23A through miR-1233/ACAT2 axis. Conclusion Altogether, the circ_RPL23A/miR-1233/ACAT2 axis in this report provides an in-depth cognition for CCRCC pathogenesis and circ_RPL23A may has pivotal value in diagnosing and treating CCRCC.

show abstract

“…Ils pourraient avoir un rôle crucial dans la régulation des gènes responsables de la maladie d'Alzheimer, par leur fonction d'éponge à miARN pour certains, ou de protéines, en étant traduits pour d'autres. Les circARN apparaissent de plus en plus comme des acteurs-clés du processus de vieillissement, non seulement du système nerveux, mais de tissus comme le muscle et la peau [31]. Il a même été proposé que l'accumulation des circARN soit un marqueur du vieillissement, si tant est que l'on considère ce processus comme une maladie [32].…”

Section: Les Circarn Une Nouvelle Classe D'arn Messagersunclassified

L’ARN circulaire nous joue-t-il des tours ?

et al. 2020

View full text Add to dashboard Cite

L’ARN n’a pas dit son dernier mot… avec l’émergence des ARN circulaires (circARN). Quatorze pour cent des gènes humains produisent en effet des circARN par un mécanisme d’épissage alternatif : le rétro-épissage. Chez l’homme, plus de 100 000 circARN différents ont ainsi été répertoriés. Dans le noyau, ils régulent la transcription ou l’épissage des ARNm, alors que, dans le cytoplasme, ils séquestrent des miARN et des protéines, ou sont traduits par un mécanisme d’initiation interne de la traduction. Ces circARN constituent en fait un outil biotechnologique performant car leur traduction est très stable dans le temps, et les circARN exogènes induisent moins de réponses immunitaires que les ARNm linéaires. Dans cette revue, nous discuterons, après les avoir décrits, du rôle des circARN dans différents processus pathologiques et de leur utilisation en biotechnologie.

show abstract

Circular RNA involvement in aging: An emerging player with great potential

Cited by 105 publications

References 101 publications

Elevation of circ‐PITX1 upregulates interleukin 17 receptor D expression via sponging miR‐518a‐5p and facilitates cell progression in glioma

Elevation of circ‐PITX1 upregulates interleukin 17 receptor D expression via sponging miR‐518a‐5p and facilitates cell progression in glioma

Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2

L’ARN circulaire nous joue-t-il des tours ?

Contact Info

Product

Resources

About