Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis

Zou, Chen; Li, Xia; Lv, Xiaoyang; Wu, Si-Pei; Song, Jing; Tang, Zhe; Luo, Hailing; Wei, Haigang; Ai, Yilong

doi:10.1080/21655979.2021.1997699

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…The genes with the highest degree in the Co-DEmiRNA-Gene network include ZNF460 , FBN1 , CDK6 , BTG2, and CBX6 , which may be the essential hub genes/mediators between OSCC and PD. ZNF460 (zinc finger protein 460) is involved in the regulation of multiple cancer processes by JAK2/STAT3 pathway [ 39 ], and its high expression is associated with the proliferation, invasion, and metastasis of colorectal cancer and oral cancer [ 39 , 40 ]. FBN1 (fibrinin-1) is a common extracellular matrix encoding gene [ 41 ], and inactivation will affect the integrity of tissues (aortic wall, periodontal membrane, oral epithelial barrier, etc.).…”

Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

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Background Oral squamous cell carcinoma (OSCC) is one of the malignant tumors with a poor prognosis. Periodontitis (PD is considered a high-risk factor for OSCC, but the genetic mechanism is rarely studied. This study aims to link OSCC and PD by identifying common differentially expressed miRNAs (Co-DEmiRNAs), their related genes (Hub genes), transcription factors (TFs), signaling pathways, enrichment functions, and compounds, and searching for genetic commonalities. Methods The miRNAs expression datasets of OSCC and PD were searched from the GEO database. The miRNA and related crosstalk mechanism between OSCC and PD was obtained through a series of analyses. Results hsa-mir-497, hsa-mir-224, hsa-mir-210, hsa-mir-29c, hsa-mir-486-5p, and hsa-mir-31are the top miRNA nodes in Co-DEmiRNA-Target networks. The most significant candidate miRNA dysregulation genes are ZNF460, FBN1, CDK6, BTG2, and CBX6, while the most important dysregulation TF includes HIF1A, TP53, E2F1, MYCN, and JUN. 5-fluorouracil, Ginsenoside, Rh2, and Formaldehyde are the most correlated compounds. Enrichment analysis revealed cancer-related pathways and so on. Conclusions The comprehensive analysis reveals the interacting genetic and molecular mechanism between OSCC and PD, linking both and providing a foundation for future basic and clinical research.

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Section: Discussionmentioning

confidence: 99%

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Wen

et al. 2023

BMC Oral Health

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“…Some emerging circRNAs acted crucial characters in OSCC progression. For instance, circRNA mitochondrial translation optimization 1 homologue promoted OSCC cell proliferation, migration, and invasion in vitro via miR-320a/alpha thalassemia/mental retardation, X-linked (ATRX) axis [ 31 ]. Circ_0005320 silencing impeded OSCC growth in vivo and in vitro by sponging miR-486-3p and miR-637 [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis

Long

Zhu

2022

Bioengineered

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Oral squamous cell carcinoma (OSCC) is a common cancer with high recurrence, metastasis rates and poor prognosis. Circular RNAs (circRNAs) take part in regulating OSCC. Herein, we examined the role of circ_0008068 in OSCC. The circ_0008068, Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) mRNA, microRNA-153-3p (miR-153-3p) and acylgycerol kinase (AGK) contents were indicated by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Moreover, in vitro and in vivo assays were conducted to scrutinize the effects of circ_0008068 on OSCC. Additionally, the contact between miR-153-3p and circ_0008068 or AGK was assessed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Thereafter, we found that the appearance of circ_0008068 and AGK was increased, and miR-153-3p content was diminished in OSCC. Circ_0008068 lack subdued cell proliferation, migration, invasion, tube formation and glycolysis metabolism, but stimulated cell apoptosis in OSCC. In addition, circ_0008068 bound to miR-153-3p to modulate the expression of its target AGK. Besides, miR-153-3p was validated to act as a tumor suppressor in OSCC tumorigenesis by suppressing AGK. Additionally, circ_0008068 knockdown also attenuated tumor growth in nude mice. In all, circ_0008068 expedited the growth of OSCC by miR-153-3p/AGK axis. Abbreviations: OSCC: Oral squamous cell carcinoma; AGK: Acylgycerol kinase; CircRNA: Circular RNA; KATNAL1: Katanin p60 ATPase-containing subunit A-like 1; qRT-PCR: Quantitative real-time polymerase chain reaction; miRNAs/miRs: MicroRNAs; RIP: RNA immunoprecipitation; 3′UTR3’: -untranslated region; HK2: Hexokinase 2; LDHA Lactate dehydrogenase A; IHC: Immunohistochemistry; CCK8: Cell counting kit-8; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase

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“…The tumor-promoting effect of circMTO1 is also documented in oral squamous cell carcinoma. 32 The circMTO1 knockdown represses chemoresistance, migration, and invasion of CCCs. 33 Our study initially analyzed the diagnostic value of circMTO1 for CC.…”

Section: Discussionmentioning

confidence: 99%

High Expression of Circular RNA–Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer

Cheng

Changmei

Zhenrong

2022

J Low Genit Tract Dis

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Objective Persistence of high-risk human papillomavirus (HR-HPV) infection is a paramount determinant in cervical cancer (CC) development. Circular RNAs have the potential to be promising biomarkers for various cancers. This study explored circular RNA–mitochondrial tRNA translation optimization 1 (circMTO1) expression in the serum of CC patients and its clinical value in diagnosing CC and predicting HR-HPV infection. Materials and Methods In total, 125 CC patients (including 78 cases with HR-HPV) were enrolled, with another 76 healthy people as controls. Serum circMTO1 and miR-199a expressions were detected by reverse transcription–quantitative polymerase chain reaction, and the diagnostic efficacy of circMTO1 for CC and HR-HPV infection was analyzed by the receiver operating characteristic curve. According to the median of serum circMTO1 expression, CC patients were assigned into circMTO1 low/high expression groups to analyze the correlation between circMTO1 and clinical parameters using the Fisher and χ 2 tests. Independent association of circMTO1 with HR-HPV infection in CC was evaluated via logistics multivariate regression analysis. Targeted relationship between miR-199a and circMTO1 was predicted by Starbase Web site and validated via dual-luciferase assay, with their correlation further assessed by Pearson analysis. Results Serum circMTO1 was increased in CC patients and prominently elevated in HR-HPV–positive CC patients, with a level greater than 1.485 assisting CC diagnosis and a level greater than 2.480 assisting HR-HPV–positive diagnosis. The circMTO1 was interrelated to clinical stage, tumor differentiation, lymph node metastasis, invasion depth, and independently linked with HR-HPV infection in CC. Serum miR-199a was downregulated in HR-HPV–positive CC patients and inversely correlated with circMTO1. Conclusions Serum circMTO1 is upregulated in HR-HPV–positive CC patients and has a diagnostic value for HR-HPV infection in CC.

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Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis

Cited by 17 publications

References 32 publications

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Network analysis reveals miRNA crosstalk between periodontitis and oral squamous cell carcinoma

Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis

High Expression of Circular RNA–Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer

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