CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis

Fu, Lanfang; Zhang, Juyun; Zhu, Lin; Li, Yang; Qin, Guijun

doi:10.1080/21655979.2021.2024688

Cited by 25 publications

(15 citation statements)

References 51 publications

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“…Flow cytometry was used for detecting cell apoptosis [ 19 ]. Apoptotic cells were examined after staining by Annexin V-fluorescein isothiocyanate (Annexin V-FITC) and Propidium Iodide (PI) through Annexin V-FITC Apoptosis Detection Kit (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p

Wahafu

Tuo

et al. 2022

Bioengineered

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Circular RNAs (circRNAs) can regulate the progression of osteoarthritis (OA) via serving as competing endogenous RNAs (ceRNAs). This work was performed for functional research of circ_0005526 in Interleukin-1β (IL-1β)-induced OA injury. Circ_0005526, microRNA-142-5p (miR-142-5p) or transcription factor 4 (TCF4) expression was measured via reverse transcription-quantitative polymerase chain reaction assay. Cell analysis was performed by Cell Counting Kit-8 assay for cell viability, EdU assay for cell proliferation and flow cytometry for cell apoptosis. The protein level detection was conducted using western blot. Target analysis was carried out via dual-luciferase reporter assay and RNA pull-down assay. Circ_0005526 was upregulated in OA cartilage tissues and IL-1β-exposed chondrocyte cells. IL-1β inhibited cell viability and proliferation but enhanced cell apoptosis and inflammation, then these damages were attenuated after downregulation of circ_0005526. Circ_0005526 interacted with miR-142-5p, and circ_0005526 knockdown suppressed IL-1β-induced OA progression through upregulating miR-142-5p. TCF4 was regulated by circ_0005526 via targeting miR-142-5p. The function of circ_0005526 was also achieved by upregulation of TCF4. These results unraveled that circ_0005526 promoted IL-1β-induced chondrocyte injury in OA via suppressing miR-142-5p binding to TCF4.

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Section: Methodsmentioning

confidence: 99%

Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p

Wahafu

Tuo

et al. 2022

Bioengineered

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“…Cell apoptosis was assessed using flow cytometry as previously described [ 20 ]. Annexin V Apoptosis Kit (BD Biosciences, San Diego, CA, USA) was employed to examine apoptotic cells.…”

Section: Methodsmentioning

confidence: 99%

Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)

Zhang

Jiao

et al. 2022

Bioengineered

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“…Hsa_circ_0076631 is increased in HG-treated cardiomyocytes and in the serum of patients with DM, and circ_0071269 is upregulated in HG-treated H9c2 cells. Both these circRNAs promote the inflammatory response and pyroptosis via the hsa_circ_0076631−miR-214-3p−caspase-1 axis ( 114 ) and microRNA-145−gasdermin A axis ( 115 ), respectively. Knockdown of these circRNAs protects against diabetic cardiomyopathy injury, implying an accurate therapy for DC.…”

Section: Role Of Circrnas In Dm-associated Complicationsmentioning

confidence: 99%

Circular RNAs in diabetes mellitus and its complications

et al. 2022

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Diabetes mellitus (DM) is an endocrine disorder characterized by a relative or absolute lack of insulin due to the dysfunction or destruction of β-cells. DM is one of the fastest growing challenges to global health in the 21st century and places a tremendous burden on affected individuals and their families and countries. Although insulin and antidiabetic drugs have been used to treat DM, a radical cure for the disease is unavailable. The pathogenesis of DM remains unclear. Emerging roles of circular RNAs (circRNAs) in DM have become a subject of global research. CircRNAs have been verified to participate in the onset and progression of DM, implying their potential roles as novel biomarkers and treatment tools. In the present review, we briefly introduce the characteristics of circRNAs. Next, we focus on specific roles of circRNAs in type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus and diabetes-associated complications.

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CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis

Cited by 25 publications

References 51 publications

Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p

Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p

Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)

Circular RNAs in diabetes mellitus and its complications

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