Circular RNAs in inflammatory bowel disease

Abstract

Inflammatory bowel disease (IBD) is a term encompassing a few chronic inflammatory disorders that leads to damage of the intestinal tract. Although much progress has been made in understanding the pathology of IBD, the precise pathogenesis is not completely understood. Circular RNAs (circRNAs) are single-stranded, covalently closed, endogenous molecules in eukaryotes with a variety of biological functions. CircRNAs have been shown to have regulatory effects in many diseases, such as cancer, cardiovascular disease, and neurological disorders. CircRNAs have also been found to play important roles in IBD, and although they are not sufficiently investigated in the context of IBD, a few circRNAs have been identified as potential biomarkers for the diagnosis and prognosis of IBD and as potential therapeutic targets for IBD. Herein, we survey recent progress in understanding the functions and roles of circRNAs in IBD and discuss their potential clinical applications.

Non-coding RNAs: targets for Chinese herbal medicine in treating myocardial fibrosis

“…For example, circFndc3b enhances the expression and signal transduction of vascular endothelial growth factor-A (VEGF-A) by interacting with RBP fused in sarcoma (FUS) ( Garikipati et al, 2019 ). What’s more, circRNA can also bind to the promoter region and enhance the transcription of its parent gene by interacting with U1 small ribonucleoprotein particles and RNA polymerase II ( Lun et al, 2023 ).…”