Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis

Kawashima, Junichi; Ohno, Shino; Sakurada, Tomoya; Takabayashi, Hidehiko; Kudo, M.; Ro, Shoki; Kato, Shingo; Yakabi, Koji

doi:10.1007/s00535-009-0120-0

Cited by 52 publications

(32 citation statements)

References 37 publications

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“…Indeed, our study demonstrated that PG I/II ratio correlated positively with systolic blood pressure, serum triglyceride and uric acid concentrations in patients without Hp infection. Plasma ghrelin levels have been reported to be correlated positively with serum PG I levels and PG I/II ratio [8,9], and plasma ghrelin levels decrease in accordance with the extent of atrophic changes in gastric mucosa irrespective of Hp infection [10]. In addition to its ability to stimulate growth hormone secretion and gastric motility, ghrelin stimulates appetite and induces a positive energy balance leading to body weight gain [11,12].…”

Section: Resultsmentioning

confidence: 98%

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Senmaru

Fukui

Kuroda³

et al. 2013

Endocr J

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Section: Resultsmentioning

confidence: 98%

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Senmaru

Fukui

Kuroda³

et al. 2013

Endocr J

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“…However, the performance of gastrin-17 test alone is not enough to detect atrophy and the test is mostly used with combination of a test-pannel including PGA and PGC [30,31]. Total ghrelin, a recently reported serologic marker, has been previously shown to be related to histological atrophy [32–35]. In an earlier study of 220 subjects, including patients both with and without atrophic gastritis, plasma ghrelin concentrations decreased along with the extent of atrophic changes in the gastric mucosa, irrespective of H .…”

Section: Discussionmentioning

confidence: 99%

“…In an earlier study of 220 subjects, including patients both with and without atrophic gastritis, plasma ghrelin concentrations decreased along with the extent of atrophic changes in the gastric mucosa, irrespective of H . pylori infection [32]. In another study that assessed correlations between ghrelin levels and the histologic severity and topographical extent of chronic gastritis, ghrelin levels progressively decreased from a normal state, to antrum-predominant gastritis, to pan-gastritis, and finally to corpus-dominant gastritis [33].…”

Section: Discussionmentioning

confidence: 99%

Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma

Cho

Bae

et al. 2017

PLoS ONE

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BackgroundIn patients with adenoma, assessing premalignant changes in the surrounding mucosa is important for surveillance. This study evaluated atrophic and metaplastic progression in the background mucosa of adenoma or early gastric cancer (EGC) cases.MethodsAmong 146 consecutive patients who underwent endoscopic resection for intestinal-type gastric neoplasia, the adenoma group included 56 patients with low-grade dysplasia and the ECG group included 90 patients with high-grade dysplasia or invasive carcinoma. For histology, 3 paired biopsies were obtained from the antrum, corpus lesser curvature (CLC), and corpus greater curvature (CGC). Serological atrophy was determined based on pepsinogen A (PGA), progastricsin (PGC), gastrin-17, and total ghrelin levels. Topographic progression of atrophy and/or metaplasia was staged using the operative link on gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) systems.ResultsRates of moderate-to-marked histological atrophy/metaplasia in patients with adenoma were 52.7%/78.2% at the antrum (vs. 58.8%/76.4% in EGC group), 63.5%/75.0% at the CLC (vs. 60.2%/69.7% in EGC group), and 10.9%/17.9% at the CGC (vs. 5.6%/7.8% in EGC group). Serological atrophy indicated by PGA and PGC occurred in 23.2% and 15.6% of cases in the adenoma and ECG groups, respectively (p = 0.25). Mean serum gastrin-17 concentrations of the adenoma group and EGC group were 10.4 and 9.0 pmol/L, respectively (p = 0.54). Mean serum total ghrelin levels were 216.6 and 209.5 pg/mL, respectively (p = 0.71). Additionally, between group rates of stage III–IV OLGA and OLGIM were similar (25.9% vs. 25.0%, p = 0.90; 41.8% vs. 44.9%, p = 0.71, respectively).ConclusionsAtrophic and metaplastic progression is extensive and severe in gastric adenoma patients. A surveillance strategy for metachronous tumors should be applied similarly for patients with adenoma or EGC.

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“…This however was not observed in a longitudinal communitybased study which looked at serological markers of H. pylori infection carried out in Europe [68]. The proposed association between H. pylori eradication and obesity is thought to be mediated through ghrelin, a hormone which regulates appetite and which is secreted from the ghrelin-producing (GR) cells which are diminished in gastric mucosal atrophy caused by H. pylori infection [69]. Again though, a large, population-based US cohort failed to show an association between H. pylori status and BMI [70].…”

Section: Extra-gastric Manifestationsmentioning

confidence: 97%

Helicobacter pyloriinfection in Europe: current perspectives

OʼConnor

O’Moráin

2013

Expert Review of Gastroenterology & Hepatology

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There is a commonly held perception that Helicobacter pylori related diseases are declining, however these are still associated with a high risk of morbidity and mortality. In recent years worrying themes have emerged such as increasing levels of antibiotic resistance and falling cure rates which illustrate there is no room for complacency with respect to H. pylori. In addition there are many significant issues which have not been elucidated regarding the role played by H. pylori in very serious pathologies such as gastric and esophageal cancer and other more benign disorders common in the developed world such as gastroesophageal reflux disease, functional dyspepsia and perhaps obesity which carry a significant impact both economically and as regards to symptoms. Future guidelines aimed at European practitioners and patients will need to address the questions raised by these issues as well as the more familiar areas such as constituents and duration of therapy.

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Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis

Cited by 52 publications

References 37 publications

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes

Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma

Helicobacter pyloriinfection in Europe: current perspectives

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