Circular RNAs expressed in chorionic villi are probably involved in the occurrence of recurrent spontaneous abortion

Qian, Yanyan; Wang, Xin; Ruan, Hongjie; Cheng, Rui; Mao, Pengyuan; Cheng, Qi; Jia, Ruizhe

doi:10.1016/j.biopha.2017.01.172

Cited by 15 publications

(16 citation statements)

References 20 publications

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“…Benefiting from the advances of bioinformatics tools, microarray, and RNA-sequencing techniques, the role of circRNAs in the regulation of gene expression has been profoundly recognized [63]. circRNA expression profiles are examined in pregnancy complications such as gestational diabetes [64] and recurrent spontaneous abortions [65]. circRNAs have also been proved to act as important contributors in ovarian and cervical cancer [66–68].…”

Section: Discussionmentioning

confidence: 99%

Role of Circular RNAs in Preeclampsia

Jia

2019

Disease Markers

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Circular RNAs (circRNAs) are noncoding RNAs characterized by circular covalently closed structures, which are generated by back-splicing. circRNA is more stable and conserved than linear RNA and exists in various organisms. Preeclampsia (PE), a common hypertensive disorder of pregnancy, has a profound impact on maternal and neonatal mortality and morbidity. Recent studies demonstrated that circRNAs were differentially expressed in PE maternal-fetal interface compared with those in the control and might mediate pathological processes in pregnancy complications. However, the mechanisms of action of circRNAs in PE are still unclear. Here, we provide a comprehensive review on the current state of knowledge on circRNAs associated with PE. We summarize the known expression profiles of circRNAs and discuss their potential application as biomarkers of PE. The possible mechanisms underlying circRNA dysregulation in the etiology of PE are also explored.

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Section: Discussionmentioning

confidence: 99%

Role of Circular RNAs in Preeclampsia

Jia

2019

Disease Markers

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“…This condition affects approximately 1%–2% women (European Society of Human Reproduction and Embryology, 2017). Using a circRNA microarray, Qian et al (2017) investigated the expression of circRNAs in three pairs of chorionic villus from patients with recurrent miscarriage versus controls. They found 335 upregulated and 259 downregulated circRNAs.…”

Section: Circrnas In Female Reproduction Diseasementioning

confidence: 99%

Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases

Gao

Wang

Pan

et al. 2021

Journal Cellular Physiology

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Circular RNAs (circRNAs) are endogenous noncoding RNAs with unique cyclic structures. Although they were previously considered as nonfunctional transcription byproducts, numerous studies have demonstrated that circRNAs regulate gene transcription and expression via different mechanisms. Reproductive health influences the quality of life and affects offspring propagation in women. CircRNAs have been found to modify pregnancy‐related diseases, gynecologic cancers, polycystic ovary syndrome, aging, gamete, and embryo development. It's promising for circRNAs to be the novel diagnostic and therapeutic targets for multiple reproductive diseases. With the widespread application of assisted reproduction technology (ART), it has been revealed that circRNA identification contributes to estimating the quality of gametes and embryos, reflecting the success rate of ART. CRISPR‐Cas9 gene editing technology has enabled the discovery of new roles of circRNAs. So far, the roles of circRNAs in the reproductive system remain poorly defined. In this review, we describe the classification and functions of circRNAs in embryogenesis and the female reproductive system diseases, revealing potential roles of circRNAs physiologically and pathologically. In so‐doing, we provide ideas for developing circRNA‐based therapeutic treatment and clinical application of various female reproductive system diseases.

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“…A circRNA microarray analysis identified aberrantly expressed circRNAs in the villi of patients with URSA. This may shed light on the role of circRNAs in the onset of URSA [35]. The circRNA microarray revealed miRNA-binding sites on many circRNAs.…”

Section: Ncrna Expression Profiling In Ursamentioning

confidence: 99%

“…The circRNA microarray revealed miRNA-binding sites on many circRNAs. Downregulation of the miRNAs miR-520f [27] and miR-181d [28], which have relevant binding sites on upregulated circRNAs, in URSA dNK cells may contribute to the inhibition of adhesion and cell proliferation [35]. However, the roles of circular RNA and competing endogenous RNA networks remain to be investigated.…”

Section: Ncrna Expression Profiling In Ursamentioning

confidence: 99%

Noncoding RNAs in Unexplained Recurrent Spontaneous Abortions and Their Diagnostic Potential

Jia

2019

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Unexplained recurrent spontaneous abortion (URSA) is defined as the loss of two or more consecutive pregnancies before the 20th week of gestation with normal findings on routine screening tests. Our understanding of the cellular and molecular pathogenesis of URSA is still far from complete. Noncoding RNAs (ncRNAs) play a pivotal role in transcription and expression. The functions of ncRNAs may also improve understanding of URSA pathogenesis. Because of their stability in the circulatory system and at the maternal-fetal interface, it may be possible to use ncRNAs as biomarkers for certain disease states. Here, we provide a narrative review of the current state of knowledge about ncRNAs associated with URSA. The possibility of developing a diagnostic tool using ncRNAs is discussed. The underlying mechanisms of how ncRNAs may lead to the onset of URSA are explored in this review.

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Circular RNAs expressed in chorionic villi are probably involved in the occurrence of recurrent spontaneous abortion

Cited by 15 publications

References 20 publications

Role of Circular RNAs in Preeclampsia

Role of Circular RNAs in Preeclampsia

Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy‐related diseases

Noncoding RNAs in Unexplained Recurrent Spontaneous Abortions and Their Diagnostic Potential

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