Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer

Chen, Jie; Li, Yan; Zheng, Qiuling; Bao, Chunyang; He, Jian; Chen, Bin; Lyu, Dongbin; Zheng, Biqiang; Xu, Yu; Long, Ziwen; Zhou, Ye; Zhu, Huiyan; Wang, Yanong; He, Xianghuo; Shi, Yingqiang; Huang, Shenglin

doi:10.1016/j.canlet.2016.12.006

Cited by 612 publications

(570 citation statements)

References 27 publications

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“…A total of 2585 participants were included with a maximum sample size of 593 and a minimum sample size of 30. Among the 15 articles, the digestive system malignancies assessed in these studies included esophageal carcinoma (2 articles) [39, 44], gastric cancer (6 articles) [22, 33, 38, 40-42], colorectal cancer (2 articles) [20, 37], hepatocellular carcinoma (2 articles) [21, 34], pancreatic cancer (3 articles) [35, 36, 43]. Among the eligible articles, one came from Japan [20], one came from Portugal [36] and the rest of 13 articles were came from China [21-22, 33-35, 37-44].…”

Section: Resultsmentioning

confidence: 99%

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Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers

Liu

Dong²,

Huang

2017

Cell Physiol Biochem

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Background/Aims: Many studies have reported that PVT1 played important roles in diverse cancer types. But the systematic analysis of PVT1 in gastrointestinal cancers has not been inspected. Thus, we aimed to investigate clinical value of the long noncoding RNA PVT1 (lncRNA) expression in digestive system cancers. Methods: Eligible studies were collected from a number of databases (PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure and Wanfang database). Pooled hazard ratio (HR) or odds ratio (OR) with 95 % confidence interval (95 % Cl) were applied to assess the clinical significance of PVT1. Results: Data from 15 articles were included with a total of 2585 patients. Elevated PVT1 expression were significantly related to poor overall survival (OS) [HR = 1.86, 95% CI (1.44, 2.28); p<0. 0001] in digestive system cancers. The same association was also observed between PVT1 expression with outcomes, including disease free survival (DFS), disease specific survival (DSS) and relapse free survival (RFS). The lncRNA PVT1 could also be predicative for some clinicopathological features. Conclusions: This meta-analysis revealed that PVT1 may serve as a prognostic predictor and pathological biomarker in digestive system cancers.

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Section: Resultsmentioning

confidence: 99%

“…A total of 10 studies reported the OS of 1179 patients according to PVT1 expression levels in tissues [20, 21, 33-38, 42, 44]. Since no significant heterogeneity was observed among studies (I 2 = 0.0%, P h = 0.752), the fixed-effects model was applied to calculate the pooled HR with corresponding 95% CI.…”

Section: Resultsmentioning

confidence: 99%

Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers

Liu

Dong²,

Huang

2017

Cell Physiol Biochem

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“…A meta-analysis by Liu et al also suggested that the up-regulation of PVT1 predicted lymph node metastasis and a worse OS in cancer patients, although the association between PVT1 and other clinicopathological parameters was not discussed [15]_ENREF_15. In addition, other publications since 2015 have continued to investigate the association between PVT1 expression and the prognosis of cancer patients [13, 14, 26-35]. To reach a more convincing conclusion and explore the potential mechanism of action of PVT1 in tumors, we performed the current study by merging the results of published studies and TCGA survival data and conducting GO and KEGG analyses.…”

Section: Discussionmentioning

confidence: 99%

“…However, rectum adenocarcinoma (READ), skin cutaneous melanoma (SKCM), and stomach adenocarcinoma (SKAD) in the TCGA dataset were correlated with a good prognosis although the results were not statistically significant; their corresponding HR values were 0.786 (95%CI: 0.379-1.629, P= 0.517) ‚ 0.92 (95%CI: 0.742-1.141, P= 0.449) and 0.912 (95%CI: 0.702-1.183, P= 0.486) , respectively. We reviewed the relevant studies and found that the high PVT1 level was associated with worse outcomes in gastric cancer and colorectal cancer [22, 26, 30, 33, 36] and that there was no corresponding report for melanoma. The inconsistent results in the TCGA and literature studies in these tumors may be caused by sampling error and publication bias.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of LncRNA PVT1 and Its Potential Target Gene Network in Human Cancers: a Comprehensive Inquiry Based Upon 21 Cancer Types and 9972 Cases

Qin

Lin

et al. 2018

Cell Physiol Biochem

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Background/Aims: Whether the level of long noncoding RNA plasmacytoma variant translocation 1 gene (lncRNA PVT1) expression influences the clinical development and outcome of human cancers has not been thoroughly elucidated to date. Inconsistencies still exist regarding the associations between PVT1 and the clinicopathological features, including patient survival data. Additionally, the regulatory mechanism of PVT1 among human cancers remains unclear. Methods: we conducted a comprehensive inquiry to verify the implication of PVT1 expression in cancer patients by conducting a meta-analysis of 19 selected studies and The Cancer Genome Atlas (TCGA) database to examine the relationship between PVT1 expression and both the prognosis and clinicopathological features of cancer patients using STATA 12.0. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the potential mRNA target genes of PVT1 gathered from TANRIC and Multi Experiment Matrix (MEM) were performed. Results: The level of PVT1 expression in tumor tissues was higher than in paired non-cancer tissues and was significantly associated with a poorer prognosis in cancer patients. Additionally, overexpression of PVT1 was significantly correlated with histological differentiation, tumor (T) classification, lymph node (N) classification and TNM stages. Furthermore, a total of 462 validated target genes were identified, and the GO and KEGG analyses demonstrated that the validated targets of PVT1 were significantly enriched in several pathways, including the GnRH signaling pathway, the Cytokine-cytokine receptor interaction pathway, the Inflammatory mediator regulation of TRP channels pathway, and the Neuroactive ligand-receptor interaction pathway. Conclusion: PVT1 may serve as a potential biomarker associated with the progression and prognosis of human cancers.

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“…Chen J discovered that the expression of circPVT1 was upregulated in GC tissues and may promote cell proliferation by acting as a sponge for members of the miR-125 family. Besides, CircPVT1 could serve as an independent prognostic marker for overall survival and disease-free survival in patients with GC, which makes it a novel proliferative factor and prognostic marker in GC [36].…”

Section: Correlation Of Circrnas To Gastric Cancermentioning

confidence: 99%

Landscape of Circular RNAs in the Clinical Application of Digestive System Neoplasm

Zhou¹,

Fu²,

Hu³

et al. 2018

Chemotherapy

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It has been confirmed that noncoding RNAs (ncRNAs) play an important role in cellular development, differentiation, proliferation and apoptosis of various carcinomas. As a member of the ncRNAs family, circular RNAs (circRNAs) are getting new research hotspots because of their newly discovered and numerous potential functions such as acting as microRNA (miRNA) sponges and binding to RNA-binding proteins (RBPs) to modulate the gene transcription. Herein, we review the current understanding of the roles of circRNAs in the clinical application of digestive system neoplasm and provide a new insight into the potential implications in the diagnosis and targeted therapy of digestive system carcinomas.

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Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer

Cited by 612 publications

References 27 publications

Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers

Overexpression of LncRNA PVT1 Predicts Advanced Clinicopathological Features and Serves as an Unfavorable Risk Factor for Survival of Patients with Gastrointestinal Cancers

Prognostic Significance of LncRNA PVT1 and Its Potential Target Gene Network in Human Cancers: a Comprehensive Inquiry Based Upon 21 Cancer Types and 9972 Cases

Landscape of Circular RNAs in the Clinical Application of Digestive System Neoplasm

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