Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

Lai, Qun; Wang, Min; Hu, Chunmei; Tang, Yan; Li, Yarong; Hao, Shuhong

doi:10.3892/ol.2021.13078

Cited by 5 publications

(3 citation statements)

References 102 publications

(134 reference statements)

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“…Post recurrence in TNBC patients, MAPK overexpression correlated with poor survival (Eralp et al 2008 ; Bartholomeusz et al 2012 ). Activating MAPK/JNK and p38MAPK pathway causes damage to mitochondria, which is connected with disease progression and prognosis of many cancers (Lai et al 2021 ). p38 MAPK regulates cell fate by mediating cell survival or death depending on the type of stimulus and the specific cell type.…”

Section: Signaling Pathways That Circrnas Use To Regulate Breast Canc...mentioning

confidence: 99%

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Gopikrishnan

Ramanathan

et al. 2023

Funct Integr Genomics

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Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.

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Section: Signaling Pathways That Circrnas Use To Regulate Breast Canc...mentioning

confidence: 99%

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Gopikrishnan

Ramanathan

et al. 2023

Funct Integr Genomics

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“…Colorectal cancer. Colorectal cancer (CRC) is the fourth most deadly cancer in the world, largely due to its non-specific symptoms and late-stage diagnosis, resulting in a 5-year relative survival rate of 14% (54). However, the 5-year survival rate for localized CRC is much higher at 90% (55,56).…”

Section: Circ_nrip1 In Malignant Tumorsmentioning

confidence: 99%

Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)

Gào

Wang

et al. 2023

Oncol Lett

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Circular RNA (circRNA) is a class of endogenous non-coding RNA, a type of single-stranded covalently closed RNA molecule formed by alternative splicing of exons or introns. Previous studies have demonstrated that circRNA participates in modulating biological processes such as cell proliferation, differentiation and apoptosis, and plays key roles in tumor occurrence and development. CircRNA nuclear receptor interacting protein 1 (circ_NRIP1), a form of circRNA, is abnormally expressed in certain human tumor types. It is present at a higher abundance compared with cognate linear transcripts and can regulate malignant biological behaviors such as tumor proliferation, invasion and migration, revealing a currently unexplored frontier in cancer progression. The present review presents a pattern of circ_NRIP1 expression in various malignant tumor types and highlights its significance in cancer development, in addition to its potential as a disease indicator or future therapeutic agent. Contents 1. Introduction 2. Circ_NRIP1 in malignant tumors 3. Conclusion and future perspectives

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“…Because of the deficiency of 5′ and 3′ terminals in structures, circRNAs are more stable than linear RNAs ( Li et al, 2015 ). Studies have showed the important roles of aberrant circRNA-associated signaling in cancer pathogenesis and therapeutic response ( Lai et al, 2021 ; Chen et al, 2022 ). Because of their unique closed-loop form and structural stability, circRNAs have been serving as novel prognostic and therapeutic targets for human cancers ( Jiao et al, 2021 ; Lan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

Kang

Yan²,

Liu³

et al. 2023

Front. Pharmacol.

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Exosomes are nanoscale extracellular vesicles secreted by a variety of cells, affecting the physiological and pathological homeostasis. They carry various cargoes including proteins, lipids, DNA, and RNA and have emerged as critical mediators of intercellular communication. During cell–cell communication, they can internalize either by autologous or heterologous recipient cells, which activate different signaling pathways, facilitating malignant progression of cancer. Among different types of cargoes in exosomes, the endogenous non-coding RNAs, such as circular RNAs (or circRNAs), have gained tremendous attention for their high stability and concentration, playing promising functional roles in cancer chemotherapeutic response by regulating the targeted gene expression. In this review, we primarily described the emerging evidence demonstrating the important roles of circular RNAs derived from exosomes in the regulation of cancer-associated signaling pathways that were involved in cancer research and therapeutic interventions. Additionally, the relevant profiles of exosomal circRNAs and their biological implications have been discussed, which is under investigation for their potential effect on the control of cancer therapeutic resistance.

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Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

Cited by 5 publications

References 102 publications

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer

Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)

Unraveling the significance of exosomal circRNAs in cancer therapeutic resistance

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