Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases

Joaquim, Victor Hugo Antonio; Pereira, Noemy Pinto; Fernandes, Tiago; Oliveira, Edilamar Menezes de

doi:10.3390/ijms24032125

Cited by 11 publications

(4 citation statements)

References 118 publications

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“…The detected circRNAs were considered non-functional or splicing by-products; however, with the development of high-throughput sequencing and bioinformatics approaches, it was found that circRNAs are highly expressed in all eukaryotic cells and perform certain functions [ 35 ]. Recent studies have shown that circRNAs are critical regulators of cell physiology and various pathologies by modulating gene expression [ 29 , 36 , 37 , 38 , 39 ].…”

Section: Characteristics and Functions Of Circrnasmentioning

confidence: 99%

“…The use of circRNAs as therapeutic targets in CAD has been widely discussed [ 24 , 29 , 170 ]. An attractive therapy strategy is the creation and use of artificial circRNAs in the form of miRNA sponges [ 171 ].…”

Section: Circrnas Are Promising Biomarkers and Therapeutic Targets Fo...mentioning

confidence: 99%

“…circRNAs have broad post-transcriptional regulatory activity, acting as ceRNAs [ 21 , 26 ]. Acting as sponges for miRNAs [ 27 , 28 ], they are involved in the circRNA-miRNA–mRNA regulatory axes associated with the pathogenesis of cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, and CAD [ 29 , 30 , 31 ]. With their high resistance to endonucleases, circRNAs are promising diagnostic biomarkers and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNAs Variously Participate in Coronary Atherogenesis

Dergunova,

Vinogradina,

Filippenkov

et al. 2023

CIMB

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Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to the class of non-coding RNAs and arise as a result of non-canonical splicing of premature RNA, which results in the formation of closed single-stranded circRNA molecules that lack 5′-end caps and 3′-end poly(A) tails. circRNAs have broad post-transcriptional regulatory activity. Acting as a sponge for miRNAs, circRNAs compete with mRNAs for binding to miRNAs, acting as competing endogenous RNAs. Numerous circRNAs are involved in the circRNA–miRNA–mRNA regulatory axes associated with the pathogenesis of cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, and coronary artery disease. Recent studies have shown that сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, and circ_0003423 are involved in the pathogenesis of coronary artery disease (CAD) with an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, and circ_0050486 possess a proatherogenic effect. With their high resistance to endonucleases, circRNAs are promising diagnostic biomarkers and therapeutic targets. This review aims to provide updated information on the involvement of atherogenesis-related circRNAs in the pathogenesis of CAD. We also discuss the main modern approaches to detecting and studying circRNA–miRNA–mRNA interactions, as well as the prospects for using circRNAs as biomarkers and therapeutic targets for the treatment of cardiovascular diseases.

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Section: Characteristics and Functions Of Circrnasmentioning

confidence: 99%

Section: Circrnas Are Promising Biomarkers and Therapeutic Targets Fo...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circular RNAs Variously Participate in Coronary Atherogenesis

Dergunova,

Vinogradina,

Filippenkov

et al. 2023

CIMB

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“… 3 microRNAs are small RNAs that are mainly involved in the regulation of post-transcriptional translation of genes in mammals. 4 Studies have shown that microRNAs can attach to and silence genes involved in the atherogenesis pathway, thereby inhibiting the expression of proteins and cellular functions involved in regulating the stability of atherosclerotic plaques. It is thus possible that microRNAs may represent new targets for research to prevent and treat atherosclerotic diseases.…”

Section: Introductionmentioning

confidence: 99%

Potential new therapeutic targets: Association of microRNA with atherosclerotic plaque stability

Huang

2023

Int J Immunopathol Pharmacol

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Cardiovascular disease represents a major threat to human health with vascular atherosclerosis contributing significantly to its cause, particularly due to the ease of rupture of atherosclerotic plaques. The stability of atherosclerotic plaques is influenced by a variety of factors, including intraplaque neovascularization, the inflammatory response, smooth muscle cells and macrophages, and core lipid volumes. Thus, the investigation of factors affecting the stability of atherosclerotic plaques is of great significance for the development of new drugs for the treatment of atherosclerotic diseases. MicroRNAs are small single-stranded non-coding RNAs between 17 and 22 nucleotides in length. They are translated together with the untranslated region (UTR) of the target gene mRNA, where the completeness of base-pairing can influence the translation or degradation of the target genes. MicroRNAs can thus regulate gene expression at the post-transcriptional level and have been demonstrated to be extensively involved in the regulation of various factors affecting plaque stability. In this paper, we review microRNA development, factors affecting atherosclerotic plaque stability, and the relationship between microRNAs and plaque stability, with the aim of describing the mechanisms by which microRNAs affect gene and protein expression in relation to atherosclerosis progression (including plaque rupture) to suggest new therapeutic targets for atherosclerotic disease.

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